Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription

Abstract

SummarySmad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription

Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c- myc expression in the absence of TGF-β signaling

“…A previous study from the Alk3QD (constitutively activated BMP receptor) transgenic mouse showed that BMP signaling can activate the c-myc promoter through a Smad1-TCF-␤-catenin complex in mouse renal tissue (25). This raised a question that BMP signaling might be responsible for the positive function of Smad4 on TBE1; that is, the Smad1-Smad4 complex activated by BMP signaling is binding the TBE1 region.…”

Diversity of LEF/TCF action in development and disease

“…LEF-1 also cooperates with SMADs bound to neighboring elements to mediate Wnt and TGF-b/BMP regulation of gene targets (Labbe et al, 2000;Nishita et al, 2000;Hussein et al, 2003). However, whether these interactions are strictly LEF-1-specific is unlikely since interactions between SMAD1 and TCF-4 have been defined within the mouse MYC promoter (Hu and Rosenblum, 2005) and in Drosophila these two pathways converge on neighboring elements (Riese et al, 1997). Another group of factors that engage in cooperative interactions are members of the homeodomain family.…”

Finding partners: How BMPs select their targets

“…Smad1 protein has also been found to physically interact with HoxC8, Nkx3-2, YY1, ␤-catenin/Lef1 complex, and Gata factors 4, 5, and 6 (Shi et al, 1999;Kim and Lassar, 2003;Benchabane and Wrana, 2003;Brown et al, 2004;Lee et al, 2004;Hu and Rosenblum, 2005).…”