Small animal models of localized heart irradiation

Boerma, Marjan; Sridharan, Vijayalakshmi; Krager, Kimberly J.; Pawar, Snehalata A.

doi:10.1016/bs.mcb.2021.12.016

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Different types of radiation approaches are being applied in pre-clinical settings like partial heart irradiation, whole thorax, and whole heart radiation with radiation delivery methods like conformal systems and single beam with lead shielding [124]. Recent studies in rodent models have confirmed that adverse cardiac remodeling as delayed effects of acute radiation exposure (DEARE) after total body irradiation (TBI) or partial body irradiation (PBI) can indeed be reproduced in animal models [125][126][127][128][129]. Inflammation is thought to play an important role in the development of RIHD [7].…”

Section: Role Of Tlr4 In Rihd In Rodent Modelsmentioning

confidence: 99%

TLR4—A Pertinent Player in Radiation-Induced Heart Disease?

Gawali

Sridharan

Krager

et al. 2023

Genes

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The heart is one of the organs that is sensitive to developing delayed adverse effects of ionizing radiation (IR) exposure. Radiation-induced heart disease (RIHD) occurs in cancer patients and cancer survivors, as a side effect of radiation therapy of the chest, with manifestation several years post-radiotherapy. Moreover, the continued threat of nuclear bombs or terrorist attacks puts deployed military service members at risk of exposure to total or partial body irradiation. Individuals who survive acute injury from IR will experience delayed adverse effects that include fibrosis and chronic dysfunction of organ systems such as the heart within months to years after radiation exposure. Toll-like receptor 4 (TLR4) is an innate immune receptor that is implicated in several cardiovascular diseases. Studies in preclinical models have established the role of TLR4 as a driver of inflammation and associated cardiac fibrosis and dysfunction using transgenic models. This review explores the relevance of the TLR4 signaling pathway in radiation-induced inflammation and oxidative stress in acute as well as late effects on the heart tissue and the potential for the development of TLR4 inhibitors as a therapeutic target to treat or alleviate RIHD.

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Section: Role Of Tlr4 In Rihd In Rodent Modelsmentioning

confidence: 99%

TLR4—A Pertinent Player in Radiation-Induced Heart Disease?

Gawali

Sridharan

Krager

et al. 2023

Genes

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“…In the continuous development and innovation of medicine, animal research plays an indispensable role [ 1 ]. Specifically, studies on life sciences, disease mechanisms, and drug efficacy as well as side effects require animal models for preclinical experiments [ 2 , 3 , 4 , 5 ]. Animal magnetic resonance imaging (MRI) is a non-invasive in vivo imaging technology with a high spatial and temporal resolution, enabling real-time and repetitive imaging of rodents such as mice in medical experiments, thereby allowing us to obtain a detailed observation of disease changes and trends in animal models [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Application Value of a Novel Micro-Coil in High-Resolution Imaging of Experimental Mice Based on 3.0 T Clinical MR

Qiu,

Liu,

2024

Tomography

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The clinical magnetic resonance scanner (field strength ≤ 3.0 T) has limited efficacy in the high-resolution imaging of experimental mice. This study introduces a novel magnetic resonance micro-coil designed to enhance the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), thereby improving high-resolution imaging in experimental mice using clinical magnetic resonance scanners. Initially, a phantom was utilized to determine the maximum spatial resolution achievable by the novel micro-coil. Subsequently, 12 C57BL/6JGpt mice were included in this study, and the novel micro-coil was employed for their scanning. A clinical flexible coil was selected for comparative analysis. The scanning methodologies for both coils were consistent. The imaging clarity, noise, and artifacts produced by the two coils on mouse tissues and organs were subjectively evaluated, while the SNR and CNR of the brain, spinal cord, and liver were objectively measured. Differences in the images produced by the two coils were compared. The results indicated that the maximum spatial resolution of the novel micro-coil was 0.2 mm. Furthermore, the subjective evaluation of the images obtained using the novel micro-coil was superior to that of the flexible coil (p < 0.05). The SNR and CNR measurements for the brain, spinal cord, and liver using the novel micro-coil were significantly higher than those obtained with the flexible coil (p < 0.001). Our study suggests that the novel micro-coil is highly effective in enhancing the image quality of clinical magnetic resonance scanners in experimental mice.

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