Small-Animal Research Imaging Devices

Fine, Eugene J.; Herbst, Lawrence H.; Jelicks, Linda A.; Koba, Wade; Theele, Daniel P.

doi:10.1053/j.semnuclmed.2013.08.006

Cited by 15 publications

(10 citation statements)

References 25 publications

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“…The small-animal CT produces 3- dimensional (3D) x-ray images were based on the information of tissue densities, which were able to reconstruct a high-definition 3D images of animals with a resolution up to 100 μm. [34] Therefore, CT imaging was able to provide a precise monitoring of the suture effectiveness and i-NG’s structural integrity inside the mouse body. At the 4th, 12th, and 24th week of postimplantation, the same ICR mice implanted with NGs were scanned by CT.…”

Section: Resultsmentioning

confidence: 99%

Study of long-term biocompatibility and bio-safety of implantable nanogenerators

Liu

et al. 2018

Nano Energy

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Implantable nanogenerator (i-NG) has shown great promises for enabling self-powered implantable medical devices (IMDs). One essential requirement for practical i-NG applications is its long-term bio-compatibility and bio-safety. This paper presents a systematic study of polydimethylsiloxane (PDMS) and PDMS/Parylene-C packaged Polyvinylidene fluoride (PVDF) NGs implanted inside female ICR (Institute of Cancer Research) mice for up to six months. The PVDF NG had a stable in vitro output of 0.3 V when bended for 7200 cycles and an in vivo output of 0.1V under stretching. Multiple advanced imaging techniques, including computed tomography (CT), ultrasound, and photoacoustic were used to characterize the embedded i-NGs The i-NGs kept excellent adhesion to the adjacent muscle surface, and exhibited stable electrical output during the entire examine period. No signs of toxicity or incompatibility were observed from the surrounding tissues, as well as from the whole body functions by pathological analyses and blood and serum test. The PDMS package was also able to effectively insulate the i-NG in biological environment with negligible stray currents at a pA scale. This series of and study confirmed the biological feasibility of using i-NG for biomechanical energy harvesting.

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Section: Resultsmentioning

confidence: 99%

Study of long-term biocompatibility and bio-safety of implantable nanogenerators

Liu

et al. 2018

Nano Energy

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“…By contrast, PET and SPECT imaging modalities, which are highly sensitive to administered radiolabelled molecules, allow the identification of metabolic and physiological activity of the tissues (Koba et al, 2013). Among the novel promising tools in constant development, molecular ultrasound, high field MRI as well as photoacoustic and optical imaging are playing a significant role (Fine et al, 2014).…”

Section: Advances In Imaging Systemsmentioning

confidence: 99%

Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects

D’Elia

Schiavi

Soluri

et al. 2020

Front. Behav. Neurosci.

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Molecular imaging, which allows the real-time visualization, characterization and measurement of biological processes, is becoming increasingly used in neuroscience research. Scintigraphy techniques such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) provide qualitative and quantitative measurement of brain activity in both physiological and pathological states. Laboratory animals, and rodents in particular, are essential in neuroscience research, providing plenty of models of brain disorders. The development of innovative high-resolution small animal imaging systems together with their radiotracers pave the way to the study of brain functioning and neurotransmitter release during behavioral tasks in rodents. The assessment of local changes in the release of neurotransmitters associated with the performance of a given behavioral task is a turning point for the development of new potential drugs for psychiatric and neurological disorders. This review addresses the role of SPECT and PET small animal imaging systems for a better understanding of brain functioning in health and disease states. Brain imaging in rodent models faces a series of challenges since it acts within the boundaries of current imaging in terms of sensitivity and spatial resolution. Several topics are discussed, including technical considerations regarding the strengths and weaknesses of both technologies. Moreover, the application of some of the radioligands developed for small animal nuclear imaging studies is discussed. Then, we examine the changes in metabolic and neurotransmitter activity in various brain areas during task-induced neural activation with special regard to the imaging of opioid, dopaminergic and cannabinoid receptors. Finally, we discuss the current status providing future perspectives on the most innovative imaging techniques in small laboratory animals. The challenges and solutions discussed here might be useful to better understand brain functioning allowing the translation of preclinical results into clinical applications.

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“…Dr. Rizi’s group, for example, used HP MRI to determine the apparent diffusion coefficient in rat models of emphysema as a non-invasive measure of airspace enlargement, 37 as well as to measure lactate-to-pyruvate ratios in a rat model of acute lung injury. 38 Micro-PET, with a resolution of 1–1.4 mm, 26 , 39 has been used in mice to detect lung metastases 26 and to measure glucose uptake in a model of acute lung injury, 40 to name just a few examples. These techniques require specialized facilities to generate tracers and sophisticated analysis by experts in the field.…”

Section: Small Animal Lung Imagingmentioning

confidence: 99%

Novel imaging approaches for small animal models of lung disease (2017 Grover Conference series)

Pinar

Jones

2018

Pulm. circ.

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Imaging in small animal models of lung disease is challenging, as existing technologies are limited either by resolution or by the terminal nature of the imaging approach. Here, we describe the current state of small animal lung imaging, the technological advances of laboratory-sourced phase contrast X-ray imaging, and the application of this novel technology and its attendant image analysis techniques to the in vivo imaging of the large airways and pulmonary vasculature in murine models of lung health and disease.

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Small-Animal Research Imaging Devices

Cited by 15 publications

References 25 publications

Study of long-term biocompatibility and bio-safety of implantable nanogenerators

Study of long-term biocompatibility and bio-safety of implantable nanogenerators

Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects

Novel imaging approaches for small animal models of lung disease (2017 Grover Conference series)

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