2019
DOI: 10.1039/c9md00329k
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Small antibacterial molecules highly active against drug-resistant Staphylococcus aureus

Abstract: The rapid growth of antibiotic resistance in Staphylococcus aureus coupled with their biofilm forming ability has made the infections difficult to treat with conventional antibiotics.

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Cited by 26 publications
(27 citation statements)
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“…The stained bacterial cells were observed with an inverted fluorescence microscope (Olympus, Waltham, MA, United States) equipped with a camera under a 40× objective and 10× optical lens using a NIS-Elements D software. In this technique both live and dead cells are stained fluorescent green by SYTO 9 and dead or membrane compromised cells are re-stained red by propidium iodide, masking the initial green stain on the dead cells (Boulos et al, 1999;Dey et al, 2019).…”
Section: Antimicrobial Testsmentioning
confidence: 99%
“…The stained bacterial cells were observed with an inverted fluorescence microscope (Olympus, Waltham, MA, United States) equipped with a camera under a 40× objective and 10× optical lens using a NIS-Elements D software. In this technique both live and dead cells are stained fluorescent green by SYTO 9 and dead or membrane compromised cells are re-stained red by propidium iodide, masking the initial green stain on the dead cells (Boulos et al, 1999;Dey et al, 2019).…”
Section: Antimicrobial Testsmentioning
confidence: 99%
“…After incubation at 37°C for 1 h, the samples were centrifuged and measured at A 570nm ( Tan et al, 2020 ). The results were expressed as HC 50 (concentration of 50% hemolysis of red blood cells) ( Dey et al, 2019 ). The hemolysis rate was calculated as follows:…”
Section: Methodsmentioning
confidence: 99%
“…Antimicrobial activity in physiological fluids was measured following previously reported protocol with minor modifications. , Briefly, co-β-peptide solution (1 mg/mL in PBS) was mixed with mouse blood plasma or liver homogenate at a 1:1 ratio and preincubated for 12 or 24 h at 37 °C. Subsequently, the MIC values of each mixture were measured following the above-described protocol.…”
Section: Methodsmentioning
confidence: 99%