Small biomolecule immunosensing with plasmonic optical fiber grating sensor

Ribaut, Clotilde; Voisin, Valérie; Malachovská, Viera; Dubois, Valentin; Mégret, Patrice; Wattiez, Ruddy; Caucheteur, Christophe

doi:10.1016/j.bios.2015.09.019

Cited by 101 publications

(52 citation statements)

References 35 publications

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“…Fibre SPR refractometers with sensitivities of ∼500 nm RIU −1 in aqueous solutions have been demonstrated17. Biochemical sensors based on the antibody/antigen affinity have also been reported for proteins and cell immunosensing1819202122. They present limits of detection and sensitivities that compete with the most sophisticated plasmonic-based sensing solutions2324.…”

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confidence: 99%

Ultrasensitive plasmonic sensing in air using optical fibre spectral combs

et al. 2016

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Surface plasmon polaritons (SPP) can be excited on metal-coated optical fibres, enabling the accurate monitoring of refractive index changes. Configurations reported so far mainly operate in liquids but not in air because of a mismatch between permittivities of guided light modes and the surrounding medium. Here we demonstrate a plasmonic optical fibre platform that overcomes this limitation. The underpinning of our work is a grating architecture—a gold-coated highly tilted Bragg grating—that excites a spectral comb of narrowband-cladding modes with effective indices near 1.0 and below. Using conventional spectral interrogation, we measure shifts of the SPP-matched resonances in response to static atmospheric pressure changes. A dynamic experiment conducted using a laser lined-up with an SPP-matched resonance demonstrates the ability to detect an acoustic wave with a resolution of 10−8 refractive index unit (RIU). We believe that this configuration opens research directions for highly sensitive plasmonic sensing in gas.

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Ultrasensitive plasmonic sensing in air using optical fibre spectral combs

et al. 2016

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“…To obtain high measurement accuracy, it is necessary to provide an accurate determination of the plasmon resonance wavelength and its variation with small changes in the refractive index. In a number of publications, observing the spectral position of plasmon resonance by measuring the intensity of one of the spectral peaks close to the spectral constriction is proposed . However, in real conditions, such an analysis gives a high probability of error, low reproducibility, and the inability to perform measurements across a wide range of refractive indices.…”

Section: Methodsmentioning

confidence: 99%

Ultrastable Combined Planar‐Fiber Plasmon Sensor

Tomyshev

Tazhetdinova

Manuilovich

et al. 2018

Physica Status Solidi (a)

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A new design for a hybrid fiber‐planar refractive index sensor based on the surface plasmon resonance effect is presented. The key element of the design is a thin layer of gold covering a tilted fiber Bragg grating. In the study, a specially developed microfluidic chip is used to perform measurements directly in the flow of the investigated liquid. Rigidly mounting the sensor to the base of the fluid chip is proposed. The presented experimental data demonstrate the high stability of the sensor readings and the low noise level during measurements in a liquid flow. The proposed construction is a promising decision for application in compact immunoassay systems based on microfluidic technologies.

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“…A sputter coater was used for this purpose. The coated gratings were then cured at 200 °C during 6 hours for improved gold adhesion23.…”

Section: Methodsmentioning

confidence: 99%

Negative axial strain sensitivity in gold-coated eccentric fiber Bragg gratings

Chah

Kinet

Caucheteur

2016

Sci Rep

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New dual temperature and strain sensor has been designed using eccentric second-order fiber Bragg gratings produced in standard single-mode optical fiber by point-by-point direct writing technique with tight focusing of 800 nm femtosecond laser pulses. With thin gold coating at the grating location, we experimentally show that such gratings exhibit a transmitted amplitude spectrum composed by the Bragg and cladding modes resonances that extend in a wide spectral range exceeding one octave. An overlapping of the first order and second order spectrum is then observed. High-order cladding modes belonging to the first order Bragg resonance coupling are close to the second order Bragg resonance, they show a negative axial strain sensitivity (−0.55 pm/με) compared to the Bragg resonance (1.20 pm/με) and the same temperature sensitivity (10.6 pm/°C). With this well conditioned system, temperature and strain can be determined independently with high sensitivity, in a wavelength range limited to a few nanometers.

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Small biomolecule immunosensing with plasmonic optical fiber grating sensor

Cited by 101 publications

References 35 publications

Ultrasensitive plasmonic sensing in air using optical fibre spectral combs

Ultrasensitive plasmonic sensing in air using optical fibre spectral combs

Ultrastable Combined Planar‐Fiber Plasmon Sensor

Negative axial strain sensitivity in gold-coated eccentric fiber Bragg gratings

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