Small but mighty: the rise of microprotein biology in neuroscience
Erin E. Duffy,
Elena G. Assad,
Brian T. Kalish
et al.
Abstract:The mammalian central nervous system coordinates a network of signaling pathways and cellular interactions, which enable a myriad of complex cognitive and physiological functions. While traditional efforts to understand the molecular basis of brain function have focused on well-characterized proteins, recent advances in high-throughput translatome profiling have revealed a staggering number of proteins translated from non-canonical open reading frames (ncORFs) such as 5′ and 3′ untranslated regions of annotate… Show more
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