Small Cell and Other Rare Histologic Types of Cervical Cancer

Marchocki, Zibi; Swift, Brenna; Covens, Allan

doi:10.1007/s11912-022-01316-x

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…Understanding the molecular classifications of RCs could provide directions for successful targeted therapies. The common treatment options for male and female RCs are chemotherapy, immunotherapy, and radiotherapy [28][29][30][31]. PCa is classified into several subtypes with different clinicopathological features based on eight molecular classifications: tomlins, the cancer genome atlas (TCGA), prostate cancer 14-pathway (PCS), 50-gene signature (PAM50), bone-metastatic, epithelial, immune, and multi-omics [28].…”

Section: Introductionmentioning

confidence: 99%

“…SCCC and gastric-type adenocarcinoma are characterized by high genetic alterations, including mutations in TP53, Kirsten rat sarcoma viral oncogene homologue (KRAS), phosphatase and tensin homologue (PTEN), AT-rich interaction domain 1A (ARID1A), and p110alpha catalytic subunit of PI3K (PIK3CA). Immune checkpoint inhibitors such as poly(ADP-ribose) polymerase (PARP) inhibitors have shown the potential to inhibit PARP expression in SCCC cells [31].…”

Section: Introductionmentioning

confidence: 99%

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A Review with a Focus on Vaccinium-Berries-Derived Bioactive Compounds for the Treatment of Reproductive Cancers

Alsharairi

2024

Plants

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Cancers of the reproductive organs, including prostate, bladder, ovarian, and cervical cancers, are considered the most common causes of death in both sexes worldwide. The genus Vaccinium L. (Ericaceae) comprises fleshy berry crop species, including cranberries, blueberries, lingonberries, bilberries, and bog bilberries, and are widely distributed in many countries. Flavonols, anthocyanins (ACNs), proanthocyanidins (PACs), and phenolic acids are the most bioactive compounds naturally found in Vaccinium berries and have been extensively used as anticancer agents. However, it remains uncertain whether Vaccinium bioactives have a therapeutic role in reproductive cancers (RCs), and how these bioactives could be effective in modulating RC-related signalling pathways/molecular genes. Therefore, this article aims to review existing evidence in the PubMed/MEDLINE database on Vaccinium berries’ major bioactive compounds in RC treatment and unravel the mechanisms underlying this process.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review with a Focus on Vaccinium-Berries-Derived Bioactive Compounds for the Treatment of Reproductive Cancers

Alsharairi

2024

Plants

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“…Small-cell neuroendocrine carcinoma of the cervix (SCNCC) is a rare pathological type of cervix neoplasm with highly aggressive biological behaviors and poorer prognosis than the most common counterpart with squamous carcinoma [1,2]. Several different names were used in the past and now it is considered a high-grade malignancy classified as neuroendocrine carcinoma along with carcinoid tumor, atypical carcinoid tumor, and large cell neuroendocrine tumor [3].…”

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The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix

Zhao,

Sun,

Yang

et al. 2024

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Small-cell neuroendocrine carcinoma of the cervix (SCNCC) is a rare and aggressive tumor with a poor prognosis. Surgical resection followed by adjuvant therapy is the standard treatment for early-stage disease but the influence of different neo/adjuvant treatment approaches remains unclear. Retrospectively, we collected patients' characteristics and treatments in two medical centers. Disease status and survival outcomes were renewed through follow-up. Statistics analysis mainly included Kaplan-Meier methods for survival curve estimation, log-rank test for survival curve comparison, and Cox proportional hazards models for independent prognostic factors prediction. Finally, 51 patients treated by radical surgery between January 2010 and April 2020 were enrolled with a median age of 50 years (range: 32-68). 12 (23.5%) patients were at stage IIIC1 according to the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging systems and the rest were at the early stage. The mean tumor size was 3.6±1.3 cm. Pathological examination found 24 cases with pure SCNCC and 27 cases with admixed SCCC. 29 (56.9%) patients had deep stromal infiltration and 19 (37.3%) patients had lymphovascular space invasion. 34 (66.7%) patients received neo/adjuvant chemotherapy and pelvic radiation was conducted in 41 (80.39%) patients with a median dose of 46 Gy (range: 40-50.4 Gy). The median follow-up time was 25.0 months. The median disease-free survival (DFS) time was 23.0 months. 27 (52.9%) patients developed distant metastasis and 14 (27.5%) experienced local failure. The median overall survival (OS) was 32.0 months. Univariate and multivariate analysis showed neoadjuvant chemotherapy as negative (HR=2.081, 95% CI 1.030-4.203, p=0.041) and adjuvant chemotherapy (HR=0.409, 95% CI 0.213-0.784, p=0.020) as positive independent prognostic factor for DFS. For OS, only lymph node metastasis was confirmed as an independent prognostic factor in both univariate analysis (HR=1.528, 95% CI 1.011-2.308, p=0.044) and multivariate analysis (HR=1.697, 95% CI 1.041-2.768, p=0.034). In conclusion, for surgically treated SCNCC, adjuvant chemotherapy showed a positive influence on DFS while neoadjuvant chemotherapy harmed DFS. OS was unaffected by either treatment choice.

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Exploring the ‘Rare’: A Comprehensive Analysis of the Rare Malignant Cervical Tumors in a Tertiary Cancer Care Institute of Northeast India

Begum,

Kumar,

Baruah

et al. 2024

Indian J Gynecol Oncolog

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Introduction The WHO 2020 classification of tumors of the female genital tract has adopted the dualistic classification of cervical squamous and adenocarcinoma into HPV–HPV-associated and HPV–HPV-independent types. However, the separate discussion on 'rare' varieties of cervical cancer is significant as it allows us to delve into their risk factors and natural course of disease and define any alternative treatment strategies to improve outcomes. Objectives To estimate the factors associated with histologically proven rare malignant tumors of the cervix and the overall survival of rare malignant cervical tumors in a tertiary care institute of Northeast India (NEI). Methods Our tertiary care institute in Northeast India, a region with unique healthcare challenges, including a high incidence of cervical cancers, conducted this retrospective study from 01/01/2018 to 31/12/2022. It excluded patients with incomplete records, squamous and adenocarcinoma histology, and metastatic cancer to the cervix. We collected demographic and survival data and performed survival analysis using SPSS 29.0. Results Out of 2367 diagnosed cervical cancer patients, 45 patients (1.9%) were diagnosed with rare cancer. Adenosquamous (0.7%) was the leading histology, followed by small cell NET (0.59%) and clear cell carcinoma (0.33%) in rare cervical cancer. Bleeding per vaginum was the presenting symptom in 91%. More than 80% of patients had a short duration of illness (< 6 months). Stage III (42%), followed by Stage II (27%), Stage IV (21%), and Stage I (10%) were presenting stages. A final diagnosis in 72% of histology required immunohistochemistry (IHC). Most of the patient (65%) did not complete their treatment. Conclusion This study's findings underscore the need for collective efforts in studying rare cancers, which can significantly enhance treatment strategies and improve the overall prognosis and quality of life for individuals affected.

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Small Cell and Other Rare Histologic Types of Cervical Cancer

Cited by 4 publications

References 62 publications

A Review with a Focus on Vaccinium-Berries-Derived Bioactive Compounds for the Treatment of Reproductive Cancers

A Review with a Focus on Vaccinium-Berries-Derived Bioactive Compounds for the Treatment of Reproductive Cancers

The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix

Exploring the ‘Rare’: A Comprehensive Analysis of the Rare Malignant Cervical Tumors in a Tertiary Cancer Care Institute of Northeast India

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