Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study

Toft-Petersen, Anne Pernille; Tilsted, Hans Henrik; Aarøe, Jens; Rasmussen, Klaus; Christensen, T.; Griffin, Bruce A.; Aardestrup, Inge Valbak; Andreasen, Arne; Schmidt, Erik Berg

doi:10.1186/1476-511x-10-21

Cited by 42 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous studies have reported that sdLDL is strongly associated with CVDs 2-4, 13, 23,26,27,[36][37][38][39][40][41] . A recent study investigating the association of cellular carotid plaque composition with cholesterol concentrations in lipoprotein sub-fractions evaluated by density gradient ultracentrifugation reported that the cholesterol content in the sdLDL fraction, but not the plasma LDL-C or HDL-C positively correlated with present study compared sdLDL-C to LDL-C, non-HDL-C, triglyceride, apolipoprotein B, lipoprotein(a), RLP-C, HDL-C, LDL-C/HDL-C ratio, and apolipoprotein A1 in the fasting state.…”

Section: Discussionmentioning

confidence: 99%

Elevated Small Dense Low-Density Lipoprotein Cholesterol as a Predictor for Future Cardiovascular Events in Patients with Stable Coronary Artery Disease

Nishikura

Koba

Yokota

et al. 2014

JAT

View full text Add to dashboard Cite

Aim:The aim of the present study was to investigate how small dense low-density lipoprotein cholesterol (sdLDL-C) compared with LDL-C affect the long-term prognosis in patients with stable coronary artery disease (CAD). Methods: sdLDL-C measured by heparin magnesium precipitation and LDL particle size measured by non-denatured gradient-gel electrophoresis were compared in 190 consecutive CAD patients who underwent coronary arteriography between 2003 and 2004 who did or did not develop cardiovascular events during a seven-year follow-up period. Cardiovascular events were death caused by cardiovascular diseases (CVDs), onset of acute coronary syndrome, need for coronary and peripheral arterial revascularization, hospitalization for heart failure, surgical procedure for any CVDs, and/or hospitalization for stroke. Results: First-time cardiovascular events were observed in 72 patients. Those who experienced cardiovascular events were older and had higher prevalence rates of hypertension and diabetes; significantly higher Gensini coronary atherosclerotic scores; significantly higher levels of sdLDL-C, sdLDL-C/LDL-C, and LDL-C/high-density lipoprotein cholesterol (HDL-C) ratios; and greater glycated hemoglobin (Hb)A1c and brain natriuretic peptide (BNP) levels. They also had significantly smaller LDL particle sizes, HDL-C, apolipoprotein A-1, and estimated glomerular filtration rate (GFR) compared with patients without cardiovascular events. Conversely, LDL-C, non-HDL-C, apolipoprotein B, remnantlike particle cholesterol, and high-sensitivity C-reactive protein (hs-CRP) levels were similar between the two groups. A Kaplan-Meyer event-free survival curve demonstrated that patients with sdLDL-C ≥ 35 mg/dL (median level) had significantly poorer prognosis compared with those with lower sdLDL-C levels, while patients with LDL-C ≥ 100 mg/dL had a non-significantly lower survival rate. Conclusion: These results confirm that sdLDL-C is a very promising biomarker to predict future cardiovascular events in the secondary prevention of stable CAD. J Atheroscler Thromb, 2014; 21:755-767.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated Small Dense Low-Density Lipoprotein Cholesterol as a Predictor for Future Cardiovascular Events in Patients with Stable Coronary Artery Disease

Nishikura

Koba

Yokota

et al. 2014

JAT

View full text Add to dashboard Cite

show abstract

“…Upon entry to the study, height, weight, and waist circumference (at the level of superior iliac risk factor ( 9 ), but 30-40% of patients with cardiovascular events have normal LDL-c levels ( 10 ). Therefore, patients with CAD may have small dense pattern B despite having normal LDL-c levels ( 11,12 ). This fi nding represents a potential source of unrecognized atherogenic risk when using a routine lipid panel instead of measuring LDL subfractions.…”

Section: Measurementsmentioning

confidence: 99%

Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia

Malhotra

Tonorezos

Rozenberg

et al. 2012

Journal of Lipid Research

View full text Add to dashboard Cite

Supplementary key words cancer • dyslipidemias • lipids • lipoproteins • LDL subfractionsAcute lymphoblastic leukemia (ALL) constitutes more than 80% of newly diagnosed acute leukemias in children and has a current fi ve-year overall survival rate exceeding 85 percent ( 1 ). At the same time, data from the Childhood Cancer Survivor Study (CCSS) suggest that adult survivors of childhood leukemia are at signifi cantly increased risk for myocardial infarction [Hazard rate (HR) 3.3; 95% CI, range 1.2-8.6 ] and congestive heart failure (HR 4.2; 95% CI, range 2.3-7.4) compared with their noncancer siblings ( 2, 3 ). Therefore, it is imperative to identify potential cardiac risk factors in this population at an early stage in the atherosclerotic process.Low-density lipoprotein (LDL) is composed of multiple subfractions based on particle size and density. Among these LDL subfractions, small dense LDL is more atherogenic than larger particles ( 4 ) and is associated with an increased risk for coronary artery disease (CAD) ( 5 ). There are two main subclass patterns of LDL based on predominant LDL particle size: large, buoyant LDL pattern A (particle diameter у 25 nm) and small dense LDL pattern B (particle diameter < 25 nm) ( 6 ). LDL pattern B is independently associated with higher rate of CAD progression

show abstract

“…sdLDL is more susceptible to oxidation producing oxidized LDL (oxLDL). Thus sdLDL is more atherogenic and has been shown to be a strong predictor of CHD, while large buoyant LDL is not (Toft-Petersen et al, 2011;Hoogeveen et al, 2014).…”

Section: "Saturated Fat" and "Animal Fat" In The Scientific Literaturementioning

confidence: 99%

A Half-Truth is Not the Whole Truth: The AHA Position on Saturated Fat

Dayrit

2017

KIMIKA

View full text Add to dashboard Cite

This second in this series of papers will present the biases in the American Heart Association's 2017 Presidential Advisory with respect to saturated fat. Although important differences in the metabolic properties of specific SFA have been known since the 1960s, the AHA still considers all SFA as one group having the same properties. There is abundant research available that supports the designation of C6 to C12 fatty acids as medium-chain fatty acids (MCFA). This is particularly relevant to coconut oil, which is made up of about 65% MCFA. Ignoring the evidence, AHA simply labels coconut oil as SFA. The AHA promotes half-truths, not the whole truth.

show abstract

Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study

Cited by 42 publications

References 25 publications

Elevated Small Dense Low-Density Lipoprotein Cholesterol as a Predictor for Future Cardiovascular Events in Patients with Stable Coronary Artery Disease

Elevated Small Dense Low-Density Lipoprotein Cholesterol as a Predictor for Future Cardiovascular Events in Patients with Stable Coronary Artery Disease

Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia

A Half-Truth is Not the Whole Truth: The AHA Position on Saturated Fat

Contact Info

Product

Resources

About