Small-diameter decellularized vascular graft with electrospun polycaprolactone

Cuenca, John Patrick; Padalhin, Andrew R.; Lee, Byong‐Taek

doi:10.1016/j.matlet.2020.128973

Cited by 15 publications

(3 citation statements)

References 8 publications

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“…In this study, polycaprolactone (PCL) were chosen as coating of β‐TCP module, because it possesses wonderful biocompatibility and similar mechanical property to natural extracellular matrix. [ 12 ] The PCL/β‐TCP modules were prepared to load chondrocytes in expectation of simulating physiological microenvironment of cartilage tissue. As shown in Figure S6G (Supporting Information), PCL was homogeneously coated on the β‐TCP modules via soaking method.…”

Section: Resultsmentioning

confidence: 99%

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

Yu,

Ma,

Wang

et al. 2024

Advanced Materials

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The behavior of tissue resident cells can be influenced by the spatial arrangement of cellular interactions. Therefore, it is of significance to precisely control the spatial organization of various cells within multicellular constructs. It remains challenging to construct a versatile multicellular scaffold with ordered spatial organization of multiple cell types. Herein, a modular multicellular tissue engineering scaffold with ordered spatial distribution of different cell types is constructed by assembling varying cell‐laden modules. Interestingly, the modular scaffolds can be disassembled into individual modules to evaluate the specific contribution of each cell type in the system. Through assembling cell‐laden modules, the macrophage‐mesenchymal stem cell (MSC), endothelial cell‐MSC and chondrocyte‐MSC co‐culture models are successfully established. The in vitro results indicate that the intercellular cross‐talk can promote the proliferation and differentiation of each cell type in the system. Moreover, MSCs in the modular scaffolds might regulate the behavior of chondrocytes through the nuclear factor of activated T‐Cells (NFAT) signaling pathway. Furthermore, the modular scaffolds loaded with co‐cultured chondrocyte‐MSC exhibit enhanced regeneration ability of osteochondral tissue, compared with other groups. Overall, this work offers a promising strategy to construct a multicellular tissue engineering scaffold for the systematic investigation of intercellular cross‐talk and complex tissue engineering.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

Yu,

Ma,

Wang

et al. 2024

Advanced Materials

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“…However, the limitation of this scaffold fabrication technique is lack of sustainable resources, difficulties in establishing a reproducible protocol, batch-to-batch variations, and possible alterations of ECM characteristics [ 6 ]. Most of the resulting vessels from this approach are also limited to mm-scale inner diameters, where constructs with the smallest dimensions have inner diameters of around 1 mm [ 229 , 230 ]. Nevertheless, there are continuous developments in the areas of decellularized vascular grafts such as comparison of scaffolds from different origins and further clinical investigation of long-term endothelialization [ 231 , 232 ].…”

Section: Fabrication Techniques On 3d Engineered Blood Vesselsmentioning

confidence: 99%

Biofabrication of engineered blood vessels for biomedical applications

Laowpanitchakorn,

Zeng,

Piantino

et al. 2024

Science and Technology of Advanced Materials

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To successfully engineer large-sized tissues, establishing vascular structures is essential for providing oxygen, nutrients, growth factors and cells to prevent necrosis at the core of the tissue. The diameter scale of the biofabricated vasculatures should range from 100 to 1,000 µm to support the mm-size tissue while being controllably aligned and spaced within the diffusion limit of oxygen. In this review, insights regarding biofabrication considerations and techniques for engineered blood vessels will be presented. Initially, polymers of natural and synthetic origins can be selected, modified, and combined with each other to support maturation of vascular tissue while also being biocompatible. After they are shaped into scaffold structures by different fabrication techniques, surface properties such as physical topography, stiffness, and surface chemistry play a major role in the endothelialization process after transplantation. Furthermore, biological cues such as growth factors (GFs) and endothelial cells (ECs) can be incorporated into the fabricated structures. As variously reported, fabrication techniques, especially 3D printing by extrusion and 3D printing by photopolymerization, allow the construction of vessels at a high resolution with diameters in the desired range. Strategies to fabricate of stable tubular structures with defined channels will also be discussed. This paper provides an overview of the many advances in blood vessel engineering and combinations of different fabrication techniques up to the present time.

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“…But the availability of suitable artificial blood vessels is limited. Recently, decellularized blood vessels have been found to have good vascular properties. − …”

Section: The Application Of Decellularized Scaffolds In Tissue Engine...mentioning

confidence: 99%

Biomedical Application of Decellularized Scaffolds

Zhang,

Gao,

Jiang

et al. 2023

ACS Appl. Bio Mater.

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Small-diameter decellularized vascular graft with electrospun polycaprolactone

Cited by 15 publications

References 8 publications

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

Biofabrication of engineered blood vessels for biomedical applications

Biomedical Application of Decellularized Scaffolds

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