Small Drosophila zinc finger C2H2 protein with an N-terminal zinc finger-associated domain demonstrates the architecture functions

Maksimenko, Oksana; Kyrchanova, Olga; Klimenko, Natalia; Zolotarev, Nikolay; Elizarova, A. N.; Bonchuk, Artem; Georgiev, Pavel

doi:10.1016/j.bbagrm.2019.194446

Cited by 26 publications

(29 citation statements)

References 80 publications

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“…2) четыре-пять С2Н2-доменов, образующих кластер [171,[183][184][185][186]. За исключением Su(Hw) сайты связывания С2Н2-белков локализованы преимущественно в области промоторов активных генов и интронов [177,[184][185][186][187][188][189][190]. Наиболее показательным примером белка данного класса является М1ВР, который связывается с промоторами более 2000 генов [185] и, согласно экспериментальным данным [191], участвует в наведении зон открытого хроматина и привлечении основного промоторного комплекса.…”

Section: другие с2н2-белки позвоночных с архитектурными функциямиunclassified

CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers

et al. 2021

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In mammals, most of the boundaries of topologically associating domains and all well-studied insulators are rich in binding sites for the CTCF protein. According to existing experimental data, CTCF is a key factor in the organization of the architecture of mammalian chromosomes. A characteristic feature of the CTCF is that the central part of the protein contains a cluster consisting of eleven domains of C2H2-type zinc fingers, five of which specifically bind to a long DNA sequence conserved in most animals. The class of transcription factors that carry a cluster of C2H2-type zinc fingers consisting of five or more domains (C2H2 proteins) is widely represented in all groups of animals. The functions of most C2H2 proteins still remain unknown. This review presents data on the structure and possible functions of these proteins, using the example of the vertebrate CTCF protein and several well- characterized C2H2 proteins in Drosophila and mammals.

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Section: другие с2н2-белки позвоночных с архитектурными функциямиunclassified

CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers

et al. 2021

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“…2006 ( Chen et al, 2006 ) Kahsai et al G3 2018 ( Kahsai and Cook, 2018 ) Lake et al PLoS Genet. 2011 ( Lake et al, 2011 ) Zhang et al Genetics 2007 ( Zhang et al, 2007 ) Maksimenko et al Biochim Biophys Acta 2020 ( Maksimenko et al, 1863 ) Zolotarev et al BioTechniques 2019 ( Zolotarev et al, 2019 ) Neumüller et al Cell Stem Cell 2011 ( Neumüller et al, 2011 ) Nazario-Yepiz et al Mech. Dev.…”

Section: Additional Filesmentioning

confidence: 99%

Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

Kasinathan

Colmenares

McConnell

et al. 2020

eLife

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Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential functions in Drosophila melanogaster than ancient, conserved ZAD-ZNF genes. We focus on the Nicknack ZAD-ZNF gene, which is evolutionarily young, poorly retained in Drosophila species, and evolves under strong positive selection. Yet we find that it is necessary for larval development in D. melanogaster. We show that Nicknack encodes a heterochromatin-localizing protein like its paralog Oddjob, also an evolutionarily dynamic yet essential ZAD-ZNF gene. We find that the divergent D. simulans Nicknack protein can still localize to D. melanogaster heterochromatin and rescue viability of female but not male Nicknack-null D. melanogaster. Our findings suggest that innovation for rapidly changing heterochromatin functions might generally explain the essentiality of many evolutionarily dynamic ZAD-ZNF genes in insects.

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“…An important feature of ZADs is their preferentially ability to homodimerize into an antiparallel dimer [147,151]. In addition to Pita, several other ZAD-C2H2 proteins, including ZIPIC (Zinc-finger protein interacting with CP190), Zw5 (Zeste-white 5), and ZAF1, have been shown to support distance interactions and form functional insulators [137,[152][153][154][155]. Mutational analysis, in vivo, showed that the presence of ZADs determined the ability of these proteins to support distance interactions [154,155].…”

Section: Super-long-distance Interactions In the Drosophila Genome Anmentioning

confidence: 99%

Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes

Georgiev¹,

Kyrchanova²

2020

Preprint

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In higher eukaryotes, enhancers determine the activation of developmental gene transcription in specific cell types and stages of embryogenesis. Enhancers transform the signals produced by various transcription factors within a given cell, activating the transcription of the targeted genes. Often, developmental genes can be associated with dozens of enhancers, some of which are located at large distances from the promoters that they regulate. Currently, the mechanisms that underly the specific distance interactions between enhancers and promoters remain unknown. This review describes the properties and activities of enhancers and discusses the mechanisms of distance interactions and potential proteins involved in this process.

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Small Drosophila zinc finger C2H2 protein with an N-terminal zinc finger-associated domain demonstrates the architecture functions

Cited by 26 publications

References 80 publications

CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers

CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers

Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes

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