Small for Gestational Age and Intrauterine Growth Restriction Decreases Cognitive Function in Young Adults

Løhaugen, Gro; Østgård, Heidi Furre; Andreassen, Silje Malen; Jacobsen, Geir; Vik, Torstein; Brubakk, Ann‐Mari; Skranes, Jon; Martinussen, Marit

doi:10.1016/j.jpeds.2013.01.060

Cited by 105 publications

(70 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a review from 2010, de Bie et al showed a subtle but statistically significant decrease in intelligence level and cognitive disabilities in children born SGA, even though different definitions of SGA make comparisons more difficult [10]. Other studies, with smaller cohorts, have shown results similar to ours, with a small but statistically increased risk of poor school performance and lower intelligence levels for children born SGA, but without looking at different levels of SGA within the same population [11, 31-33]. We are only aware of one previous study that used multiple thresholds reflecting different severity classes of SGA when studying learning difficulties.…”

Section: Discussionsupporting

confidence: 52%

Born Small for Gestational Age and Poor School Performance – How Small Is Too Small?

et al. 2017

View full text Add to dashboard Cite

Aim: To assess the relationship between severity of small for gestational age (SGA) and the risk of poor school performance, and to investigate whether adult stature modifies this risk. Methods: 1,088,980 Swedish children born at term between 1973 and 1988 were categorized into severe SGA (less than –3 standard deviations (SD) of expected birth weight), moderate SGA (–2.01 to –3 SD), mild SGA (–1.01 to –2 SD), and appropriate for gestational age (–1 to 0.99 SD). The risk of poor school performance at the time of graduation from compulsory school (grades <10th percentile) was calculated using unconditional logistic regression models and adjusted for socio-economic factors. In a sub-analysis, we stratified boys by adult stature, and adjusted for maternal but not paternal height. Results: All SGA groups were significantly associated with an increased risk of poor school performance, with adjusted odds ratios and 95% confidence intervals ranging from 1.85 (1.65–2.07) for severe SGA to 1.25 (1.22–1.28) for mild SGA. In the sub-analysis, all birth weight groups were associated with an increased risk of poor school performance among boys with short stature compared to those with non-short stature. Conclusion: Mild SGA is associated with a significantly increased risk of poor school performance, and the risk increases with severity of SGA. Further, this risk diminishes after adequate catch-up growth.

show abstract

Section: Discussionsupporting

confidence: 52%

Born Small for Gestational Age and Poor School Performance – How Small Is Too Small?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…low birth weight in humans [30,39,42,148], existing studies do suggest long-term structural 283 damage following experimental IUGR. These include damage which occurs during exposure to 284 restriction and persist from fetal life, such as decreased neuronal density [117], which can be 285 contributed by grey matter loss in utero resulting in decreased neuron numbers in later life.…”

mentioning

confidence: 99%

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Hunter

Hazel

Kind

et al. 2016

Physiology & Behavior

View full text Add to dashboard Cite

After the embargo period via non-commercial hosting platforms such as their institutional repository  via commercial sites with which Elsevier has an agreement In all cases accepted manuscripts should: link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article

show abstract

“…La relación entre la función cognitiva y el retardo del crecimiento intrauterino también ha sido estudiada en adultos nacidos con dicho retardo, que alcanzaron puntuaciones IQ significativamente menores que sus pares sin retardo del crecimiento intrauterino (diferencia media -6.3). 21 Asfixia perinatal: la asfixia perinatal es una de las principales causas de morbilidad y mortalidad perinatales. La lesión cerebral por asfixia perinatal se debe a la hipoxia e isquemia cerebral que finalmente llevan a disfunción cerebral y muerte neuronal.…”

Section: Factores Pre Y Perinatalesunclassified

Riesgo neurológico en el niño de mediano riesgo neonatal

Vericat

Orden

2017

Acta Pediatr Mex

View full text Add to dashboard Cite

255www.actapediatrica.org.mx Artículo de revisión Acta Pediatr Mex. 2017 jul;38(4):255-266. Riesgo neurológico en el niño de mediano riesgo neonatalResumen INTRODUCCIÓN: los neonatos de mediano riesgo suelen presentar alteraciones del neurodesarrollo, sutiles o inaparentes, que pueden evidenciarse a mediano y a largo plazos; es por ello que se les considera niños de riesgo neurológico. La identificación de los factores de riesgo asociados con los problemas del neurodesarrollo es un primer paso para prevenir o reducir sus efectos.OBJETIVO: con esta revisión cualitativa de la literatura especializada pretendemos describir las características de un grupo de neonatos denominados colectivamente recién nacidos de mediano riesgo neonatal y que, al nacer, no presentan compromiso evidente del desarrollo neurológico. Indagamos, también sobre los factores etiológicos asociados con esta condición. MATERIALES Y MÉTODOS:realizamos una búsqueda bibliográfica en las bases Scientific Electronic Library Online (SciELO), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS), la Biblioteca Nacional de Medicina de Estados Unidos de Norte América (NLM-Medline) y la Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (RedALyC) centrada en factores de riesgo neurológico.RESULTADOS: el incremento de los controles prenatales, la reducción de los nacimientos pretérmino y del parto por cesárea son factores relevantes para el óptimo neurodesarrollo. Luego del parto es necesario extremar los cuidados del neonato en las Unidades de Cuidado Intensivo Neonatal controlando cuadros tales como la hiperbilirrubinemia, la sepsis neonatal y la dificultad respiratoria, asociados con alteraciones del desarrollo en los neonatos de mediano riesgo.CONCLUSIONES: las intervenciones para evitar o reducir el riesgo neurológico en los neonatos de mediano riesgo deben establecerse desde el inicio de la gestación y continuar durante toda la permanencia en las Unidades de Cuidado Intensivo Neonatal.PALABRAS CLAVE: recién nacido, trastornos del neurodesarrollo, factores de riesgo, neonatología, desarrollo infantil. OBJECTIVE:To describe the characteristics of a group of newborns collectively referred to as moderate-risk neonates, who at birth do not show neurodevelopmental disorders, and to investigate the etiological factors associated with this condition. METHODS:We carried a bibliographic search was performed in the SciELO, LILACS, Medline and RedALyC databases focused on neurological risk factors. RESULTS:Increased prenatal control and the reduction of preterm and cesarean delivery are important factors for optimal neurodevelopment. After delivery, newborn care in NICUs is critical, by controlling pathologies such as hyperbilirubinemia, neonatal sepsis, and respiratory distress associated with developmental abnormalities in MRN. CONCLUSIONS:Interventions to avoid or reduce neurological risk in MRN must be established from the beginning of pregnancy and continued during the NICU stay.

show abstract

Small for Gestational Age and Intrauterine Growth Restriction Decreases Cognitive Function in Young Adults

Cited by 105 publications

References 27 publications

Born Small for Gestational Age and Poor School Performance – How Small Is Too Small?

Born Small for Gestational Age and Poor School Performance – How Small Is Too Small?

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Riesgo neurológico en el niño de mediano riesgo neonatal

Contact Info

Product

Resources

About