Small interfering RNAs: heralding a new era in gene therapy

Overcoming the protein corona in chitosan-based nanoparticles

“…Finally, DNA aptamers were employed as targeting moieties and designed against the tumour marker MUC1, a mucin glycoprotein overexpressed in several epithelial cancer cells such as colon cancer cells [67]. Since aptamers have a low MW (6 -24 kDa), the RES barely recognized them, allowing NPs to have a longer circulation time [68]. The formation of a protein corona on NPs was evaluated following their incubation with either 10% or 100% FBS.…”