Small intestinal bacterial overgrowth: current update

Zafar, Hammad; Jimenez, Brenda; Schneider, Alison

doi:10.1097/mog.0000000000000971

Cited by 7 publications

(2 citation statements)

References 75 publications

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“…Antimicrobial agents, such as rifaximin (550 mg, three times a day), metronidazole (250–500 mg, three times a day), or doxycycline (100 mg, twice a day), administered periodically may be helpful in neutralizing the effects of SIBO, a condition associated with various gastrointestinal symptoms, as well as nutrient deficiencies, and weight loss [ 114 , 115 ]. It has recently been shown that the bioavailability of oral antibiotics was higher than expected in patients who have suffered a loss of their anatomical surface area for absorption [ 116 ].…”

Section: Short Bowel Syndrome (Sbs)mentioning

confidence: 99%

Metabolic and Nutritional Issues after Lower Digestive Tract Surgery: The Important Role of the Dietitian in a Multidisciplinary Setting

Utrilla Fornals,

Costas-Batlle,

Medlin

et al. 2024

Nutrients

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Many patients undergo small bowel and colon surgery for reasons related to malignancy, inflammatory bowel disease (IBD), mesenteric ischemia, and other benign conditions, including post-operative adhesions, hernias, trauma, volvulus, or diverticula. Some patients arrive in the operating theatre severely malnourished due to an underlying disease, while others develop complications (e.g., anastomotic leaks, abscesses, or strictures) that induce a systemic inflammatory response that can increase their energy and protein requirements. Finally, anatomical and functional changes resulting from surgery can affect either nutritional status due to malabsorption or nutritional support (NS) pathways. The dietitian providing NS to these patients needs to understand the pathophysiology underlying these sequelae and collaborate with other professionals, including surgeons, internists, nurses, and pharmacists. The aim of this review is to provide an overview of the nutritional and metabolic consequences of different types of lower gastrointestinal surgery and the role of the dietitian in providing comprehensive patient care. This article reviews the effects of small bowel resection on macronutrient and micronutrient absorption, the effects of colectomies (e.g., ileocolectomy, low anterior resection, abdominoperineal resection, and proctocolectomy) that require special dietary considerations, nutritional considerations specific to ostomized patients, and clinical practice guidelines for caregivers of patients who have undergone a surgery for local and systemic complications of IBD. Finally, we highlight the valuable contribution of the dietitian in the challenging management of short bowel syndrome and intestinal failure.

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Section: Short Bowel Syndrome (Sbs)mentioning

confidence: 99%

Metabolic and Nutritional Issues after Lower Digestive Tract Surgery: The Important Role of the Dietitian in a Multidisciplinary Setting

Utrilla Fornals,

Costas-Batlle,

Medlin

et al. 2024

Nutrients

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“…There is also an important role in the process for small intestinal bacterial overgrowth (SIBO), which is defined as an increase in the content of bacteria in the small intestine of more than 100,000 cells per mL [37][38][39][40]. An increase in the bacterial population of the small intestine also can lead to bacterial translocation, promoting liver fibrosis.…”

Section: Gut Microbiota In Normal and Pathological Conditionsmentioning

confidence: 99%

Gut Microbiota and Bacterial Translocation in the Pathogenesis of Liver Fibrosis

Maslennikov,

Poluektova,

Zolnikova

et al. 2023

IJMS

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Cirrhosis is the end result of liver fibrosis in chronic liver diseases. Studying the mechanisms of its development and developing measures to slow down and regress it based on this knowledge seem to be important tasks for medicine. Currently, disorders of the gut–liver axis have great importance in the pathogenesis of cirrhosis. However, gut dysbiosis, which manifests as increased proportions in the gut microbiota of Bacilli and Proteobacteria that are capable of bacterial translocation and a decreased proportion of Clostridia that strengthen the intestinal barrier, occurs even at the pre-cirrhotic stage of chronic liver disease. This leads to the development of bacterial translocation, a process by which those microbes enter the blood of the portal vein and then the liver tissue, where they activate Kupffer cells through Toll-like receptor 4. In response, the Kupffer cells produce profibrogenic cytokines, which activate hepatic stellate cells, stimulating their transformation into myofibroblasts that produce collagen and other elements of the extracellular matrix. Blocking bacterial translocation with antibiotics, probiotics, synbiotics, and other methods could slow down the progression of liver fibrosis. This was shown in a number of animal models but requires further verification in long-term randomized controlled trials with humans.

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Preguntas comunes y respuestas razonadas sobre el síndrome del sobrecrecimiento bacteriano intestinal (SIBO)

Alcedo González,

Estremera-Arévalo,

Cobián Malaver

et al. 2024

Gastroenterología y Hepatología

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Small intestinal bacterial overgrowth: current update

Cited by 7 publications

References 75 publications

Metabolic and Nutritional Issues after Lower Digestive Tract Surgery: The Important Role of the Dietitian in a Multidisciplinary Setting

Metabolic and Nutritional Issues after Lower Digestive Tract Surgery: The Important Role of the Dietitian in a Multidisciplinary Setting

Gut Microbiota and Bacterial Translocation in the Pathogenesis of Liver Fibrosis

Preguntas comunes y respuestas razonadas sobre el síndrome del sobrecrecimiento bacteriano intestinal (SIBO)

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