Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections

Xie, Yun; Zhang, Qiang; Zheng, Wenfu; Jiang, Xingyu

doi:10.1021/acsami.1c04944

Cited by 20 publications

(11 citation statements)

References 39 publications

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“…As hemolysis can hamper the application of (1,4-DBTPP)Br 2 in vivo, we further evaluated its blood compatibility. 51 After incubation with fresh mouse blood, (1,4-DBTPP)Br 2 at concentrations as high as 2048 μg mL −1 did not induce hemolysis (Figure 6B). These results demonstrate that (1,4-DBTPP)Br 2 exhibits excellent biocompatibility.…”

Section: Cytotoxicity and Hemolysis Assaymentioning

confidence: 91%

Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing

Shi¹,

Zhuang²,

Wang³

et al. 2023

IJN

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Background: Drug-resistant microbes pose a global health concern, requiring the urgent development of effective antibacterial agents and strategies in clinical practice. Therefore, there is an urgent need to explore novel antibacterial materials to effectively eliminate bacteria. The synthesis of quaternary phosphonium salt in haloargentate systems, wherein the phosphorus atom is represented in a cationic form, is a possible strategy for the development of antibacterial materials. Methods: Using (triphenyl)phosphonium-based quaternary phosphorus salts with different spacer lengths (n=2, 4, 6) as a template, we designed three kinds of quaternary phosphorus salts as effective antibacterial agents against drug-resistant bacteria. Results:The synthesized quaternary phosphorus salt of (1,4-DBTPP)Br 2 effectively prevented the formation of the bacterial biofilms, and degraded bacterial membranes and cell walls by promoting the production of reactive oxygen species, which exhibited effective therapeutic effects in a rat model of a superficial wound infected with methicillin-resistant Staphylococcus aureus. Conclusion:The quaternary phosphorus salt (1,4-DBTPP)Br 2 demonstrated hemocompatibility and low toxicity, revealing its potential in the treatment of clinical infections.

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Section: Cytotoxicity and Hemolysis Assaymentioning

confidence: 91%

Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing

Shi¹,

Zhuang²,

Wang³

et al. 2023

IJN

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“…The latest studies have demonstrated that, in addition to the excellent physical and chemical properties, pep-AuNCs also exhibit unique intrinsic bioactivities and show good potential in the field of disease diagnosis and treatment [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. AuNCs have been reported to prevent and treat skin infections due to their antimicrobial activity [ 22 , 23 ]. However, their immunomodulatory properties and therapeutic potential in inflammatory skin diseases, such as contact dermatitis and psoriasis, are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Peptide-Protected Gold Nanoclusters Efficiently Ameliorate Acute Contact Dermatitis and Psoriasis via Repressing the TNF-α/NF-κB/IL-17A Axis in Keratinocytes

Liu

Meng

et al. 2023

Nanomaterials

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Immune-mediated skin diseases have a high prevalence and seriously affect patients’ quality of life. Gold compounds have been considered promising therapeutic agents in dermatology, but the high incidence of adverse reactions have limited their clinical application. There is a great need to develop more effective and less toxic gold-based drugs. Gold nanoclusters fabricated by using peptides (pep-AuNCs) have appeared as potential biomedical nanomaterials because of their excellent biocompatibility, ease of fabrication and unique physicochemical properties. Glutathione (GSH) is an endogenous tripeptide and has been used for lightening the skin color. Therefore, we fabricated a well-defined gold nanocluster with GSH as an example to explore the immunomodulatory effect of AuNCs on a TNF-α-treated human keratinocyte cell line (HaCaT) in vitro, the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced irritant contact dermatitis (ICD) model and the oxazolone (OXA)-induced psoriatic model in vivo. The results indicated that topically applied AuNCs successfully attenuated the severity of ICD and psoriasis-like lesions. In vitro and in vivo, AuNCs effectively inhibited the abnormal activation of the NF-κB pathway and the consequent overexpression of proinflammatory cytokines in keratinocytes. In particular, the transactivation of IL-17A, the most important cytokine in psoriasis pathology, was effectively inhibited by AuNCs treatment. In addition, AuNCs did not show any obvious cytotoxicity in HaCaT cells at doses even up to 100 µM and did not induce any irritation in the healthy skin and major organs, which indicated their favorable biosafety. These results indicate that biocompatible pep-AuNCs might be a promising gold-based nanomedicine for the treatment of inflammatory skin diseases.

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“…The antibacterial effects of membranes were performed by liquid medium turbidity assays. 29 50 mg membrane was added to 2 mL LB liquid medium, which contained 1 × 10 6 CFU/mL bacteria in logarithmic growth phase. The liquid medium was incubated in a 37°C thermostat (Shanghai Zhicheng Analytical Instrument Manufacturing Co., Ltd. China), and the absorbance of bacterial suspensions at 625 nm was measured using an Epoch 2 microplate reader (American BioTek Instruments Co., Ltd. USA).…”

Section: In Vitro Assessmentsmentioning

confidence: 99%

Bletilla striata composite nanofibrous membranes prepared by emulsion electrospinning for enhanced healing of diabetic wounds

Zhao,

Hu,

Zhou

et al. 2023

J Biomater Appl

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Diabetic wounds impose enormous distress and financial burden on patients, and finding effective dressings to manage wounds is critical. As a Chinese herbal medicine with a long history of Clinical application, Bletilla striata has significant medicinal effects in the therapy of various wounds. In this study, PLA and the pharmacodynamic substances of Bletilla striata were prepared into fibrous scaffolds by emulsion electrospinning technology for the management of diabetic wounds in mice. The results of scanning electron microscopy showed that the core-shell structure fibre was successfully obtained by emulsion electrospinning. The fibre membrane exhibited excellent water absorption capability and water vapor transmission rate, could inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa, had good compatibility, and achieved excellent healing effect on diabetic wounds. Especially in the in vivo wound healing experiment, the wound healing rate of composite fibre membrane treatment reached 98.587 ± 2.149% in 16 days. This work demonstrated the good therapeutic effect of the developed fibrous membrane to diabetic wound, and this membrane could be potentially applied to chronic wound healing.

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Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections

Cited by 20 publications

References 39 publications

Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing

Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing

Peptide-Protected Gold Nanoclusters Efficiently Ameliorate Acute Contact Dermatitis and Psoriasis via Repressing the TNF-α/NF-κB/IL-17A Axis in Keratinocytes

Bletilla striata composite nanofibrous membranes prepared by emulsion electrospinning for enhanced healing of diabetic wounds

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