Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407

Santimetaneedol, A.; Wang, Z.; Arteaga, Daniel N; Aksit, Aykut; Prevoteau, C.; Yu, Michelle; Chiang, Harry; Lalwani, Anil K.; Kysar, Jeffrey W.

doi:10.1016/j.colsurfb.2019.06.030

Cited by 17 publications

(19 citation statements)

References 37 publications

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“…More recently, microperforations have been studied in combination with the thermoreversible hydrogel poloxamer 407 . Microperforations used in conjunction with a poloxamer increased the diffusion rate compared to the poloxamer alone.…”

Section: Optimal Inner Ear Delivery Methodsmentioning

confidence: 99%

“…69,74 More recently, microperforations have been studied in combination with the thermoreversible hydrogel poloxamer 407. 38 Microperforations used in conjunction with a poloxamer increased the diffusion rate compared to the poloxamer alone. However, these effects were limited; increased diffusion was only seen with microperforations of a certain size.…”

Section: Optimal Inner Ear Delivery Methodsmentioning

confidence: 99%

“…Creating microperforations in the RWM is a novel technique for mechanically increasing the permeability of the RWM. Small perforations have been shown to increase the diffusion of small molecules by more than 35‐fold across the RWM . Moreover, the increase in RWM permeability depends not on the variable intrinsic properties of the RWM but on characteristics of the microperforations themselves, such as the size of perforation .…”

Section: Recent Advances In Inner Ear Deliverymentioning

confidence: 99%

“…37,38 Moreover, the increase in RWM permeability depends not on the variable intrinsic properties of the RWM but on characteristics of the microperforations themselves, such as the size of perforation. 38 Thus, the ability to introduce microperforations in a controlled manner leads to the precise and reliable enhancement of RWM permeability. Microneedles are designed with the microanatomic and mechanical properties of the RWM in mind, to create controlled and precise perforations in the membrane with minimal trauma (Figure 3).…”

Section: Increasing Rwm Permeabilitymentioning

confidence: 99%

“…Small perforations have been shown to increase the diffusion of small molecules by more than 35‐fold across the RWM . Moreover, the increase in RWM permeability depends not on the variable intrinsic properties of the RWM but on characteristics of the microperforations themselves, such as the size of perforation . Thus, the ability to introduce microperforations in a controlled manner leads to the precise and reliable enhancement of RWM permeability.…”

Section: Recent Advances In Inner Ear Deliverymentioning

confidence: 99%

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Inner ear delivery: Challenges and opportunities

Szeto

Chiang

Valentini

et al. 2019

Laryngoscope Investig Oto

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Objectives The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation. Data Sources The databases used were PubMed, EMBASE, and Web of Science. Results Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants. Conclusions In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation. Level of Evidence NA

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Section: Optimal Inner Ear Delivery Methodsmentioning

confidence: 99%

Section: Optimal Inner Ear Delivery Methodsmentioning

confidence: 99%

Section: Recent Advances In Inner Ear Deliverymentioning

confidence: 99%

Section: Increasing Rwm Permeabilitymentioning

confidence: 99%

Section: Recent Advances In Inner Ear Deliverymentioning

confidence: 99%

See 3 more Smart Citations

Inner ear delivery: Challenges and opportunities

Szeto

Chiang

Valentini

et al. 2019

Laryngoscope Investig Oto

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Pyrolyzed Ultrasharp Glassy Carbon Microneedles

et al. 2022

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Polymeric microneedles fabricated via two‐photon polymerization (2PP) lithography enable safe medical access to the inner ear. Herein, the material class for 2PP‐lithography‐based microneedles is expanded by pyrolyzing 2PP‐fabricated polymeric microneedles, resulting in glassy carbon microneedles. During pyrolysis the microneedles shrink up to 81% while maintaining their complex shape when the exposed surface‐area‐to‐volume ratio (SVR) is 0.025

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Pyrolyzed Ultrasharp Glassy Carbon Microneedles

et al. 2022

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Glassy carbon microneedles are pyrolyzed from polymeric microneedles that are synthesized by two‐photon polymerization lithography as described in the article number http://doi.wiley.com/10.1002/adem.202201222 by Jeffrey W. Kysar and co‐workers. They enable precise and controlled perforation of a guinea pig’s round window membrane that separates the middle ear and inner ear spaces. The perforations open a potential pathway for the delivery of therapeutics into the inner ear to treat hearing and balance disorders.

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Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407

Cited by 17 publications

References 37 publications

Inner ear delivery: Challenges and opportunities

Inner ear delivery: Challenges and opportunities

Pyrolyzed Ultrasharp Glassy Carbon Microneedles

Pyrolyzed Ultrasharp Glassy Carbon Microneedles

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