Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

Abstract

This perspective article aims to introduce the design principles and recognition strategies of small-molecule fluorescent probes which are applied for the detection of gas signaling molecules including NO, CO and H2S in biological systems.

Cardiovascular bioimaging of nitric oxide: Achievements, challenges, and the future

“…Direct and indirect, fluorescence‐based, 62,63 chemiluminescence, ozone‐based chemiluminescence, 64 and nanophotonics 65 based methods have been developed to allow sensing, imaging, and qualitative detection of NO. These methods can be further categorized based on the chemical composition, 66 imaging modality, and biocompatibility of the associated sensor. A few, selected examples of studies involving vascular tissues or relevant cell types with these direct and surrogate NO sensors are summarized in Tables 1 and 2, respectively.…”

“…These methods can be further categorized based on the chemical composition, 66 , and various other exogenous NO donors (NOC) are used in therapeutic and experimental applications. Direct (left) and indirect (right) approaches to detect NO have been described.…”

Activatable fluorescence sensors forin vivobio-detection in the second near-infrared window

“…Fluorescence sensing of biochemical analytes has great potential in medical diagnosis and therapy assessment elds. [1][2][3][4][5][6] One ambitious goal of uorescence sensing is non-invasive monitoring and detection of physiological parameters or clinically relevant species. 7,8 It has been already possible to measure uorescence signals through the skin, and the measurement results can accurately reect the concentration of the analytes.…”

Recent Advances in Fluorescence Light‐Up Endogenous and Exogenous Carbon Monoxide Detection in Biology

“…[2] Up to now, several review articles are available, focusing on the development and detection of several small molecules together with carbon monoxide (CO) in a noninvasive manner. [31][32][33][34] But none of the above are dedicated to cellular non-targetable and targetable CO detection in living cells. In fact, no review is available in the literature at present on the said topic.…”

“…There is a recent review focusing on development of fluorescent probes for the detection of carbonyl species, formaldehyde, carbon monoxide (CO), and phosgene molecules . Up to now, several review articles are available, focusing on the development and detection of several small molecules together with carbon monoxide (CO) in a non‐invasive manner . But none of the above are dedicated to cellular non‐targetable and targetable CO detection in living cells.…”