Small molecule-mediated regenerative engineering for craniofacial and dentoalveolar bone

Mitchell, Juan; Lo, Kevin W.‐H.

doi:10.3389/fbioe.2022.1003936

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…It is worth noting that our findings underscore slightly better preservation of segmental kyphotic correction and intervertebral height in patients receiving group B treatments, stressing that the success of bone grafts in spinal reconstruction transcends biomechanical attributes to encompass biological behavior, such as osteoconduction, osteoinduction, and osteogenesis [ 39 – 41 ]. Rib bone grafts, which include cortical and cancellous components, are advantageous in reconstructive surgery for their accessibility and malleability for defect accommodation.…”

Section: Discussionmentioning

confidence: 83%

Comparative evaluation of multi-fold rib and structural iliac bone grafts in single-segment thoracic and thoracolumbar spinal tuberculosis: clinical and radiological outcomes

Luo,

Chen,

Xiu

et al. 2023

J Orthop Surg Res

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Objective To compare clinical and radiological outcomes of multi-fold rib and structural iliac bone grafts, the primary autologous graft techniques in anterolateral-only surgery for single-segment thoracic and thoracolumbar spinal tuberculosis. Methods This retrospective study included 99 patients treated from January 2014 to March 2022, categorized into 64 with multi-fold rib grafts (group A) and 35 with structural iliac bone grafts (group B). Outcomes assessed included hospital stay, operation time, intraoperative blood loss, postoperative drainage, complications, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the Visual Analog Scale (VAS) for pain, the Oswestry Disability Index (ODI), bone fusion time, and the American Spinal Injury Association (ASIA) impairment scale grade. Segmental kyphotic angle and intervertebral height were measured radiologically before surgery and follow-up. Results The mean follow-up was 63.50 ± 26.05 months for group A and 64.97 ± 26.43 months for group B (P > 0.05). All patients had achieved a clinical cure. Group A had a shorter operation time (P = 0.004). Within one week post-surgery, group B reported higher VAS scores (P < 0.0001). Neurological performance and quality of life significantly improved in both groups. No significant differences were observed in segmental kyphotic angle and intervertebral height between the groups pre- and postoperatively (P > 0.05). However, group A showed a greater segmental kyphotic angle at the final follow-up, while group B had better maintenance of kyphotic angle correction and intervertebral height (P < 0.05). Bone fusion was achieved in all patients without differences in fusion time (P > 0.05). Conclusions Multi-fold rib grafts resulted in shorter operation times and less postoperative pain, while structural iliac bone grafts provided better long-term maintenance of spinal alignment and stability, suggesting their use in cases where long-term outcomes are critical.

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Section: Discussionmentioning

confidence: 83%

Comparative evaluation of multi-fold rib and structural iliac bone grafts in single-segment thoracic and thoracolumbar spinal tuberculosis: clinical and radiological outcomes

Luo,

Chen,

Xiu

et al. 2023

J Orthop Surg Res

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“…The majority of the aforementioned limitations can be overcome using synthetic non-peptidic cell-adhesive small molecules that are capable of promoting cellular adhesion, differentiation, and survival both in vitro and in vivo (see Table 1 ) [ 35 ]. Often classified according to their chemical composition and clinical utility, many small molecules have been established as invaluable drugs with the purpose of preventing or ameliorating common acute and chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

The Use of Small-Molecule Compounds for Cell Adhesion and Migration in Regenerative Medicine

Mitchell,

2023

Biomedicines

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Cell adhesion is essential for cell survival, communication, and regulation, and it is of fundamental importance in the development and maintenance of tissues. Cell adhesion has been widely explored due to its many important roles in the fields of tissue regenerative engineering and cell biology. This is because the mechanical interactions between a cell and its extracellular matrix (ECM) can influence and control cell behavior and function. Currently, biomaterials for regenerative medicine have been heavily investigated as substrates for promoting a cells’ adhesive properties and subsequent proliferation, tissue differentiation, and maturation. Specifically, the manipulation of biomaterial surfaces using ECM coatings such as fibronectin extracted from animal-derived ECM have contributed significantly to tissue regenerative engineering as well as basic cell biology research. Additionally, synthetic and natural bioadhesive agents with pronounced abilities to enhance adhesion in numerous biological components and molecules have also been assessed in the field of tissue regeneration. Research into the use of facilitative bioadhesives has aimed to further optimize the biocompatibility, biodegradability, toxicity levels, and crosslinking duration of bioadhesive materials for improved targeted delivery and tissue repair. However, the restrictive drawbacks of some of these bioadhesive and animal-derived materials include the potential risk of disease transmission, immunogenicity, poor reproducibility, impurities, and instability. Therefore, it is necessary for alternative strategies to be sought out to improve the quality of cell adhesion to biomaterials. One promising strategy involves the use of cell-adhesive small molecules. Small molecules are relatively inexpensive, stable, and low-molecular-weight (<1000 Da) compounds with great potential to serve as efficient alternatives to conventional bioadhesives, ECM proteins, and other derived peptides. Over the past few years, a number of cell adhesive small molecules with the potential for tissue regeneration have been reported. In this review, we discuss the current progress using cell adhesive small molecules to regulate tissue regeneration.

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Current advancements in bio-ink technology for cartilage and bone tissue engineering

Badhe

Chatterjee

Bijukumar

et al. 2023

Bone

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Small molecule-mediated regenerative engineering for craniofacial and dentoalveolar bone

Cited by 5 publications

References 64 publications

Comparative evaluation of multi-fold rib and structural iliac bone grafts in single-segment thoracic and thoracolumbar spinal tuberculosis: clinical and radiological outcomes

Comparative evaluation of multi-fold rib and structural iliac bone grafts in single-segment thoracic and thoracolumbar spinal tuberculosis: clinical and radiological outcomes

The Use of Small-Molecule Compounds for Cell Adhesion and Migration in Regenerative Medicine

Current advancements in bio-ink technology for cartilage and bone tissue engineering

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