Small molecule sensors for the colorimetric detection of Copper(II): A review of the literature from 2010 to 2022

Trevino, Kimberly M.; Wagner, Caitlyn R.; Tamura, Eric K.; Garcia, Joel; Louie, Angelique Y.

doi:10.1016/j.dyepig.2022.110881

Cited by 22 publications

(3 citation statements)

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“…Emission spectral analysis showed that ligand (3) is a promising candidate for the detection of Cu 2+ ions in aqueous medium with limit of detection (LOD) of 60.3 nM. This detection limit with high selectivity is one of the lowest for Cu 2+ ions detection in aqueous medium [22–33] . The Schiff base ligand (3) is effective and better than many reported ones because of its ease synthesis, portability and cost effectiveness.…”

Section: Introductionmentioning

confidence: 98%

“…This detection limit with high selectivity is one of the lowest for Cu 2 + ions detection in aqueous medium. [22][23][24][25][26][27][28][29][30][31][32][33] The Schiff base ligand (3) is effective and better than many reported ones because of its ease synthesis, portability and cost effectiveness. The computed molecular orbital energy gap, molecular electrostatic potential (MEP) and various global quantities of DFT optimized sensor structure, also confirmed the sensing results.…”

Section: Introductionmentioning

confidence: 99%

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Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu²⁺ Ion in Irrigation Water by Schiff Base

2023

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Numerous chemosensors have been reported for the detection of heavy metal ions in drinking water or in biological system pertaining to health concerns. Here, in the present study we have focused on synthesis of simple, efficient chemosensors for one of such ion i. e. Cu2+ due to its prevalent importance. Chemosensor (3) has been synthesized from sulfanilamide and nitro‐benzaldehyde which was further characterized with various analyses such as 1H NMR, 13C NMR, FT‐IR and mass spectrometry. The absorbance and emission studies results showed that sensor (3) has profound sensitivity and selectivity for Cu2+ ions in aqueous medium by quenching the emission intensity of the same at 335 nm. Whereas the complexation of sensor (3) with Cu2+ ion produced the change in color from pale yellow to green, in semi aqueous medium with gradual addition of Cu2+. The sensor was also tested against various water samples and found to generate 100.4 % recovery from irrigation water sample. Further computational analyses were performed to verify the sensing mechanism and also different global quantities such as electron affinity (A), ionisation potential (I), electronegativity (χ), global softness (S), hardness (η), and electrophilicity (ψ) were calculated.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu²⁺ Ion in Irrigation Water by Schiff Base

2023

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“…explored the performance of different organic compounds, including Schiff bases, thiourea, pyridine, and rhodamine, as chemosensors specifically for Zn 2+ [16]. Trevino et al reviewed small-molecule Cu 2+ sensors that provide a color response visible to the naked eye in solutions [28]. Here, the focus was on the molecular structural features and sensing mechanisms in environmental and biological samples.…”

Section: Introductionmentioning

confidence: 99%

Strategies for Improving Selectivity and Sensitivity of Schiff Base Fluorescent Chemosensors for Toxic and Heavy Metals

Musikavanhu,

Liang,

Xue

et al. 2023

Molecules

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Toxic cations, including heavy metals, pose significant environmental and health risks, necessitating the development of reliable detection methods. This review investigates the techniques and approaches used to strengthen the sensitivity and selectivity of Schiff base fluorescent chemosensors designed specifically to detect toxic and heavy metal cations. The paper explores a range of strategies, including functional group variations, structural modifications, and the integration of nanomaterials or auxiliary receptors, to amplify the efficiency of these chemosensors. By improving selectivity towards targeted cations and achieving heightened sensitivity and detection limits, consequently, these strategies contribute to the advancement of accurate and efficient detection methods while increasing the range of end-use applications. The findings discussed in this review offer valuable insights into the potential of leveraging Schiff base fluorescent chemosensors for the accurate and reliable detection and monitoring of heavy metal cations in various fields, including environmental monitoring, biomedical research, and industrial safety.

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Dual Mode Ratiometric Analysis of Cu²⁺ and Ni²⁺ Ions at Physiological pH: Effect of Signalling Units on Analytical Efficacy

Dey,

Ray,

Bhattacharya

2024

Asian J Org Chem

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Herein, we report the metal ion sensing property of two 2,2’‐bis(pyridylmethyl) amine‐based chromogenic probes at physiological pH in buffered media. The binding of metal ions to the bispicolyl site alters its electronic property, which subsequently influences the optical property of the covalently‐linked signaling unit. The compound experienced a change in the solution color from red to deep and light yellow respectively upon the addition of Cu2+ and Ni2+ ions. Further, it is observed that by modifying the signaling unit, one can tune the mode of metal ion binding and sensitivity. The compound with an electron‐deficient quinolinium unit as the signaling moiety, showed 2:1 stoichiometry of binding with metal ions, while the compound functionalized with a pyrene unit formed complexes with 1:1 stoichiometry. It was conferred that changes in the signaling moiety not only alter the basicity/ nucleophilicity of the pyridine nitrogen ends but also influence their aggregation properties. Such kind of studies will be beneficial for engineering new optical probes with tuneable sensitivity.

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Small molecule sensors for the colorimetric detection of Copper(II): A review of the literature from 2010 to 2022

Cited by 22 publications

References 161 publications

Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu²⁺ Ion in Irrigation Water by Schiff Base

Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu²⁺ Ion in Irrigation Water by Schiff Base

Strategies for Improving Selectivity and Sensitivity of Schiff Base Fluorescent Chemosensors for Toxic and Heavy Metals

Dual Mode Ratiometric Analysis of Cu²⁺ and Ni²⁺ Ions at Physiological pH: Effect of Signalling Units on Analytical Efficacy

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Small molecule sensors for the colorimetric detection of Copper(II): A review of the literature from 2010 to 2022

Cited by 22 publications

References 161 publications

Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu2+ Ion in Irrigation Water by Schiff Base

Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu2+ Ion in Irrigation Water by Schiff Base

Strategies for Improving Selectivity and Sensitivity of Schiff Base Fluorescent Chemosensors for Toxic and Heavy Metals

Dual Mode Ratiometric Analysis of Cu2+ and Ni2+ Ions at Physiological pH: Effect of Signalling Units on Analytical Efficacy

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Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu²⁺ Ion in Irrigation Water by Schiff Base

Computational Studies and Fluorescent Turn‐off Sensing of Biologically Important Cu²⁺ Ion in Irrigation Water by Schiff Base

Dual Mode Ratiometric Analysis of Cu²⁺ and Ni²⁺ Ions at Physiological pH: Effect of Signalling Units on Analytical Efficacy