Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19

An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives

“…117 Some in silico studies also showed that several natural compounds may significantly bind with SARS-CoV-2 nucleocapsid protein. 118,119 In the process, top-ranked compounds are not yet tested in humans but docking a repurposing library, with billions of compounds, can result in the discovery of a useful deployable new antiviral compound on cells and in animals (Fig. 9).…”