Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia

Chandravanshi, Bhawna; Bhonde, Ramesh

doi:10.1016/j.ejphar.2016.09.012

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Despite this, exogenous miR-30a mimics can exert significant effects in most cases. Increased oxidative stress, apoptosis, and death may reduce the production and secretion of insulin in beta islet cells 25 . Therefore, the effects of miR-30a on insulin levels may be associated with its anti-inflammatory activities.…”

Section: Discussionmentioning

confidence: 99%

MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor

Jiang

Fan

et al. 2017

Sci Rep

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Diabetes is an inflammatory disease. Inflammation plays an important role in islet functions. However, the exact mechanisms by which inflammation affects islet functions remain unclear. In this study, we investigated the regulatory effects of miR-30a on inflammation and islet functions. The results indicate that miR-30a serves as an inflammation-resolving buffer factor by targeting interleukin 1a (IL-1α) in immune cells and in islet cells, which might play an important role in inflammation homeostasis. miR-30a ameliorates islet functions in an inflammatory micro-environment by targeting the IL-1α/nuclear factor kappa B (NFKB) p65 subunit (p65)/p62 (SQSTM1)/insulin axis, which can be developed into a novel antidiabetic approach. miR-30a serves as a promising inflammation-response biomarker in inflammatory diseases and is possibly activated by the toll-like receptor 4 (TLR4)/IL-1α/NFKB pathways. However, the exact molecular mechanisms by which miR-30a regulates inflammation and islet functions as well as the potential applications in transitional medicine require further elucidation.

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Section: Discussionmentioning

confidence: 99%

MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor

Jiang

Fan

et al. 2017

Sci Rep

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“… 89 In recent study, combinations of these molecules (EPA + DHA + GABA and EPA + DHA + Metformin) reduced ROS production induced by hypoxia (1% O 2 for 48 hours) in 3D islet like clusters derived from human umbilical cord of mesenchymal stem cells. 90 Another organic chemical, puerarin (a major isoflavonoid), alleviated β-cell apoptosis and malfunction by hypoxic injury of β-cells in obese mice induced by cobalt chloride induced via PI3K/Akt pathway activation. 91 Orally administered puerarin also activated the glucagon-like peptide1receptor pathway and subsequent Akt activation, leading to improved mouse β-cell survival.…”

Section: Oxygen Treatment Of Islets For Transplantationmentioning

confidence: 99%

Impact of Oxygen on Pancreatic Islet Survival

Komatsu

Kandeel²,

Mullen³

2018

Pancreas

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Pancreatic islet transplantation is a promising treatment option for individuals with type 1 diabetes; however, maintaining islet function after transplantation remains a large challenge. Multiple factors, including hypoxia associated events, trigger pretransplant and posttransplant loss of islet function. In fact, islets are easily damaged in hypoxic conditions before transplantation including the preparation steps of pancreas procurement, islet isolation, and culture. Furthermore, after transplantation, islets are also exposed to the hypoxic environment of the transplant site until they are vascularized and engrafted. Because islets are exposed to such drastic environmental changes, protective measures are important to maintain islet viability and function. Many studies have demonstrated that the prevention of hypoxia contributes to maintaining islet quality. In this review, we summarize the latest oxygen-related islet physiology, including computational simulation. Furthermore, we review recent advances in oxygen-associated treatment options used as part of the transplant process, including up-to-date oxygen generating biomaterials as well as a classical oxygen inhalation therapy.

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“…PDX-1 50 , 51 , inhibition of Notch signalling 52 and laminin 411 53 effectively regulate the differentiation of MSCs into IPCs. Under hypoxic conditions, UCB-MSCs also efficiently differentiate into IPCs 54 , 55 . Additionally, factors that effectively promote the efficacy of IPC action include Port-A catheter transplantation 56 , suspension culture 57 , and addition of the histone deacetylase (HDAC) inhibitor TMP269 58 .…”

Section: Possible Mechanisms Of Huc-mscs For Dm Treatmentmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications: applications and research advances

Li,

Guan

et al. 2023

Int. J. Med. Sci.

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Diabetes mellitus and its complications pose a major threat to global health and affect the quality of life and life expectancy of patients. Currently, the application of traditional therapeutic drugs for diabetes mellitus has great limitations and can only temporarily control blood glucose but not fundamentally cure it. Mesenchymal stem cells, as pluripotent stromal cells, have multidirectional differentiation potential, high self-renewal, immune regulation, and low immunogenicity, which provide a new idea and possible development direction for diabetes mellitus treatment. Regenerative medicine with mesenchymal stem cells treatment as the core treatment will become another treatment option for diabetes mellitus after traditional treatment. Recently, human umbilical cord mesenchymal stem cells have been widely used in basic and clinical research on diabetes mellitus and its complications because of their abundance, low ethical controversy, low risk of infection, and high proliferation and differentiation ability. This paper reviews the therapeutic role and mechanism of human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications and highlights the challenges faced by the clinical application of human umbilical cord mesenchymal stem cells to provide a more theoretical basis for the application of human umbilical cord mesenchymal stem cells in diabetes mellitus patients.

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Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia

Cited by 8 publications

References 28 publications

MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor

MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor

Impact of Oxygen on Pancreatic Islet Survival

Human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications: applications and research advances

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