2021
DOI: 10.21203/rs.3.rs-965128/v1
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Small Molecules Facilitate Single Factor-Mediated Sweat Gland Cell Reprogramming

Abstract: Background: Large skin defect caused severe disruption to the overall skin structure and irreversible damage of sweat gland (SG), resulting in destroy of physiological function of the skin. Reprogramming fibroblasts into sweat gland lineages may provide a promising strategy to obtain the desirable cell types for functional repair and regeneration of damaged skin. Methods: A direct reprogramming strategy of single factor ectodermal dysplasia antigen (EDA) in combination with small molecule cocktails promoting c… Show more

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