Small nonfunctional parathyroid cysts: single institution experience

Preradović, Ljubica Fuštar; Đanić, Davorin; Džodić, Radan

doi:10.1507/endocrj.ej16-0398

Cited by 13 publications

(13 citation statements)

References 21 publications

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“… 2 Ultrasonography is a sensitive but less specific method due to many variations in PC visualization in terms of PC shape, size, and location. 7 CT scan and MRI show nonspecific cystic lesion. 1 They can help establish the relationship to adjacent tissues particularly in the presence of compressive symptoms or substernal extension, and they are also indicated in mediastinal localizations of PCs.…”

Section: Discussionmentioning

confidence: 99%

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Parathyroid cyst: A rare entity

Châabouni

Achour

Thabet

et al. 2021

SAGE Open Medical Case Reports

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Parathyroid cysts are an uncommon entity. They are classified as functioning and nonfunctioning cysts. Cyst aspiration with detection of parathyroid hormone is a useful tool to confirm the diagnosis. Here, we report four cases of parathyroid cysts. One patient had a functioning cyst. Ultrasonography of the neck revealed a cystic lesion behind the left lobe of the thyroid gland in two cases and a right cystic thyroid nodule in two cases. The cysts exerted a mass effect on the adjacent structures in two cases without clinical compressive symptoms. Fine-needle aspiration with detection of parathyroid hormone in the cyst fluid was performed in one case (nonfunctioning cyst): intracystic parathyroid hormone level was high. Recurrence was noted 1 month after the cyst aspiration. All patients underwent surgical treatment. Our series is characterized by two cases of nonfunctioning intrathyroidal parathyroid cysts which are very uncommon. They are mistaken for thyroid cysts. After surgery, no recurrence was noted. We aim to describe the epidemiological, clinical, and paraclinical features of this condition as well as its therapeutic modalities.

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Section: Discussionmentioning

confidence: 99%

“… 6 , 10 , 11 The cytomorphological sample is mostly pauci- or acellular. 7 The cytological exam reveals small clusters of epithelial cells and fibroblasts. 1 PCs contain high concentrations of PTH.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid cyst: A rare entity

Châabouni

Achour

Thabet

et al. 2021

SAGE Open Medical Case Reports

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“…The majority of cases are asymptomatic, presenting with an incidentally found neck mass, which can be palpable and mimic a thyroid nodule. [ 13 , 25 , 32 , 77 – 94 ] Alvi et al [ 18 ] and Coates et al [ 95 ] reported that larger cysts can cause compressive symptoms and mediastinal ones can cause recurrent laryngeal nerve palsy. Compressive symptoms such as dysphagia, odynophagia, dyspnea, asthma, stridor, hoarseness, vein thrombosis, cough, vomiting, choking sensation are caused by displacement of the adjacent structures.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid cysts

Papavramidis

Chorti²,

Pliakos³

et al. 2018

Medicine

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Background:Parathyroid cysts are lesions that represent 1–5% of neck masses. They are subdivided into two categories: functioning and non-functioning.The aim of the present review is to give a detailed account of all reported cases of parathyroid cysts in the literature and to analyze statistically the available data.Methods:A bibliographic research was performed from 1905 until 2016. A database with the patients’ characteristics was made and analyzed statistically.Results:A total of 218 articles were found, reporting 359 cases of cysts. Mean age of patients was 49.24 y/o and the male/female ratio was 1:1.85. The most common locations were left thyroid lobe (113/358 patients, 31.6%), and superior mediastinum (69/358 patients, 19.3%), while the most common symptoms were neck mass (148/355 patients, 41.7%), compressive symptoms (73/355 patients, 206%) and hyperparathyroidism (62/355 patients, 17.5%). Non-functioning cysts were more frequent (220/357 patients, 61.6%). Regarding dimensions, mean diameter was 4.88 cm. Ultrasound and FNA are used for their diagnosis, while cystic fluid analysis may help the differential diagnosis. Recurrences were mentioned in 27/97 patients (27.8%) with available data. No deaths due to parathyroid cysts were mentioned in the literature.Conclusion:Parathyroid cysts should be taken into consideration in case of parathyroid dysfunction or asymptomatic neck mass. The surgeon's careful manipulations on the cyst are crucial for a definitive treatment.

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“…Sclerosing agent injections are not recommended because they can flow out from the capsule and cause serious complications such as fiber degeneration or damage to the recurrent laryngeal nerve, resulting in vocal cord paralysis [ 26 , 27 ]. It has been suggested that the optimal treatment for symptomatic NFPCs is surgical resection [ 1 , 28 ]. In the present report, 5 patients with NFPC (diameter greater than 2.5 cm) underwent cyst resection alone.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid cysts: experience of a rare phenomenon at a single institution

Xia

et al. 2018

BMC Surg

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BackgroundParathyroid cysts are relatively uncommon lesions and are often misdiagnosed. We evaluate our experience in the diagnosis of and therapy to correct parathyroid cystic lesions.MethodsWe retrospectively reviewed a series of 32 patients with parathyroid cysts who were admitted to our department between July 2011 and November 2016. Clinical pathological features of the patients, including age, gender, location, size, ultrasonography, histopathology, surgery, and follow-up, were analyzed.ResultsThere were 22 female and 10 male participants with a median age of 46.7 years old (27–76 years old). Only two cysts were found in the superior mediastinum. The rest were located under the lower pole of the thyroid. All of the patients underwent ultrasonography scans and serum parathyroid hormone (PTH) assays. Three patients had elevated serum PTH levels, and they were further scanned with Tc99m sestamibi as functional cysts. In 29 cases of nonfunctional cysts, 3 cases were preoperatively diagnosed by cystic aspiration with PTH detection. The rest were diagnosed by postoperative immunopathology. All of the patients underwent cystectomy, and 24 patients also underwent thyroidectomy. There was a significant difference in cyst diameter size between the cystectomy alone and cystectomy with thyroidectomy groups (4.0 ± 2.0 vs 1.5 ± 1.0 cm; p < 0.05). No participant experienced recurrence during the median 36 months of follow-up.ConclusionsCystic lesions located under the lower pole of the thyroid gland should be considered to have originated at the parathyroid gland. Cystic aspiration with PTH detection or postoperative immunopathology can lead to a definitive diagnosis. Cystectomy is still a commonly used and effective treatment.

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Small nonfunctional parathyroid cysts: single institution experience

Cited by 13 publications

References 21 publications

Parathyroid cyst: A rare entity

Parathyroid cyst: A rare entity

Parathyroid cysts

Parathyroid cysts: experience of a rare phenomenon at a single institution

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