Small Nucleolar RNA Host Genes and Long Non-Coding RNA Responses in Directly Irradiated and Bystander Cells

Chaudhry, M. Ahmad

doi:10.1089/cbr.2013.1574

Cited by 20 publications

(16 citation statements)

References 49 publications

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“…There were studies demonstrating that LncRNAs have several important biological functions such as cell cycle regulation, chromatin modification and nuclear-cytoplasmic tracking [51-53]. Radiation was reported to induce significant up-regulation or down-regulation of LncRNAs [54-57]. However, whether LncRNA regulated WISP1 expression and was involved in cell radioresponse has been less studied.…”

Section: Discussionmentioning

confidence: 99%

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

Zhang

Luo

et al. 2015

Oncotarget

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Radiotherapy is a primary treatment modality for esophageal squamous cell carcinoma (ESCC). However, most of patients benefited little from radiotherapy due to refractory radioresistance. We found that WISP1, a downstream target gene of Wnt/β-catenin pathway, was re-expressed in 67.3 % of ESCC patients as an oncofetal gene. Expression of WISP1 predicted prognosis of ESCC patients treated with radiotherapy. Overall survival in WISP1-positive patients was significantly poorer than in WISP1-negative patients. Serum concentration of WISP1 after radiotherapy reversely correlated with relapse-free survival. Gain and loss of function studies confirmed that WISP1 mediated radioresistance both in esophageal squamous cancer cells and in xenograft tumor models. Further studies revealed that WISP1 contributed to radioresistance primarily by repressing irradiation-induced DNA damage and activating PI3K kinase. LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance. Furthermore, WISP1 facilitated its own expression in response to radiation, creating a positive feedback loop and increased radioresistance. Our study revealed WISP1 as a potential target to overcome radioresistance in ESCC.

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Section: Discussionmentioning

confidence: 99%

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

Zhang

Luo

et al. 2015

Oncotarget

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“…Long non-coding RNA SNHG7 (lncRNA-SNHG7), which is 2176 bp-long and located on chromosome 9q34.3, is a recognized bidirectional lncRNA. It was reported that it could guide snoRNA to undergo posttranslational modification (13). Furthermore, it was a ribosomal RNA involved in modifying the growth and proliferation of cells.…”

Section: Introductionmentioning

confidence: 99%

High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma

Shen

et al. 2020

Oncol Lett

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Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportional models were used to study the impact on clinical outcome. Expression of lncRNA-SNHG7 was much higher in cancer tissues than that in para-cancer tissues. The lncRNA-SNHG7 expression was correlated with tumor number, lymph node metastasis and clinical stage (P<0.05). In addition, HCC patients with higher lncRNA-SNHG7 expression had significantly poorer progression-free survival time and overall survival time (P<0.001). Both univariate analysis and multivariate analysis indicated that high expression of lncRNA-SNHG7 was an independent predictor of poor prognosis in HCC. LncRNA-SNHG7 might contribute to the development of HCC and serve as a clinical biomarker and a therapeutic target for HCC patients.

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“…Hypoxia has been shown to regulate DNA methylation , histone demethylases , and noncoding RNAs . The most widely studied epigenetic modification is methylation at the 5′‐position of a cytosine in a cytosine–phosphate–guanosine (CpG) dinucleotide.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-Mediated Epigenetic Regulation of Stemness in Brain Tumor Cells

et al. 2017

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Activation of pluripotency regulatory circuit is an important event in solid tumor progression and the hypoxic microenvironment is known to enhance the stemness feature of some cells. The distinct population of cancer stem cells (CSCs)/tumor initiating cells exist in a niche and augment invasion, metastasis, and drug resistance. Previously, studies have reported global hypomethylation and site-specific aberrant methylation in gliomas along with other epigenetic modifications as important contributors to genomic instability during glioma progression. Here, we have demonstrated the role of hypoxia-mediated epigenetic modifications in regulating expression of core pluripotency factors, OCT4 and NANOG, in glioma cells. We observe hypoxia-mediated induction of demethylases, ten-eleven-translocation (TET) 1 and 3, but not TET2 in our cell-line model. Immunoprecipitation studies reveal active demethylation and direct binding of TET1 and 3 at the Oct4 and Nanog regulatory regions. Tet1 and 3 silencing assays further confirmed induction of the pluripotency pathway involving Oct4, Nanog, and Stat3, by these paralogues, although with varying degrees. Knockdown of Tet1 and Tet3 inhibited the formation of neurospheres in hypoxic conditions. We observed independent roles of TET1 and TET3 in differentially regulating pluripotency and differentiation associated genes in hypoxia. Overall, this study demonstrates an active demethylation in hypoxia by TET1 and 3 as a mechanism of Oct4 and Nanog overexpression thus contributing to the formation of CSCs in gliomas. Stem Cells 2017;35:1468-1478.

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Small Nucleolar RNA Host Genes and Long Non-Coding RNA Responses in Directly Irradiated and Bystander Cells

Cited by 20 publications

References 49 publications

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma

Hypoxia-Mediated Epigenetic Regulation of Stemness in Brain Tumor Cells

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