2024
DOI: 10.3390/cimb46060324
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Small Peptide Derived from SFRP5 Suppresses Melanogenesis by Inhibiting Wnt Activity

Yoon-Seo Choi,
Jin-Gwen Hong,
Dong-Young Lim
et al.

Abstract: Melanocytes, located in the epidermis’ basal layer, are responsible for melanin pigment production, crucial for skin coloration and protection against UV radiation-induced damage. Melanin synthesis is intricately regulated by various factors, including the Wnt signaling pathway, particularly mediated by the microphthalmia-associated transcription factor (MITF). While MITF is recognized as a key regulator of pigmentation, its regulation by the Wnt pathway remains poorly understood. This study investigates the r… Show more

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