Small RNA-seq and hormones in the testes of dwarf hamsters (Cricetulus barabensis) reveal the potential pathways in photoperiod regulated reproduction

Wang, Shuo; Xu, Jinhui; Zhao, Xiangyu; Feng, Yong-Zhen; Xu, Wenlei; Xue, Hang; Wu, Ming; Xu, Laixiang

doi:10.1016/j.heliyon.2023.e15687

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e15687

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Small RNA-seq and hormones in the testes of dwarf hamsters (Cricetulus barabensis) reveal the potential pathways in photoperiod regulated reproduction

Shuo Wang¹,

Jinhui Xu²,

Xiangyu Zhao³

et al.

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Cited by 2 publications

References 37 publications

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Photoperiod affects oxidative stress in the liver of Cricetulus barabensis through the Nrf2-Keap1 signaling pathway

Wang,

Wang

et al. 2023

Biological Rhythm Research

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Photoperiod affects oxidative stress in the liver of Cricetulus barabensis through the Nrf2-Keap1 signaling pathway

Wang,

Wang

et al. 2023

Biological Rhythm Research

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cba‐miR‐222‐3p involved in photoperiod‐induced apoptosis in testes of striped hamsters by targeting TRAF7

WANG,

XU,

WANG

et al. 2024

Integr. Zool.

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The role of miRNAs in the regulation of seasonal reproduction in rodents, particularly in relation to photoperiod changes, is still poorly understood. Previous studies on miRNA transcriptomes of striped hamster (Cricetulus barabensis) testes have indicated that the photoperiodism of testes, especially apoptosis, may be influenced by miRNAs. As a functional miRNA, cba‐miR‐222‐3p in striped hamster testes exhibits suppression under a short photoperiod. To elucidate the potential role of testicular cba‐miR‐222‐3p in the seasonal reproduction of striped hamsters, we exposed male striped hamsters to different photoperiods or injected miRNA agomir into the testes and observed the effects of these treatments, particularly some indicators related to apoptosis. The results showed that the levels of apoptosis in the testes increased in short daylength, accompanied by a significant decrease in cba‐miR‐222‐3p expression and an increase in TRAF7 expression. Dual luciferase reporter assays verified the targeting relationship between cba‐miR‐222‐3p and TRAF7 predicted by bioinformatics. In addition, the expression of TRAF7 decreased in the testes, which injected miRNA agomir, leading to inhibition of apoptosis, and the expression of key genes (MEKK3, p38, p53) in the downstream MAPK signaling pathway of TRAF7 was suppressed. These results suggest that short daylength induces testicular apoptosis in striped hamsters, and one possible mechanism is that the decreased expression of miR‐222‐3p in testes reduces the repression of TRAF7 translation, thereby activating the MAPK pathway and affecting the level of testicular apoptosis. These findings reveal the potential role of miR‐222‐3p in animal reproduction and provide new insights into the regulation of rodent populations.

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Small RNA-seq and hormones in the testes of dwarf hamsters (Cricetulus barabensis) reveal the potential pathways in photoperiod regulated reproduction

Cited by 2 publications

References 37 publications

Photoperiod affects oxidative stress in the liver of Cricetulus barabensis through the Nrf2-Keap1 signaling pathway

Photoperiod affects oxidative stress in the liver of Cricetulus barabensis through the Nrf2-Keap1 signaling pathway

cba‐miR‐222‐3p involved in photoperiod‐induced apoptosis in testes of striped hamsters by targeting TRAF7

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