Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells

Wang, Zhanhuai; Tan, Yinuo; Yu, Wei; Zheng, Shu; Zhang, Suzhan; Sun, Long; Ding, Kefeng

doi:10.7150/ijbs.17680

Cited by 31 publications

(24 citation statements)

References 73 publications

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“…MicroRNAs (miRNAs) are endogenous noncoding RNAs with 19-22 nucleotides in length that modulate variety of ceEllular processes in a post-transcriptional manner, which emerging as novel epigenetic regulators during gene expression 9 . MiRNAs are also associated with regulation of cell growth, division, apoptosis, and other physiological or pathological cellular processes within almost all cells to regulate different diseases 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

MiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3

Chu¹,

Liu²,

Bai³

et al. 2018

Int. J. Biol. Sci.

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Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased in both human BC tissues and MCF-7 cells. CCK8 and 5-Ethynyl-2′-deoxyuridine (EdU) assays were used to evaluate cell proliferation. Wound-healing and transwell assays were performed for detection of cell migration and invasion. The results demonstrated miR-519d overexpression dramatically suppressed MCF-7 cells proliferation, migration and invasion. While downregulation of miR-519d by miR-519d inhibitor substantially increased MCF-7 cell carcinogenesis. Further analysis identified Matrix Metalloproteinase-3 (MMP3) as a direct target of miR-519d. QRT-PCR and western blot results indicated the correlative expression of miR-519d and MMP3 in BC tissues and MCF-7 cells. In summary, our data uncovered the novel molecular interaction between miR-519d and MMP3, indicating a therapeutic strategy of miR-519d for BC.

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Section: Introductionmentioning

confidence: 99%

MiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3

Chu¹,

Liu²,

Bai³

et al. 2018

Int. J. Biol. Sci.

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“…MicroRNAs (miRNAs) are one of the main classes of non-coding RNAs 10 . These are small non-coding RNAs that regulate expression of genes in cells 11 . The human genome encodes thousands of miRNAs 12 .…”

Section: Introductionmentioning

confidence: 99%

miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)

Hussein

Akula

2017

Sci Rep

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Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry. We recently demonstrated that KSHV induces a plethora of host cell miRNAs during the early stages of infection. In this study, we show the ability of host cell novel miR-36 to specifically inhibit KSHV-induced expression of interferon induced transmembrane protein 1 (IFITM1) to limit virus infection of cells. Transfecting cells with miR-36 mimic specifically lowered IFITM1 expression and thereby significantly dampening KSHV infection. In contrast, inhibition of miR-36 using miR-36 inhibitor had the direct opposite effect on KSHV infection of cells, allowing enhanced viral infection of cells. The effect of miR-36 on KSHV infection of cells was at a post-binding stage of virus entry. The highlight of this work was in deciphering a common theme in the ability of miR-36 to regulate infection of closely related DNA viruses: KSHV, Epstein-Barr virus (EBV), and herpes simplexvirus-2 (HSV-2). Taken together, we report for the first time the ability of host cell miRNA to regulate internalization of KSHV, EBV, and HSV-2 in hematopoietic and endothelial cells.

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“…The ANXA6/LRP1/TSP1 complex causes tumor growth induction. miR-126 and miR-146a are involved in tumor suppression [27][28][29][30]. Moreover, exosomes, with a structure rich in lipids, especially cholesterol and sphingomyelin, can modulate the lipid composition of the target cells, disturbing their homeostasis.…”

Section: Tumor Progressionmentioning

confidence: 99%

Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy

Lorenc

Klimczyk

Michalczewska

et al. 2020

IJMS

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Prostate cancer (PCa) is the second most common cause of cancer-related mortality among men in the developed world. Conventional anti-PCa therapies are not effective for patients with advanced and/or metastatic disease. In most cases, cancer therapies fail due to an incomplete depletion of tumor cells, resulting in tumor relapse. Exosomes are involved in tumor progression, promoting the angiogenesis and migration of tumor cells during metastasis. These structures contribute to the dissemination of pathogenic agents through interaction with recipient cells. Exosomes may deliver molecules that are able to induce the transdifferentiation process, known as "epithelial to mesenchymal transition". The composition of exosomes and the associated possibilities of interacting with cells make exosomes multifaceted regulators of cancer development. Extracellular vesicles have biophysical properties, such as stability, biocompatibility, permeability, low toxicity and low immunogenicity, which are key for the successful development of an innovative drug delivery system. They have an enhanced circulation stability and bio-barrier permeation ability, and they can therefore be used as effective chemotherapeutic carriers to improve the regulation of target tissues and organs. Exosomes have the capacity to deliver different types of cargo and to target specific cells. Chemotherapeutics, natural products and RNA have been encapsulated for the treatment of prostate cancers.

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Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells

Cited by 31 publications

References 73 publications

MiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3

MiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3

miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)

Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy

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