Small scale trial of photodynamic treatment of onychomycosis in São Paulo

Tardivo, João Paulo; Wainwright, Mark; Baptista, Maurı́cio S.

doi:10.1016/j.jphotobiol.2015.03.015

Cited by 38 publications

(24 citation statements)

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“…The use of MB and TBO in the photodynamic treatment of onychomycosis was recently reported. Local application of PS (MB and TBO) and illumination of infected nails produced a response in 53 out of 62 patients, without any collateral effect, and 28 patients showed complete clearance [56].…”

Section: Discussionmentioning

confidence: 96%

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

et al. 2018

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In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers http://researchonline.ljmu.ac.uk/7434/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription.

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Section: Discussionmentioning

confidence: 96%

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

et al. 2018

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“…Such broad-spectrum potential is important given the polymicrobial nature of many clinical infections and would aid in local 'photoempirical' administration for wounds at the clinical triage stage, this being a logical application of photoantimicrobials, allowing conservation of conventional systemic drugs. The efficacy of TBO against bacteria in biofilms [17] and in trialling against suitable conditions/presentations in vivo, such as onychomycosis [18] and osteomyelitis [19] is also encouraging, both for clinical involvement outside dentistry and in the search for improved photoantimicrobial agents.…”

Section: Antimicrobial Efficacymentioning

confidence: 99%

Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials

Wainwright

O'Kane

Rawthore

2016

Journal of Photochemistry and Photobiology B: Biology

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The phenothiazinium derivative toluidine blue O (TBO) is widely employed as a photoantimicrobial agent in clinical trialling, particularly in dentistry. However, its activity against a range of pathogenic microbial species is not significantly different to that of the standard photoantimicrobial methylene blue. In the current study, derivatives of TBO with varying hydrocarbon substitution in chromophore position 2 were synthesised via the established anilinethiosulphonic route, using the mild oxidant silver(II) carbonate to allow substituent preservation.The resulting series of analogues demonstrated the expected increases in visible absorption wavelength and lipophilicity with increasing hydrocarbon content, as well as decreased aggregation for derivatives with bulkier substituents, and all produced singlet oxygen on illumination in vitro. Screening against a range of bacterial and fungal pathogens relevant to infection control showed remarkable increases in activity relative to the parent compound, particularly against the clinically important Gram-negative bacterium Pseudomonas aeruginosa. In addition, in order to demonstrate clinical relevance, the photoactivities of the new derivatives against microbial targets were compared to conventional antibacterial and antifungal drugs, as well as biocides commonly used for local disinfection. Activity here was also generally greater than that of the conventional agents used for comparison, considerably so relative to the local disinfectant agents.

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“…Większość badań opublikowanych do tej pory to głównie opisy przypadków zastosowania PDT w leczeniu grzybicy paznokci Dermatology Review/Przegląd Dermatologiczny 2017/3 well tolerated by the patients, however they also reported adverse effects including mild pain, burning sensation, swelling and blisters. These adverse effects associated with PDT were well tolerated, required no additional treatment and resolved spontaneously [25].…”

Section: Omówieniementioning

confidence: 91%

“…W omówionych powyżej pracach autorzy wskazują, że pacjenci dobrze tolerowali PDT, jednak zgła-szali również działania niepożądane, takie jak łagodny ból, pieczenie, obrzęki, pęcherze. Wymienione skutki uboczne były dobrze tolerowane, nie wymagały dodatkowego leczenia i ustępowały samoistnie [25].…”

Section: Conflict Of Interestunclassified

Photodynamic therapy in the treatment of onychomycosis – a review

Kalinowska¹,

Hryncewicz-Gwóźdź²

2017

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Toenail onychomycosis is a common infection, affecting up to 14% of the population. Moreover, poor penetration of topical drugs into the nail bed leads to frequent recurrences of the disease. The cure rate of toenail onychomycosis is estimated at 63-76%. An alternative treatment for onychomycosis is photodynamic therapy. Following agents are used in this method: porfimer sodium, rose bengal, methylene blue, 5-aminolevulinic acid and its derivative -methyl ester. The therapy is well tolerated Photodynamic therapy offers an opportunity to achieve a significant cure rate in patients who cannot receive oral therapy. Thanks to systematic improvements in photodynamic therapy, including better photosensitizer penetration into the nail bed and shorter exposure time, photodynamic therapy may be more efficient and cost-effective than other onychomycosis treatments. However, randomized clinical trials evaluating the efficacy of photodynamic therapy of onychomycosis are needed. STRESZCZENIEGrzybica paznokci stóp jest częstym zakażeniem, może dotyczyć do 14% populacji. Ponadto utrudnione przenikanie substancji leczniczych do łożyska paznokcia w leczeniu miejscowym powoduje częste nawroty schorzenia. Szacuje się, że odsetek wyleczeń grzybicy paznokci stóp wynosi 63-76%. Terapia fotodynamiczna stanowi alternatywną metodę leczenia grzybicy paznokci. W tym zabiegu wykorzystuje się następu-jące substancje: porfimer sodu, róż bengalski, błękit metylenowy, kwas 5-aminolewulinowy oraz jego pochodną -ester metylowy. Leczenie jest dobrze tolerowane przez pacjentów. Dzięki zastosowaniu terapii fotodynamicznej można uzyskać znaczny odsetek wyleczeń wśród pacjentów, którzy nie mogą przyjmować terapii doustnej. Dzięki systematycznemu ulepszaniu terapii fotodynamicznej związanemu z lepszą penetracją fotouczulacza do łożyska paznokcia czy też ze skróceniem czasu naświetlania może być ona bardziej wydajna i kosztować mniej w porównaniu z innymi metodami leczenia onychomykozy. Konieczne są jednak randomizowane badania kliniczne oceniające skuteczność leczenia grzybicy paznokci za pomocą terapii fotodynamicznej.

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Small scale trial of photodynamic treatment of onychomycosis in São Paulo

Cited by 38 publications

References 10 publications

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials

Photodynamic therapy in the treatment of onychomycosis – a review

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