Small Titanium-Based MOFs Prepared with the Introduction of Tetraethyl Orthosilicate and Their Potential for Use in Drug Delivery

Abstract

Metal-organic frameworks (MOFs) have attracted much attention in the areas of biomedicine and medicine owing to their versatile porous structure. However, the oversize and high cellular toxicity of some metal-based MOF particles have hindered their development. Therefore, a series of small Ti-based MOFs are prepared with the introduction of tetraethyl orthosilicate (TEOS) into the reaction system. Compared with the Ti-based MOFs prepared by traditional methods, the size of the Ti-based MOFs prepared with this method is decreased by 42.78%. Meanwhile, the good biocompatibility of the prepared Ti-based MOF particles toward the L929 cell lines is proven using CCK-8 assays. Furthermore, the controlled release property of the Ti-based MOFs is evaluated by using ibuprofen (IBU) as a model drug. The amount of drug loaded in the samples is shown to be approximately 10%, and approximately 95% of the IBU is released from the MOFs after exposure to PBS for 24 h. We conclude that the size-decreased Ti-based MOFs prepared with the introduction of TEOS into the reaction systems are potential drug carriers in terms of their good biocompatibility and effective performance in the controlled release of a drug.

Synthesis and Functionalization of Porous Zr-Diaminostilbenedicarboxylate Metal–Organic Framework for Storage and Stable Delivery of Ibuprofen

“…Tailoring of the pore size (with tetraethyl orthosilicate-modified MIL-125-NH 2 ) has been demonstrated to be highly effective for drug delivery, especially in the case of IBU release. 40 Moreover, on the basis of the surface area, TC-Zr-DASDCA also showed increased adsorption or loading of IBU compared with pristine Zr-DASDCA (Figure 3b). The competitive loading of IBU onto TC-Zr-DASDCA might also be explained by reduced pore size.…”

Pd Supported IRMOF-3: Heterogeneous, Efficient and Reusable Catalyst for Heck Reaction

“…Recently metal-organic frameworks (MOFs), porous materials of a crystalline structure comprising bridged organic ligands and metal centers, have been attracted significant attention in gas sorption average owing to their large pore volumes and surface areas. Several studies have been 1 3 reported on MOFs utilization as heterogeneous catalysts [1][2][3][4], in gas storage [5], separation [6], drug delivery [7], and sensing [8,9]. These materials have been explored because of their intrinsic high surface area, tunable pores, and various functionalities [10].…”

Copper metal‐organic framework toward flame‐retardant enhancement of thermoplastic polyurethane elastomer composites based on ammonium polyphosphate

“…Metal‐organic frameworks (MOFs) are a new type of organic‐inorganic hybrid materials and have been attracted much attention 25‐28 . In recent years, MOFs had been explored as a novel flame retardant for polymers.…”