Small ubiquitin‐like modifier 2 (SUMO2) is critical for memory processes in mice

Abstract

Small ubiquitin-like modifier (SUMO1-3) conjugation (SUMOylation), a posttranslational modification, modulates almost all major cellular processes. Mounting evidence indicates that SUMOylation plays a crucial role in maintaining and regulating neural function, and importantly its dysfunction is implicated in cognitive impairment in humans. We have previously shown that simultaneously silencing SUMO1-3 expression in neurons negatively affects cognitive function. However, the roles of the individual SUMOs in modulating cognition and the mechanisms that link SUMOylation to cognitive processes remain unknown. To address these questions, in this study, we have focused on SUMO2 and generated a new conditional Sumo2 knockout mouse line. We found that conditional deletion of Sumo2 predominantly in forebrain neurons resulted in marked impairments in various cognitive tests,

Proteomic Identification of an Endogenous Synaptic SUMOylome in the Developing Rat Brain

“…The overall SUMO system is essential for the proper development and function of the brain. Indeed, disruption of the SUMOylation/deSUMOylation balance in animal models leads to deleterious effects such as neurodegeneration, seizure, impairments in learning and memory and/or dysfunctional behaviors ( Henley et al, 2018 ; Huang et al, 2020 ; Yu et al, 2020 ). In the context of hypothermia, hibernation or ischemia, SUMOylation levels are significantly increased as part of a physiological neuroprotective response to stressful events.…”

Botanical Drug Puerarin Ameliorates Liposaccharide‐Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

“…For SUMO transferase activity, puerarin upregulated the isoform Sumo2. Sumo2 is directly involved in the protein sumoylation for controlling the cognitive process in mice [ 45 ]. For the activation of protein kinase activity, puerarin upregulated insulin receptor (Insr) and calcium/calmodulin-dependent protein kinase kinase 2 (Camkk2).…”

SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth

“…In the cardiovascular system, SUMO2 activates calcium-regulated neurophosphatase NFAT signaling, which leads to myocardial inflammation and cardiac hypertrophy (36). SUMO2 is critical for cognitive processes, and knocking out the SUMO2 gene in mice leads to deficits in the memory process (37). A variety of proteins in the nervous system are SUMOylated (20).…”