Smart and emerging nanomaterials-based biosensor for SARS-CoV-2 detection

Singh, Kshitij RB; Rathee, Shweta; Nagpure, Gunjan; Singh, Jay; Singh, Ravindra Pratap

doi:10.1016/j.matlet.2021.131092

Cited by 32 publications

(31 citation statements)

References 35 publications

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“…Detection of COVID-19 is carried out through biomarkers by targeting biological markers without affecting the body. Structural proteins including spike (S) and nucleocapsid (N) are used as biomarkers in detection [ 74 ].…”

Section: Methods Of Detectionmentioning

confidence: 99%

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

et al. 2022

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Development and deployment of biosensors for the rapid detection of the 2019 novel severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are of utmost importance and urgency during this recent outbreak of coronavirus pneumonia (COVID-19) caused by SARS-CoV-2 infection, which spread rapidly around the world. Cases now confirmed in February 2022 indicate that more than 170 countries worldwide are affected. Recent evidence indicates over 430 million confirmed cases with over 5.92 million deaths scattered across the globe, with the United States having more than 78 million confirmed cases and over 920,000 deaths. The US now has many more cases than in China where coronavirus cases were first reported in late December 2019. During the initial outbreak in China, many leaders did not anticipate it could reach the whole world, spreading to many countries and posing severe threats to global health. The objective of this review is to summarize the origin of COVID-19, its biological nature, comparison with other coronaviruses, symptoms, prevention, treatment, potential, available methods for SARS-CoV-2 detection, and post-COVID-19 symptoms.

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Section: Methods Of Detectionmentioning

confidence: 99%

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

et al. 2022

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“…Nanomaterials, namely carbon-based, polymer-based, quantum-dot, and metal-based nanomaterials, are frequently intended for biosensing applications to diagnose SARS-CoV-2 infection through various modes of detection ( Table 1 )—such as viral sequence, antibody, or antigen, as illustrated in Figure 3 —as they have already exhibited their potential for detecting other viruses. Thus, nanomaterials and their composites have unique properties such as excellent adsorption, quantum-size effects, and great surface-to-volume ratios, which play a vital role in refining the performance of biosensors [ 53 ].…”

Section: Nanobiosensors For Sars-cov-2 Diagnosismentioning

confidence: 99%

State-of-the-Art Smart and Intelligent Nanobiosensors for SARS-CoV-2 Diagnosis

et al. 2022

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The novel coronavirus appeared to be a milder infection initially, but the unexpected outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly called COVID-19, was transmitted all over the world in late 2019 and caused a pandemic. Human health has been disastrously affected by SARS-CoV-2, which is still evolving and causing more serious concerns, leading to the innumerable loss of lives. Thus, this review provides an outline of SARS-CoV-2, of the traditional tools to diagnose SARS-CoV-2, and of the role of emerging nanomaterials with unique properties for fabricating biosensor devices to diagnose SARS-CoV-2. Smart and intelligent nanomaterial-enabled biosensors (nanobiosensors) have already proven their utility for the diagnosis of several viral infections, as various detection strategies based on nanobiosensor devices are already present, and several other methods are also being investigated by researchers for the determination of SARS-CoV-2 disease; however, considerably more is undetermined and yet to be explored. Hence, this review highlights the utility of various nanobiosensor devices for SARS-CoV-2 determination. Further, it also emphasizes the future outlook of nanobiosensing technologies for SARS-CoV-2 diagnosis.

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“… 1 , 2 , 3 , 4 Nanotechnology‐based strategies can be deployed for designing and developing innovative antivirals delivery systems, nanovaccines and (nano)biosensors. 5 , 6 Indeed, nanomaterials and nanoarchitectures with unique physicochemical properties can assist in the development of diagnostic tools with sensitivity/selectivity, simplicity and scalability for expeditious and economical detection of SARS‐CoV‐2. 7 , 8 , 9 On the other hand, smart antivirals delivery systems using various nanomaterials can assist in reducing the side effects and improve targeting/selectivity features.…”

Section: Introductionmentioning

confidence: 99%

“…Various therapeutic strategies and interventions are being advanced to identify an effective drug for COVID‐19 (coronavirus disease 2019) therapy, this disease being instigated by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) 1‐4 . Nanotechnology‐based strategies can be deployed for designing and developing innovative antivirals delivery systems, nanovaccines and (nano)biosensors 5,6 . Indeed, nanomaterials and nanoarchitectures with unique physicochemical properties can assist in the development of diagnostic tools with sensitivity/selectivity, simplicity and scalability for expeditious and economical detection of SARS‐CoV‐2 7‐9 .…”

Section: Introductionmentioning

confidence: 99%

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

Rabiee

Ahmadi

Soufi

et al. 2022

J of Chemical Tech & Biotech

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The application of quantum dots (QDs) for detecting and treating various types of coronaviruses is very promising, as their low toxicity and high surface performance make them superior among other nanomaterials; in conjugation with fluorescent probes they are promising semiconductor nanomaterials for the detection of various cellular processes and viral infections. In view of the successful results for inhibiting SARS‐CoV‐2, functional QDs could serve eminent role in the growth of safe nanotherapy for the cure of viral infections in the near future; their large surface areas help bind numerous molecules post‐synthetically. Functionalized QDs with high functionality, targeted selectivity, stability and less cytotoxicity can be employed for highly sensitive co‐delivery and imaging/diagnosis. Besides, due to the importance of safety and toxicity issues, QDs prepared from plant sources (e.g. curcumin) are much more attractive, as they provide good biocompatibility and low toxicity. In this review, the recent developments pertaining to the diagnostic and inhibitory potentials of QDs against SARS‐CoV‐2 are deliberated including important challenges and future outlooks. © 2022 Society of Chemical Industry (SCI).

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Smart and emerging nanomaterials-based biosensor for SARS-CoV-2 detection

Abstract: Graphical abstract

Cited by 32 publications

References 35 publications

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time

State-of-the-Art Smart and Intelligent Nanobiosensors for SARS-CoV-2 Diagnosis

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

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