Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release

Parisi, Ortensia Ilaria; Ruffo, Mariarosa; Scrivano, Luca; Malivindi, Rocco; Vassallo, Antonio; Puoci, Francesco

doi:10.3390/ph11040092

Cited by 22 publications

(9 citation statements)

References 22 publications

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“…MIPs have already been used as selective oral adsorbents for cholesterol [ 19 ] and imprinted bile acid sequestrants [ 20 , 21 ]. Commonly, MIPs are widely used as DDS in various diseases such as cancer [ 22 ], arrhythmia [ 23 , 24 ], avitaminosis [ 25 ], cardiovascular and cerebrovascular disease [ 26 ], inflammation [ 27 ], addictive disease [ 28 , 29 ] and other [ 30 ]. There are also several applications in which MIPs are incorporated into membranes to be used for bio-separation and bio-purification [ 31 ].…”

Section: Fundamentals Of Mipsmentioning

confidence: 99%

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Lusina

Cegłowski

2022

Polymers

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Molecularly Imprinted Polymers (MIPs) are polymeric networks capable of recognizing determined analytes. Among other methods, non-covalent imprinting has become the most popular synthesis strategy for Molecular Imprinting Technology (MIT). While MIPs are widely used in various scientific fields, one of their most challenging applications lies within pharmaceutical chemistry, namely in therapeutics or various medical therapies. Many studies focus on using hydrogel MIPs in transdermal drug delivery, as the most valuable feature of hydrogels in their application in drug delivery systems that allow controlled diffusion and amplification of the microscopic events. Hydrogels have many advantages over other imprinting materials, such as milder synthesis conditions at lower temperatures or the increase in the availability of biological templates like DNA, protein, and nucleic acid. Moreover, one of the most desirable controlled drug delivery applications is the development of stimuli-responsive hydrogels that can modulate the release in response to changes in pH, temperature, ionic strength, or others. The most important feature of these systems is that they can be designed to operate within a particular human body area due to the possibility of adapting to well-known environmental conditions. Therefore, molecularly imprinted hydrogels play an important role in the development of modern drug delivery systems.

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Section: Fundamentals Of Mipsmentioning

confidence: 99%

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Lusina

Cegłowski

2022

Polymers

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“…The molar ratio of the functional monomer to template directly affects the amount of binding sites available in the final polymer product . Hence, different molar concentrations of the ANI and MA (10:1, 10:2, 10:3, 10:4, and 10:5) were used to identify the optimal molar ratio.…”

Section: Resultsmentioning

confidence: 99%

Molecularly imprinted polyaniline molecular receptor–based chemical sensor for the electrochemical determination of melamine

Regasa

Soreta

Femi

et al. 2020

J of Molecular Recognition

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Molecularly imprinted polymer-modified glassy carbon electrode (GCE)-based electrochemical sensor is prepared using the electropolymerization of aniline in the presence of melamine (MA) as a template. In this work, the advantages of molecularly imprinted conducting polymers (MICPs) and electroanalytical methods were combined to obtain an electronic device with better performances. The sensor performance was evaluated by cyclic voltammetry (CV) and square wave voltammetry (SWV) with the linear range of 0.6-16 × 10 −9 M, quantification limit of 14.9 × 10 −10 M, and detection limit of 4.47 × 10 −10 M (S/N = 3). The selectivity of the sensor was tested in the presence of acetoguanamine (AGA), diaminomethylatrazine (DMT), casein, histidine, and glycine interfering molecules taken at the triple concentration with MA that demonstrated too small current response compared with that of the analyte indicating high specificity of the sensor towards the template. The sensor was successfully applied to determine MA in infant formula samples with significant recovery greater than 96% and relative standard deviation (RSD) less than 4.8%. Moreover, the good repeatability, recyclability, and stability make this sensor device promising for the real-time monitoring of MA in different food stuffs. K E Y W O R D Selectrochemical sensor, glassy carbon electrode, imprinted polyaniline, melamine

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“…The performed binding experiments allowed us to determine the binding capacity of MIP and NIP particles, which represents the amount of SUT bound to the polymers at equilibrium (Q e , mol/g) according to Equation (4) [33]:…”

Section: Imprinting Efficacy and Selectivitymentioning

confidence: 99%

Molecularly Imprinted Polymers (MIPs) as Theranostic Systems for Sunitinib Controlled Release and Self-Monitoring in Cancer Therapy

et al. 2020

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Cytotoxic agents that are used conventionally in cancer therapy present limitations that affect their efficacy and safety profile, leading to serious adverse effects. In the aim to overcome these drawbacks, different approaches have been investigated and, among them, theranostics is attracting interest. This new field of medicine combines diagnosis with targeted therapy; therefore, the aim of this study was the preparation and characterization of Molecularly Imprinted Polymers (MIPs) selective for the anticancer drug Sunitinib (SUT) for the development of a novel theranostic system that is able to integrate the drug controlled release ability of MIPs with Rhodamine 6G as a fluorescent marker. MIPs were synthesized by precipitation polymerization and then functionalized with Rhodamine 6G by radical grafting. The obtained polymeric particles were characterized in terms of particles size and distribution, ξ-potential and fluorescent, and hydrophilic properties. Moreover, adsorption isotherms and kinetics and in vitro release properties were also investigated. The obtained binding data confirmed the selective recognition properties of MIP, revealing that SUT adsorption better fitted the Langmuir model, while the adsorption process followed the pseudo-first order kinetic model. Finally, the in vitro release studies highlighted the SUT controlled release behavior of MIP, which was well fitted with the Ritger-Peppas kinetic model. Therefore, the synthesized fluorescent MIP represents a promising material for the development of a theranostic platform for Sunitinib controlled release and self-monitoring in cancer therapy.

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Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release

Cited by 22 publications

References 22 publications

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Molecularly imprinted polyaniline molecular receptor–based chemical sensor for the electrochemical determination of melamine

Molecularly Imprinted Polymers (MIPs) as Theranostic Systems for Sunitinib Controlled Release and Self-Monitoring in Cancer Therapy

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