Smart biomaterials to enhance the efficiency of immunotherapy in glioblastoma: State of the art and future perspectives

Abadi, Banafshe; Yazdanpanah, Niloufar; Nokhodchi, Ali; Rezaei, Nima

doi:10.1016/j.addr.2021.114035

Cited by 26 publications

(27 citation statements)

References 165 publications

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“…Polymeric structures importantly allow for local and/or sustained release of active therapeutics and have been long a subject of investigation in gliomas, particularly as implants in the post-resection cavity [45][46][47][48][49][50][51][52][53][54]. BCNU wafers were approved for local delivery of carmustine to the glioma resection cavity in 1996, leading the pack on implantable local therapeutics for brain tumors [55,56].…”

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

“…Poly lactic-co-glycolic acid (PLGA) is one of the most used FDA-approved biopolymers. One study investigating PLGA pre-loaded with GM-CSF, CpG-ODN, and tumor lysate demonstrated that it caused recruitment of dendritic cells to tumor tissue in glioma-bearing mice [49].…”

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

“…Injectable hydrogels present another interesting delivery strategy for sustained release of immunotherapeutics, and importantly do not require tumor resection prior to implantation. Hydrogels mimic the extracellular matrix with crosslinked hydrophilic polymeric networks which can support the delivery of a variety of therapeutics [49,56]. Hydrogels must also meet tight thermal phase regulation specifications that allow the substance to be in gel form at body temperature but liquid at room temperature.…”

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

“…Hydrogels must also meet tight thermal phase regulation specifications that allow the substance to be in gel form at body temperature but liquid at room temperature. Once implanted, scaffolds can be designed to release their payload constantly over time or in response to stimuli, such as light, electric or magnetic fields, pH, temperature, or pressure [49,60].…”

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

“…DNA structures are an exciting frontier in bioengineering with a high versatility of structures, including DNA cages, particles, polypods, and hydrogels, improving programmability and biocompatibility [49]. These structures can be applied to deliver immunostimulatory nucleic acids, such as CpG or ODN (unmethylated CpG motif) [49]. In one application, CpG-ODNs loaded onto DNA tetrahedrons or tubes were shown to easily enter dendritic cells [49].…”

Section: Biosensing Materials Implantsmentioning

confidence: 99%

See 4 more Smart Citations

Applying Synthetic Biology with Rational Design to Nature’s Greatest Challenges: Bioengineering Immunotherapeutics for the Treatment of Glioblastoma

Mashouf

Shah

et al. 2021

Immuno

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Improvements in bioengineering methodology and tools have allowed for significant progress in the development of therapeutics and diagnostics in medicine, as well as progress in many other diverse industries, such as materials manufacturing, food and agriculture, and consumer goods. Glioblastomas present significant challenges to adequate treatment, in part due to their immune-evasive and manipulative nature. Rational-design bioengineering using novel scaffolds, biomaterials, and inspiration across disciplines can push the boundaries in treatment development to create effective therapeutics for glioblastomas. In this review, we will discuss bioengineering strategies currently applied across diseases and disciplines to inspire creative development for GBM immunotherapies.

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Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

Section: Polymeric Structures and Hydrogelsmentioning

confidence: 99%

Section: Biosensing Materials Implantsmentioning

confidence: 99%

See 3 more Smart Citations

Applying Synthetic Biology with Rational Design to Nature’s Greatest Challenges: Bioengineering Immunotherapeutics for the Treatment of Glioblastoma

Mashouf

Shah

et al. 2021

Immuno

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Neutrophil‐Targeting Semiconducting Polymer Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Photothermal‐NO‐Immunotherapy of Orthotopic Glioblastoma

Liu,

Cheng,

Zhu

et al. 2024

Advanced Science

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Glioblastoma (GBM) is one of the deadliest primary brain tumors, but its diagnosis and curative therapy still remain a big challenge. Herein, neutrophil‐targeting semiconducting polymer nanotheranostics (SSPNiNO) is reported for second near‐infrared (NIR‐II) fluorescence imaging‐guided trimodal therapy of orthotopic glioblastoma in mouse models. The SSPNiNO are formed based on two semiconducting polymers acting as NIR‐II fluorescence probe as well as photothermal conversion agent, respectively. A thermal‐responsive nitric oxide (NO) donor and an adenosine 2A receptor (A2AR) inhibitor are co‐integrated into SSPNiNO to enable trimodal therapeutic actions. SSPNiNO are surface attached with a neutrophil‐targeting ligand to mediate their effective delivery into orthotopic GBM sites via a “Trojan Horse” manner, enabling high‐sensitive NIR‐II fluorescence imaging. Upon NIR‐II light illumination, SSPNiNO effectively generates heat via NIR‐II photothermal effect, which not only kills tumor cells and induces immunogenic cell death (ICD), but also triggers controlled NO release to strengthen tumor ICD. Additionally, the encapsulated A2AR inhibitor can modulate immunosuppressive tumor microenvironment by blocking adenosine‐A2AR pathway, which further boosts the antitumor immunological effect to observably suppress the orthotopic GBM progression. This study can provide a multifunctional theranostic nanoplatform with cumulative therapeutic actions for NIR‐II fluorescence imaging‐guided effective GBM treatment.

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Polymer materials for constructing therapeutical nanoparticles in photothermal therapy

Li,

Liu,

Zhang

2023

Journal of Polymer Science

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Photothermal therapy (PTT) ablates tumors by thermal effects of photothermal agents (PTAs), and attracts wide attention due to the non‐invasive characteristic. The ideal PTAs are expected to have high photothermal conversion effect under NIR irradiation, as well as targeting abilities and good biocompatibility satisfying the need of application in vivo. Nanoparticles (NPs) are commonly used as anti‐tumor materials, and plenty of researches on therapeutical NPs for PTT treatment have been developed. Among various building blocks for photothermal NPs, polymer materials for biomedical applications have great advantages due to their negligible toxicity, flexibility for functional modification, and ability to integrate multiple therapeutic strategies. This review focuses on the polymer materials utilized in photothermal NP designing, including their application as excellent carriers and powerful PTAs with great PTT effects. Furthermore, the synergy therapy based on polymeric nanoplatform for enhancing PTT therapeutic efficiency will be introduced.

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Smart biomaterials to enhance the efficiency of immunotherapy in glioblastoma: State of the art and future perspectives

Cited by 26 publications

References 165 publications

Applying Synthetic Biology with Rational Design to Nature’s Greatest Challenges: Bioengineering Immunotherapeutics for the Treatment of Glioblastoma

Applying Synthetic Biology with Rational Design to Nature’s Greatest Challenges: Bioengineering Immunotherapeutics for the Treatment of Glioblastoma

Neutrophil‐Targeting Semiconducting Polymer Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Photothermal‐NO‐Immunotherapy of Orthotopic Glioblastoma

Polymer materials for constructing therapeutical nanoparticles in photothermal therapy

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