This study aimed to explore the case study of Brno city regarding smart city models. We analyzed Brno considering smart and sustainable city elements, i.e., smart mobility/public transport, smart technology, smart people, smart governance, smart economy, smart living, and smart environment based on transport, energy, and environment referred herein as the smart city and sustainability model. Therefore, we investigated a case study of Brno city in the Czech Republic. We used qualitative techniques such as case study, exploration, observation, and description. We analyzed and comprehended the trends in the various features of smart city and sustainable development of the city of Brno. The findings showed that Brno city is doing its best to maintain smart city models through its governance organs and structures. The city is also working hard to improve some of the aspects that are still lagging. The ongoing developments and the future ones are based on strategic planning for both the short term and long term such as Brno2023, Brno2030, and Brno2050. It was found that Brno has a very well-planned transport system and is integrated with other aspects such as technology, energy, such as the electricity that moves the trolleybuses and trams, and environment. We strongly conclude that even though Brno city still struggles to achieve total sustainability, it is still a model and reflection of a smart and sustainable city. Finally, we noted that Brno city has very good plans and vision the “DNA” of a smart city. However, the implementation still suffers political willingness.