Smart Contact Lenses for Biosensing Applications

Ma, Xin; Ahadian, Samad; Liu, Song; Zhang, Jingwen; Liu, Sheng-Nan; Cao, Tao; Wang, Lin; Wu, Dong; Barros, Natan Roberto de; Zare, Mohammad Reza; Di̇ltemi̇z, Sibel Emi̇r; Jucaud, Vadim; Zhu, Yangzhi; Zhang, Shiming; Banton, Ethan; Gu, Yue; Nan, Kewang; Xu, Sheng; Dokmeci, Mehmet R.; Khademhosseini, Ali

doi:10.1002/aisy.202000263

Cited by 60 publications

(53 citation statements)

References 116 publications

(190 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2014, Verily, which is regarded as the Google Life Sciences, launched the smart contact lens project. Their challenge was to get reliable tear glucose readings [18]. Even though their development was discontinued because the correlation between blood glucose and tear was too weak [18], it is still encouraging to have further innovation based on tear glucose concentration [57].…”

Section: Ocular Fluid: Tearmentioning

confidence: 99%

“…Their challenge was to get reliable tear glucose readings [18]. Even though their development was discontinued because the correlation between blood glucose and tear was too weak [18], it is still encouraging to have further innovation based on tear glucose concentration [57]. In the following, a recent research carried out by H.D.…”

Section: Ocular Fluid: Tearmentioning

confidence: 99%

“…From this background, scientists are driven to conduct further research in the field of continuous glucose sensing. For example, in 2014, the biotech-company Verily of Google tried to use a 2-layer smart contact lens combined with a radio chip to monitor blood glucose (BG) variation [18]. However, the results revealed that it is difficult to get a reliable mapping between glucose level in the blood and the tear fluid [19].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Xue

Thalmayer

Zeising

et al. 2022

Sensors

View full text Add to dashboard Cite

Diabetes is a chronic and, according to the state of the art, an incurable disease. Therefore, to treat diabetes, regular blood glucose monitoring is crucial since it is mandatory to mitigate the risk and incidence of hyperglycemia and hypoglycemia. Nowadays, it is common to use blood glucose meters or continuous glucose monitoring via stinging the skin, which is classified as invasive monitoring. In recent decades, non-invasive monitoring has been regarded as a dominant research field. In this paper, electrochemical and electromagnetic non-invasive blood glucose monitoring approaches will be discussed. Thereby, scientific sensor systems are compared to commercial devices by validating the sensor principle and investigating their performance utilizing the Clarke error grid. Additionally, the opportunities to enhance the overall accuracy and stability of non-invasive glucose sensing and even predict blood glucose development to avoid hyperglycemia and hypoglycemia using post-processing and sensor fusion are presented. Overall, the scientific approaches show a comparable accuracy in the Clarke error grid to that of the commercial ones. However, they are in different stages of development and, therefore, need improvement regarding parameter optimization, temperature dependency, or testing with blood under real conditions. Moreover, the size of scientific sensing solutions must be further reduced for a wearable monitoring system.

show abstract

Section: Ocular Fluid: Tearmentioning

confidence: 99%

Section: Ocular Fluid: Tearmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Xue

Thalmayer

Zeising

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…Artificial intelligence can be a valuable addition to the study of the therapeutic effects of these smart devices, while machine learning algorithms can provide long-term monitoring of an individual’s health status, thus further improving the course of treatment [ 146 ]. Contact lenses can potentially offer the technical and material novelties required for the next generation of precision devices for medical applications [ 147 ]. Moreover, combining medical contact lenses with those used as fashion accessories would promote their use in daily life.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

et al. 2022

View full text Add to dashboard Cite

In recent years, wearable contact lenses for medical applications have attracted significant attention, as they enable continuous real-time recording of physiological information via active and noninvasive measurements. These devices play a vital role in continuous monitoring of intraocular pressure (IOP), noninvasive glucose monitoring in diabetes patients, drug delivery for the treatment of ocular illnesses, and colorblindness treatment. In specific, this class of medical devices is rapidly advancing in the area of drug loading and ocular drug release through incorporation of electrospun fibers. The electrospun fiber matrices offer a high surface area, controlled morphology, wettability, biocompatibility, and tunable porosity, which are highly desirable for controlled drug release. This article provides an overview of the advances of contact lens devices in medical applications with a focus on four main applications of these soft wearable devices: (i) IOP measurement and monitoring, (ii) glucose detection, (iii) ocular drug delivery, and (iv) colorblindness treatment. For each category and application, significant challenges and shortcomings of the current devices are thoroughly discussed, and new areas of opportunity are suggested. We also emphasize the role of electrospun fibers, their fabrication methods along with their characteristics, and the integration of diverse fiber types within the structure of the wearable contact lenses for efficient drug loading, in addition to controlled and sustained drug release. This review article also presents relevant statistics on the evolution of medical contact lenses over the last two decades, their strengths, and the future avenues for making the essential transition from clinical trials to real-world applications.

show abstract

“…SCLs by enhancing the usability and minimizing side effects. [11,31,32] Through significant multi-disciplinary research efforts, innovations of SCLs with the ability to 1) continuously monitor real-time physiological signals in a wireless manner, 2) provide reliable diagnosis, and 3) offer beneficial feedback to users for follow-up treatment, which will ultimately enable personalized medicine.…”

Section: Introductionmentioning

confidence: 99%

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

Self Cite

View full text Add to dashboard Cite

The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

show abstract

Smart Contact Lenses for Biosensing Applications

Cited by 60 publications

References 116 publications

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

Commercial and Scientific Solutions for Blood Glucose Monitoring—A Review

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Contact Info

Product

Resources

About