Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment

Egorova, Vera S.; Kolesova, Ekaterina; Lopus, Manu; Yan, Neng; Parodi, Alessandro; Zamyatnin, Andrey A.

doi:10.3390/pharmaceutics15071848

Cited by 8 publications

(3 citation statements)

References 140 publications

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“…Introduction of linkers, cleavable by proteases, enriched in acidic TME (i.e., cathepsins, metalloproteases etc.) is a widely used approach in nanotechnology (for more information see review [116]). The resulting nanoparticles (NPs) were efficiently internalized into tumor cells and tumor-associated macrophages (TAMs), achieving a remarkable 90% inhibition of tumor growth in vivo compared to the control PBS-treated group and a 60% inhibition compared to NPs carrying paclitaxel without functionalization.…”

Section: Nanotherapy Options Aimed At Targeting Tams 61 Tam Reprogram...mentioning

confidence: 99%

Reprogramming Tumor-Associated Macrophage Using Nanocarriers: New Perspectives to Halt Cancer Progression

Kuznetsova,

Kolesova,

Parodi

et al. 2024

Pharmaceutics

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Cancer remains a significant challenge for public healthcare systems worldwide. Within the realm of cancer treatment, considerable attention is focused on understanding the tumor microenvironment (TME)—the complex network of non-cancerous elements surrounding the tumor. Among the cells in TME, tumor-associated macrophages (TAMs) play a central role, traditionally categorized as pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. Within the TME, M2-like TAMs can create a protective environment conducive to tumor growth and progression. These TAMs secrete a range of factors and molecules that facilitate tumor angiogenesis, increased vascular permeability, chemoresistance, and metastasis. In response to this challenge, efforts are underway to develop adjuvant therapy options aimed at reprogramming TAMs from the M2 to the anti-tumor M1 phenotype. Such reprogramming holds promise for suppressing tumor growth, alleviating chemoresistance, and impeding metastasis. Nanotechnology has enabled the development of nanoformulations that may soon offer healthcare providers the tools to achieve targeted drug delivery, controlled drug release within the TME for TAM reprogramming and reduce drug-related adverse events. In this review, we have synthesized the latest data on TAM polarization in response to TME factors, highlighted the pathological effects of TAMs, and provided insights into existing nanotechnologies aimed at TAM reprogramming and depletion.

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Section: Nanotherapy Options Aimed At Targeting Tams 61 Tam Reprogram...mentioning

confidence: 99%

Reprogramming Tumor-Associated Macrophage Using Nanocarriers: New Perspectives to Halt Cancer Progression

Kuznetsova,

Kolesova,

Parodi

et al. 2024

Pharmaceutics

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“…However, recent advances in imaging tools that target cathepsin B have been proposed, which can help distinguish tumour boundaries and guide surgical early diagnosis of tumours [46]. In addition, pro-drugs and other target therapeutic agents that respond to cathepsin B have been proposed and used in cancer treatment, and some of them are already on the market [46,47].…”

Section: Challenges and Future Directions In Cathepsin B-targeted The...mentioning

confidence: 99%

Role of Cathepsin B Expression in Oral Squamous Cell Carcinoma: A Comprehensive Review

Sagar,

Gadkari,

Hiwale

et al. 2024

Cureus

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This comprehensive review delves into the intricate landscape of oral squamous cell carcinoma (OSCC) by examining the role of cathepsin B expression in its pathogenesis. OSCC, a prevalent and clinically significant oral malignancy, poses a considerable global health burden, necessitating a thorough exploration of its underlying molecular mechanisms. Cathepsin B, a lysosomal cysteine protease, emerges as a critical player in OSCC, influencing tumour initiation, invasion, and metastasis. The review begins with a brief overview of OSCC, emphasizing its epidemiological and clinical features, followed by exploring the significance of studying cathepsin B expression in this context. In the manuscript, the structure and function of cathepsin B are elucidated, providing a foundation for understanding its aberrant expression in OSCC. Clinical studies revealing correlations with tumour grade and stage, along with prognostic significance, are scrutinized, offering insights into the potential diagnostic and prognostic utility of cathepsin B. The biological functions of cathepsin B in OSCC, including its impact on tumour invasion and modulation of apoptosis, are comprehensively discussed. The Therapeutic Implications section explores targeting cathepsin B as a potential strategy, emphasizing the need for future research to overcome associated challenges. In the Conclusion section, the review synthesizes key findings, delineates implications for future research, and highlights the potential impact of cathepsin B on OSCC diagnosis and treatment, contributing to the ongoing efforts to advance our understanding of this complex malignancy, which is associated with a high mortality rate and improve clinical outcomes.

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“…Micro-and nanoparticle platforms based on calcium carbonate (CaCO 3 ) promise advancing drug delivery in cancer therapy [9,10]. To minimize the off-targeting effect, controlled-release systems responsive to external conditions like temperature, enzyme activity, or pH emerge as a viable approach [9,11]. The capability of degrading porous CaCO 3 nanoparticles layer by layer as the pH level decreases provides control over the release rate of molecules from the subsequent layers of the porous matrix, as well as the oxygen enrichment time for a further excitation in cancer cells/tumors [9,12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Submicron CaCO3 Particles in 3D-Printed Microfluidic Chips Supporting Advection and Diffusion Mixing

Reznik,

Kolesova,

Pestereva

et al. 2024

Micromachines

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Microfluidic technology provides a solution to the challenge of continuous CaCO3 particle synthesis. In this study, we utilized a 3D-printed microfluidic chip to synthesize CaCO3 micro- and nanoparticles in vaterite form. Our primary focus was on investigating a continuous one-phase synthesis method tailored for the crystallization of these particles. By employing a combination of confocal and scanning electron microscopy, along with Raman spectroscopy, we were able to thoroughly evaluate the synthesis efficiency. This evaluation included aspects such as particle size distribution, morphology, and polymorph composition. The results unveiled the existence of two distinct synthesis regimes within the 3D-printed microfluidic chips, which featured a channel cross-section of 2 mm2. In the first regime, which was characterized by chaotic advection, particles with an average diameter of around 2 μm were produced, thereby displaying a broad size distribution. Conversely, the second regime, marked by diffusion mixing, led to the synthesis of submicron particles (approximately 800–900 nm in diameter) and even nanosized particles (70–80 nm). This research significantly contributes valuable insights to both the understanding and optimization of microfluidic synthesis processes, particularly in achieving the controlled production of submicron and nanoscale particles.

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Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment

Cited by 8 publications

References 140 publications

Reprogramming Tumor-Associated Macrophage Using Nanocarriers: New Perspectives to Halt Cancer Progression

Reprogramming Tumor-Associated Macrophage Using Nanocarriers: New Perspectives to Halt Cancer Progression

Role of Cathepsin B Expression in Oral Squamous Cell Carcinoma: A Comprehensive Review

Synthesis of Submicron CaCO3 Particles in 3D-Printed Microfluidic Chips Supporting Advection and Diffusion Mixing

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