Multidisciplinary, interdisciplinary, and transdisciplinary collaboration (TDC) continue to address complex societal problems such as sustainable development, global environmental change, and public health challenges. Nature-based design (NBD) methods including biomimicry, biomorphism, biophilia, bio-utilization and zoomorphism are essential for the design of the sustainable built environment (SBE). Currently, there is no transdisciplinary collaboration framework (TCF) to support the NBD of the SBE. The first step to fill this gap is through systematically exploring the applications of multidisciplinary research (MDR) in building design and by conducting a case study on the challenges to the MDR in the application of NBD methods for the SBE in the Faculty of Engineering and the Faculty of Science at the University of Strathclyde, Glasgow, UK. The systematic literature review and the survey results of academics on MDR collaboration showed a lack of transdisciplinary research (TDR) due to limited communication between disciplines. The research findings showed a lack of communication between academia and the Architecture, Engineering, and Construction (AEC) industry to advance NBD innovations for the SBE. The findings indicated that a TCF for research on NBD is needed to support knowledge exchange within academia and with industry for reducing the negative impacts of the building industry. Findings from the current research and future research will be used to develop and test a general TCF and then to develop a TCF for the NBD of the SBE aligned with the RIBA Plan of Work.