Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer

Abdellatif, Ahmed A. H.; Mohammed, Ahmed M.; Saleem, Imran; Alsharidah, Mansour; Rugaie, Osamah Al; Ahmed, Fatma; Osman, Shaaban K.

doi:10.3390/pharmaceutics14030661

Cited by 33 publications

(12 citation statements)

References 53 publications

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“…Hydrogels based on CHT are gaining considerable interest for biomedical applications due to its biocompatibility, biodegradability, non-toxicity, and biological features, such as bio-adhesiveness, antibacterial, hemostatic, and anti-inflammatory properties. Altogether, these properties are pivotal in the design of biomedical systems for smart drug delivery [ 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], wound healing [ 136 ], and regenerative medicine [ 137 ].…”

Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.

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Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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“…In addition, a notable volume reduction in the TNBC spheroids is achieved, whereas free drugs only reduce growth rate [ 198 ]. Moreover, 5-Fluorouracil loaded chitosan hydrogel exhibits good physicochemical properties and in vitro sustained release profiles, resulting in greater inhibition of breast cancer cell viability and in vivo antitumor activity with minor side effects [ 199 ]. In addition, gefitinib-loaded cellulose acetate butyrate nanoparticles incorporated into chitosan/βGP hydrogels is established for intratumoral administration in mice bearing breast cancer and displayed a greater cytotoxic effect in comparison with a free drug.…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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“…Because of the limitations of traditional chemotherapy and the toxicity of chemotherapeutic drugs to normal tissues and organs in oral cancer, the smart drug delivery system based on hydrogels has become a popular research direction. Related studies have mainly focused on the methods of sustained-release drug delivery and stimulation response [ 178 , 179 , 180 ]. The smart hydrogels have precise reactions to temperature, pH, and tiny changes in light.…”

Section: Prospective and Conclusionmentioning

confidence: 99%

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Zhao

Ran

Xie

et al. 2022

Gels

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At present, an oral tumor is usually treated by surgery combined with preoperative or postoperative radiotherapies and chemotherapies. However, traditional chemotherapies frequently result in substantial toxic side effects, including bone marrow suppression, malfunction of the liver and kidneys, and neurotoxicity. As a new local drug delivery system, the smart drug delivery system based on hydrogel can control drug release in time and space, and effectively alleviate or avoid these problems. Environmentally responsive hydrogels for smart drug delivery could be triggered by temperature, photoelectricity, enzyme, and pH. An overview of the most recent research on smart hydrogels and their controlled-release drug delivery systems for the treatment of oral cancer is given in this review. It is anticipated that the local drug release method and environment-responsive benefits of smart hydrogels will offer a novel technique for the low-toxicity and highly effective treatment of oral malignancy.

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Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer

Cited by 33 publications

References 53 publications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

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