Smart micelle@polydopamine core–shell nanoparticles for highly effective chemo–photothermal combination therapy

Abstract

In this investigation, we have designed and synthesized a novel core-shell polymer nanoparticle system for highly effective chemo-photothermal combination therapy. A nanoscale DSPE-PEG micelle encapsulating doxorubicin (Dox-M) was designed as a core, and then modified by a polydopamine (PDA) shell for photothermal therapy and bortezomib (Btz) administration (Dox-M@PDA-Btz). The facile conjugation of Btz to the catechol-containing PDA shell can form a reversible pH-sensitive boronic acid-catechol conjugate to create a stimuli-responsive drug carrier system. As expected, the micelle@PDA core-shell nanoparticles exhibited satisfactory photothermal efficiency, which has potential for thermal ablation of malignant tissues. In addition, on account of the PDA modification, both Dox and Btz release processes were pH-dependent and NIR-dependent. Both in vitro and in vivo studies illustrated that the Dox-M@PDA-Btz nanoparticles coupled with laser irradiation could enhance the cytotoxicity, and thus combinational therapy efficacy was achieved when integrating Dox, Btz, and PDA into a single nanoplatform. Altogether, our current study indicated that the micelle@polydopamine core-shell nanoparticles could be applied for NIR/pH-responsive sustained-release and synergized chemo-photothermal therapy for breast cancer.

Double Drug-Loaded and pH/Thermal Sensitive Multifunctional Drug Delivery System for Tumor Photoacoustic Imaging-Guided Enhanced Chemo/Photothermal Therapy

“…AuNRs@MSN were synthesized according to the reported previously [26]. To remove excess CTAB from AuNRs, 30…”

Amine‐Triggered Dopamine Polymerization: From Aqueous Solution to Organic Solvents

“…Notably, all of these methods are limited in aqueous solution and hamper its wide application. For example, we cannot use water‐soluble templates to get hollow PDA structures, which are greener and easier to remove than using common hard or soft templates, such as SiO 2 , PS sphere, or 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐ N ‐ [methoxy(polyethylene glycol)‐2000] (DSPE‐PEG) micelles . Recently, Lee and co‐workers first reported DA polymerization in ethanol or methanol by the proposed mechanism of incorporation of piperidine into the PDA backbone, these resultant molecules undergo further chemical cross‐linking or physical assembly, resulting in PDA structures, but the effects of other amines on DA polymerization are not demonstrated further.…”

A biomimetic nanoparticle-enabled toxoid vaccine against melittin

“…12,13 After ultraviolet irradiation, the diacetylene monomer will form ene-yne alternating polymer chains, which are responsible for the sensitivity of PDA nanoparticles to environmental changes, such as temperature variation, solvent changes, vapor exposure and pH variation, showing corresponding color change (blue to red) and emissive activation. [14][15][16] The obtained PDA nanoparticles with specific vesicle structure are capable of sensing, attracting and neutralizing PFTs without causing protein denaturation, mimicking the role of normal cell membranes. 17,18 In our study, we prepared a PDA-melittin complex to enhance immunity against melittin by incubation with PDA nanoparticles.…”