Smart nanofibres for specific and ultrasensitive nanobiosensors and drug delivery systems

Pashchenko, A. B.; Stuchlíková, Simona; Varvařovská, Leontýna; Firment, Peter; Staňková, Laura; Nečasová, Andrea; Filipejová, Zita; Urbanová, Lucie; Jarošíková, Taťána; Nečas, Alois; Amler, Evžen

doi:10.2754/avb202291020163

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…This increase in sensitivity is secured mainly using nanofibers. Their characteristic structure with the immense number of pores [19][20][21] creates an enormous active surface that can be modified, enriched, or functionalized [22,23].…”

Section: Introductionmentioning

confidence: 99%

The Development of a Specific Nanofiber Bioreceptor for Detection of Escherichia coli and Staphylococcus aureus from Air

Varvařovská,

Kudrna,

Sopko

et al. 2024

Biosensors

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Polluted air and the presence of numerous airborne pathogens affect our daily lives. The sensitive and fast detection of pollutants and pathogens is crucial for environmental monitoring and effective medical diagnostics. Compared to conventional detection methods (PCR, ELISA, metabolic tests, etc.), biosensors bring a very attractive possibility to detect chemicals and organic particles with the mentioned reliability and sensitivity in real time. Moreover, by integrating nanomaterials into the biosensor structure, it is possible to increase the sensitivity and specificity of the device significantly. However, air quality monitoring could be more problematic even with such devices. The greatest challenge with conservative and sensing methods for detecting organic matter such as bacteria is the need to use liquid samples, which slows down the detection procedure and makes it more difficult. In this work, we present the development of a polyacrylonitrile nanofiber bioreceptor functionalized with antibodies against bacterial antigens for the specific interception of bacterial cells directly from the air. We tested the presented novel nanofiber bioreceptor using a unique air filtration system we had previously created. The prepared antibody-functionalized nanofiber membranes for air filtration and pathogen detection (with model organisms E. coli and S. aureus) show a statistically significant increase in bacterial interception compared to unmodified nanofibers. Creating such a bioreceptor could lead to the development of an inexpensive, fast, sensitive, and incredibly selective bionanosensor for detecting bacterial polluted air in commercial premises or medical facilities.

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Section: Introductionmentioning

confidence: 99%

The Development of a Specific Nanofiber Bioreceptor for Detection of Escherichia coli and Staphylococcus aureus from Air

Varvařovská,

Kudrna,

Sopko

et al. 2024

Biosensors

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The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

Veg,

Hashmi,

Raza

et al. 2024

Chemistry & Biodiversity

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Nanomaterials owing to their small size imparts them with unique properties and they can also be designed and engineered according to the specific need. The use of nanoparticles (NPs) in medicine is particularly revolutionary as it has opened new therapeutic avenues to diagnose, treat and manage diseases in an efficient and timely manner. The review article presents the biomedical applications of nanomaterials including bioimaging, magnetic hypothermia and photoablation therapy, with a particular focus on disease diagnosis and targeted drug delivery. Nanobiosensors are highly specific and can be delivered into cells to investigate important biomarkers. They are also used for targeted drug delivery and deliver theranostic agents to specific sites of interest. The review also explores the role of nano‐based drug delivery systems for the management and treatment of nervous system disorders, tuberculosis and orthopaedics. The nano‐capsulated drugs can be transported by blood to the targeted site for a sustained release over a prolonged period. Some other applications like their role in invasive surgery, photodynamic therapy and quantum dot imaging have also been explored. Despite that, the safety concerns related to nanomedicine should be comprehended as well as the biodistribution of NPs in the body and the mechanistic insight.

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