Smart platform for the time since death determination from vitreous humor cystine

Ansari, Niha; Lodha, Anand; Menon, Shobhana K.

doi:10.1016/j.bios.2016.06.042

Cited by 19 publications

(12 citation statements)

References 40 publications

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“…In recent years, with advances in the computational capability of smartphones, smartphone-based colourimetric sensors have attracted increasing attention 26 27 28 29 30 . Colourimetric data obtained from digital images can be converted to analyte concentrations with a built-in smartphone app or Adobe Photoshop CS6 software by calculating the RGB values 28 29 . Smartphone-based colourimetric methods have the advantages of low cost, portability, possibility for on-site image recording and ease of implementation, and thus provide a new direction for colourimetric assays.…”

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confidence: 99%

Multipath colourimetric assay for copper(II) ions utilizing MarR functionalized gold nanoparticles

Wang

et al. 2017

Sci Rep

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We use the multiple antibiotic resistance regulator (MarR), as a highly selective biorecognition elements in a multipath colourimetric sensing strategy for the fast detection of Cu2+ in water samples. The colourimetric assay is based on the aggregation of MarR-coated gold nanoparticles in the presence of Cu2+ ions, which induces a red-to-purple colour change of the solution. The colour variation in the gold nanoparticle aggregation process can be used for qualitative and quantitative detection of Cu2+ by the naked eye, and with UV–vis and smartphone-based approaches. The three analysis techniques used in the multipath colourimetric assay complement each other and provide greater flexibility for differing requirements and conditions, making the assay highly applicable for Cu2+ detection. Under optimal conditions, the Cu2+ concentration was quantified in less than 5 min with limits of detection for the naked eye, UV–vis and smartphone-based approaches of 1 μM, 405 nM and 61 nM, respectively. Moreover, the sensing system exhibited excellent selectivity and practical application for Cu2+ detection in real water samples. Thus, our strategy has great potential for application in on-site monitoring of Cu2+, and the unique response of MarR towards copper ions may provide a new approach to Cu2+ sensing.

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confidence: 99%

Multipath colourimetric assay for copper(II) ions utilizing MarR functionalized gold nanoparticles

Wang

et al. 2017

Sci Rep

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“…To that end, quantum dots [65,66], plasmonic nanoparticles [67][68][69][70], carbon nanotubes [71] and graphene [72] have been widely explored for the development of affinity-based nanoprobes to detect common narcotics [65,66], anabolic steroids [71], drugs with abuse potential [69], explosives [67,72] and pathogens that can potentially be linked to bioterrorism [68], as well as to determine time since death [70]. Moreover, wearable biosensors can monitor continuously and in real time adverse lifestyle habits associated with criminal behaviour, such as the excessive use of alcohol [73].…”

Section: Molecular Sensingmentioning

confidence: 99%

Carbon Dots for Forensic Applications: A Critical Review

Verhagen

Kelarakis

2020

Nanomaterials

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Owing to their superior fluorescence performance, inexpensive synthesis and nontoxic nature, carbon dots (C-dots) are systematically explored in a variety of applications; in this review, we outline and critically discuss recent trends with respect to their potential exploitation in criminal investigation, forensic toxicology and anti-counterfeit interventions. Capitalising on their colour-tuneable behaviour (in the sense that they adopt different colours with respect to the incident radiation), C-dot-based compositions are ideal for the visual enhancement of latent fingerprints, affording improved contrast against multicoloured and patterned backgrounds. As highly sensitive and highly selective optical nanoprobes, C-dots show excellent analytical performance in detecting biological compounds, drugs, explosives, heavy metals and poisonous reactants. In addition, benefiting from their versatile structural and chemical composition, C-dots can be incorporated into ink and polymeric formulations capable of functioning as a new generation of cost-effective barcodes and security nanotags for object authentication and anti-counterfeit applications. Translating these encouraging research outcomes into real-life innovations with significant social and economic impact requires an open, multidisciplinary approach and a close synergy between materials scientists, biologists, forensic investigators and digital engineers.

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“…In the near future, this method can be developing a microfluidic system, smart approach-based detection to estimate the Fig. 4 Application of nanoparticles in sedative drug detection: schematic diagram of gold nanoparticles interaction with clonazepam cysteine concentration and correlate it with TSD estimation (Ansari et al 2016). Recently, Williams and his colleagues have developed a flow cytometry-based method to estimate TSD.…”

Section: Estimation Of Time Since Deathmentioning

confidence: 99%

New perspective of nanotechnology: role in preventive forensic

Pandya

Shukla

2018

Egypt J Forensic Sci

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Background: Generally, material scientist discussing new-fangled nanotechnology research and its conversation turns to the commercial aspects or potential issues around health, safety, and the environment. In recent years, few of them have been shown interest to apply nanotechnology for forensic purposes which are related to societal or community issues. Main text: In forensic science, nanotechnology majorly is applied to develop reactive ('smart') materials; microchip technology; nanomanipulators; nanoimaging tools for visualization. These advances in forensic technologies have mainly been focused on analytical techniques. These techniques are based on nanomaterials that are able to provide either improved performance over conventional techniques or enable to collect information from a crime scene that would not otherwise have been possible ever. Moreover, some crucial forensic issues such as cost and time effectiveness, wide availability, accuracy, and reliability of results are major concerns in forensic investigation and security. Conclusion: With the help of this review article, an attempt was made to elucidate how nanotechnologies could be crucial in addressing current forensic investigation issues such as collection and analysis of evidence from the crime scene and how these technologies may be helpful in preventive forensic and security measures.

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Smart platform for the time since death determination from vitreous humor cystine

Cited by 19 publications

References 40 publications

Multipath colourimetric assay for copper(II) ions utilizing MarR functionalized gold nanoparticles

Multipath colourimetric assay for copper(II) ions utilizing MarR functionalized gold nanoparticles

Carbon Dots for Forensic Applications: A Critical Review

New perspective of nanotechnology: role in preventive forensic

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