Smart Polymersomes: Formation, Characterisation and Applications

Pearson, Russell; Avila-Olias, Milagros; Joseph, Adrian; Nyberg, Sophie; Battaglia, Giuseppe

doi:10.1039/9781849736800-00179

Cited by 8 publications

(3 citation statements)

References 146 publications

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“…At concentrations lower than the CMC, the population of polymersomes decreased less than that of micelles, which means that this form was stable even at concentrations much lower than the CMC. Pearson et al 20 reported that, in general, micelles are thermodynamically unstable and that they tend to join together and form polymersomes, which are more stable than micelles.…”

Section: A Excitation Wavelength (Nm) Fluorescence Intensity (Au)mentioning

confidence: 99%

A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells

Erfani‐Moghadam¹,

Nomani²,

Zamani³

et al. 2014

IJN

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Curcumin is a potent natural anticancer agent, but its effectiveness is limited by properties such as very low solubility, high rate of degradation, and low rate of absorption of its hydrophobic molecules in vivo. To date, various nanocarriers have been used to improve the bioavailability of this hydrophobic biomaterial. This study investigates the encapsulation of curcumin in a novel nanostructure of monomethoxy poly(ethylene glycol)-oleate (mPEG-OA) and its anticancer effect. Tests were done to determine the critical micelle concentration (CMC), encapsulation efficiency, drug-loading efficiency, and cytotoxicity (against U87MG brain carcinoma cells and HFSF-PI3 cells as normal human fibroblasts) of some nanodevice preparations. The results of fluorescence microscopy and cell-cycle analyses indicated that the in vitro bioavailability of the encapsulated curcumin was significantly greater than that of free curcumin. Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 μM and 24 μM, respectively. The Annexin-V-FLUOS assay was used to quantify the apoptotic effect of the prepared nanostructures. Apoptosis induction was observed in a dose-dependent manner after curcumin-loaded mPEG-OA treatments. Two common self-assembling structures, micelles and polymersomes, were observed by atomic force microscopy and dynamic light scattering, and the abundance of each structure was dependent on the concentration of the diblock copolymer. The mPEG-OA micelles had a very low CMC (13.24 μM or 0.03 g/L). Moreover, atomic force microscopy and dynamic light scattering showed that the curcumin-loaded mPEG-OA polymersomes had very stable structures, and at concentrations 1,000 times less than the CMC, at which the micelles disappear, polymersomes were the dominant structures in the dispersion with a reduced size distribution below 150 nm. Overall, the results from these tests revealed that this nanocarrier can be considered as an appropriate drug delivery system for delivering curcumin to cancer cells. © 2014 Erfani-Moghadam et al

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Section: A Excitation Wavelength (Nm) Fluorescence Intensity (Au)mentioning

confidence: 99%

A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells

Erfani‐Moghadam¹,

Nomani²,

Zamani³

et al. 2014

IJN

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“…[35] It is noteworthy that polymersomes are thermodynamically more stable than micelles as previously described. [42] Overall, the average size of prepared nanoparticles in the present study was in appropriate range to show enhanced permeability and retention effect (EPR) for passive targeting of tumor sites in the systemic administration. [43] The zeta potential was also determined as À 6.31 � 0.29 mV.…”

Section: Dls and Zeta Potential Analysismentioning

confidence: 72%

Encapsulation of Docetaxel into Diblock Polymeric Polymersome as a Nanodrug

et al. 2020

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In this study, a chemotherapeutic drug, Docetaxel (DTX) was loaded in a di-block polymeric nanoparticles (NPs) consisted of Oleate and Poly (ethylene glycol). First, the OA-PEG 1000 units were synthesized by the esterification reaction and confirmed by 1 HNMR and FTIR spectroscopies. After determination of critical micelle concentration (CMC), the DTX was loaded into the OA-PEG 1000 NPs using the solvent displacement method. The encapsulation efficiency and loading capacity percentages were estimated as 22.2 % and 0.43 % respectively. The average size (obtained by DLS) and zeta potential of NPs were as 221.3 � 8.06 nm and 6.31 � 0.29 mV respectively indicating polymersome formation. The morphology of NPs in AFM images was almost spherical with a diameter of about 207.1 � 28.36 nm which was approximate to DLS outcomes. These results demonstrated that di-block polymeric NPs can be potentially practical for carrying and delivering DTX as a novel anticancer pharmaceutical.

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“…Traditional drug formulations are often associated with poor protection of the active compound from the biological environments and a lack of controlled release. 1 In this chapter we will present briefly the computational methods that are currently chapter-in-silico-self-assembly-revised-v1-ACS_modified1.doc Printed 06/08/y 2 used to investigate the self-assembly process, as well as the drug loading and release from nanoparticles. In the second part, representative in silico studies describing these processes will be presented, with a special emphasis on the techniques that are specific for each step and on the innovative approaches (multiscale simulations, doubly thermoresponsive nanoparticles, simultaneous delivery of multiple drugs, etc.).…”

Section: Introductionmentioning

confidence: 99%

In SilicoSelf-Assembly of Nanoparticles with Applications in Drug Delivery

Selwa

Iorga

2017

ACS Symposium Series

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The use of nanoparticles for drug delivery applications has known an increasing success during the last years, together with the computational methods that are particularly useful for modeling the self-assembly process. The granularity at which particles are represented, force field parameters, initial setup and system composition are important factors influencing the outcome of simulations that have been the subject of intense research. In this chapter, the applications of these in silico approaches in drug delivery will be discussed, highlighting the importance o f n a n o p a r t i c l e 's c o m p o s ition: peptides, copolymers, lipids, or a mixture of them.

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Smart Polymersomes: Formation, Characterisation and Applications

Cited by 8 publications

References 146 publications

A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells

A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells

Encapsulation of Docetaxel into Diblock Polymeric Polymersome as a Nanodrug

In SilicoSelf-Assembly of Nanoparticles with Applications in Drug Delivery

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