Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes

Liu, Shixian; Shen, Zhuping; Deng, Liping; Liu, Guozhen

doi:10.1016/j.bios.2022.114251

Cited by 48 publications

(32 citation statements)

References 36 publications

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“…It was observed that this sensing interface was able to respond to insulin (Figure e). Similar to the previous study, in the absence of insulin, the methylene blue (MB)-labeled aptamer on EGaIn provided a strong characteristic redox peak of MB . In the presence of insulin, the binding of insulin caused the structure switching of the aptamer to have MB being far away from the electrode surface, thus achieving suppressed electrochemical response.…”

Section: Resultssupporting

confidence: 69%

Surface Modification of Liquid Metal with p-Aniline Derivatives toward Bioapplications: Biosensing as an Example

Huang

Zou

Liu

2022

ACS Appl. Mater. Interfaces

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It is a long-lasting research topic to avoid the formation of oxidation layers on gallium-based liquid metals. This study has developed a simple general method for modification of the eutectic gallium−indium (EGaIn) surface with p-aniline derivatives to introduce a monolayer of organic molecules with versatile functional groups. The binding affinity of carboxylic acid groups, amine groups, or thiol groups with EGaIn is in the order SH > NH 2 > COOH. For the first time, it is evidenced that both NH 2 and SH groups can coexist on the EGaIn nanoparticle surface with the binding affinities of 30 and 70%, respectively. The formation of these organic molecules on the EGaIn surface antioxidizes and thus stabilizes the EGaIn nanoparticles, while increasing the conductivity of EGaIn significantly. The resulting EGaIn nanoparticles have very good distribution in both ethanol and aqueous solutions and rich surface chemistry, making them suitable for the following attachment of biomolecules such as aptamers, antibodies, or enzymes for biomedical applications. As an example, the EGaIn surface is successfully modified with p-aminobenzoic acid followed by the attachment of an insulin aptamer, which can be used for the electrochemical detection of insulin with the lowest detectable concentration limit of 1 pM. This study reveals the modification of EGaIn nanoparticles with p-aniline derivatives with versatile functional groups to antioxidize EGaIn in a biological environment, opening a door for gallium-based liquid metals toward biomedical applications.

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Section: Resultssupporting

confidence: 69%

Surface Modification of Liquid Metal with p-Aniline Derivatives toward Bioapplications: Biosensing as an Example

Huang

Zou

Liu

2022

ACS Appl. Mater. Interfaces

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“…Amperometric sensing can be chosen for use in the study of microscopic domains, detection in microflow systems, single-cell processes, and in vivo monitoring of neurochemical events. For instance, Liu et al reported an amperometric platform combined with a portable biochip, a Bluetooth transmission system for simultaneous insulin, and glucose monitoring in saliva for practical diagnosis of diabetes and other insulin-resistance-associated diseases [ 65 ]. Another electrochemical technique, voltammetry, was also used in smartphone electrochemical sensor measurements [ 64 , 66 ].…”

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

et al. 2022

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Many emerging technologies have the potential to improve health care by providing more personalized approaches or early diagnostic methods. In this review, we cover smartphone-based multiplexed sensors as affordable and portable sensing platforms for point-of-care devices. Multiplexing has been gaining attention recently for clinical diagnosis considering certain diseases require analysis of complex biological networks instead of single-marker analysis. Smartphones offer tremendous possibilities for on-site detection analysis due to their portability, high accessibility, fast sample processing, and robust imaging capabilities. Straightforward digital analysis and convenient user interfaces support networked health care systems and individualized health monitoring. Detailed biomarker profiling provides fast and accurate analysis for disease diagnosis for limited sample volume collection. Here, multiplexed smartphone-based assays with optical and electrochemical components are covered. Possible wireless or wired communication actuators and portable and wearable sensing integration for various sensing applications are discussed. The crucial features and the weaknesses of these devices are critically evaluated.

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“…In order to acquire more disease information using a single smartphone-based detection system, some researchers have been trying to construct systems which enable the simultaneous detection of glucose in saliva and other diabetes-related indicators. Liu et al established a smartphone-based portable biochip to simultaneously monitor glucose and insulin for precise diagnosis of prediabetes/diabetes ( Figure 2 F) [ 82 ]. In this study, the realization of continuous real-time detection of glucose and insulin in saliva demonstrated its possibility of becoming a precise and real-time monitoring tool for diabetes management.…”

Section: Smartphone-based Portable Glucose Monitoringmentioning

confidence: 99%

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Yan

Liu

2022

Sensors

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As a vital biomarker, glucose plays an important role in multiple physiological and pathological processes. Thus, glucose detection has become an important direction in the electrochemical analysis field. In order to realize more convenient, real-time, comfortable and accurate monitoring, smartphone-based portable, wearable and implantable electrochemical glucose monitoring is progressing rapidly. In this review, we firstly introduce technologies integrated in smartphones and the advantages of these technologies in electrochemical glucose detection. Subsequently, this overview illustrates the advances of smartphone-based portable, wearable and implantable electrochemical glucose monitoring systems in diverse biofluids over the last ten years (2012–2022). Specifically, some interesting and innovative technologies are highlighted. In the last section, after discussing the challenges in this field, we offer some future directions, such as application of advanced nanomaterials, novel power sources, simultaneous detection of multiple markers and a closed-loop system.

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Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes

Cited by 48 publications

References 36 publications

Surface Modification of Liquid Metal with p-Aniline Derivatives toward Bioapplications: Biosensing as an Example

Surface Modification of Liquid Metal with p-Aniline Derivatives toward Bioapplications: Biosensing as an Example

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

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