Smartphone spectrometer for colorimetric biosensing

Wang, Yi; Liu, Xiaohu; Chen, Peng; Tran, Nhung Thi; Zhang, Jinling; Chia, Wei Sheng; Boujday, Souhir; Liedberg, Bo

doi:10.1039/c5an02508g

Cited by 130 publications

(71 citation statements)

References 43 publications

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“…The micro-spectrometer is one of the most important components in optical sensing that transduce optical responses into electrical signals. Extensive research has been performed to enhance optical resolution and sensing speed, while reducing the physical size [30,31,32]. For biomedical or behavioral animal research, a miniaturized spectrometer is essential for implantation or loading when using an animal model.…”

Section: Methodsmentioning

confidence: 99%

Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain

Kim

Yoon

Choi

et al. 2016

Sensors

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Real-time monitoring of extracellular neurotransmitter concentration offers great benefits for diagnosis and treatment of neurological disorders and diseases. This paper presents the study design and results of a miniaturized and wireless optical neurotransmitter sensor (MWONS) for real-time monitoring of brain dopamine concentration. MWONS is based on fluorescent sensing principles and comprises a microspectrometer unit, a microcontroller for data acquisition, and a Bluetooth wireless network for real-time monitoring. MWONS has a custom-designed application software that controls the operation parameters for excitation light sources, data acquisition, and signal processing. MWONS successfully demonstrated a measurement capability with a limit of detection down to a 100 nanomole dopamine concentration, and high selectivity to ascorbic acid (90:1) and uric acid (36:1).

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Section: Methodsmentioning

confidence: 99%

Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain

Kim

Yoon

Choi

et al. 2016

Sensors

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“…etc.) [117], which is of extreme relevance for epidemiological data gathered in isolate populations of remote areas in developing countries [118,119]. Tests for the detection of heavy metals, malaria, tuberculosis and for the quantification of vitamins (such as B 12 and D) and glucose have been reported by taking advantage of approaches relying on smartphones [61,117,119,120,121,122,123].…”

Section: General Overview Of Applicationsmentioning

confidence: 99%

Gold Nanoparticles for Diagnostics: Advances towards Points of Care

et al. 2016

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The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted developments in the exploration of biomolecular interactions with AuNP-containing systems, in particular for biomedical applications in diagnostics. These systems show great promise in improving sensitivity, ease of operation and portability. Despite this endeavor, most platforms have yet to reach maturity and make their way into clinics or points of care (POC). Here, we present an overview of emerging and available molecular diagnostics using AuNPs for biomedical sensing that are currently being translated to the clinical setting.

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“…As an example, mobile-phone based colorimetric readers for enzyme-linked immunosorbent assays (ELISA) have recently been developed, requiring the use of mechanical platform and illumination set-up [12] [13]. Moreover, the feasibility of a colorimetric biosensor based on a smartphone spectrometer with an integrated grating was demonstrated [14]. The need of external apparatus may limit the use of the mobile system (first category).…”

Section: Introductionmentioning

confidence: 99%

Self-Referencing Method for Relative Color Intensity Analysis Using Mobile-Phone

Souza¹,

Oliveira²,

Oliveira³

et al. 2018

OPJ

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Mobile-phones have been widely explored on colorimetric evaluations. However, their use with different built-in image systems and acquisition configuration, in an environment with non-controlled illumination, limits the establishment of an accurate color analysis. To overcome this restriction, the determination of the absolute color of an object can be overlooked and a relative color value determined. In this work, we establish a new approach for spectroscopic evaluation based on cell-phone imaging, with no previous calibration, determining relative color values. The standalone relative color intensity method is evaluated under the use of four distinct mobile-phones and different illumination conditions. The capability to distinguish different color shades exploring the proposed self-referenced relative color intensity technique is appraised. Moreover, the potential use of the method is demonstrated by evaluating the chemical-adsorption process of Cysteamine molecules on gold nanoparticle surfaces. The proposed self-referenced technique can improve and expand the use of mobile-phones in spectroscopic applications.

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Smartphone spectrometer for colorimetric biosensing

Cited by 130 publications

References 43 publications

Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain

Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain

Gold Nanoparticles for Diagnostics: Advances towards Points of Care

Self-Referencing Method for Relative Color Intensity Analysis Using Mobile-Phone

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