“…To be successful, clinical trials need to be decentralized, so they can effectively enroll representative populations in real-world settings and collect validated outcomes in novel ways that require minimal effort for subjects. 9 What is needed is a radical redesign of the health care delivery system that leverages digital phenotyping with ubiquitous sensors, privacy-preserving edge computing, and connectivity to create equity-first, communitybased, continuous patient engagement strategies that enable patients to overcome all the barriers to achieving better health outcomes. We previously identified a lack of clarity around shared accountability for reducing risk (eg, patients, providers, health systems) and what interventions are practical, cost-effective, and scalable and proposed a new conceptual model for social and behavioral interventions for stroke prevention.…”