Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer

Fan, Xin; Wan, Xiang; Yang, Zu Li; Fu, Xin; Huang, Yan; Chen, Dian Ke; Song, Shun Xin; Liu, Quentin; Xiao, Huan; Wang, Lei; Wang, Jian Ping

doi:10.1016/j.humpath.2012.03.029

Cited by 70 publications

(52 citation statements)

References 31 publications

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“…Metastases to lymph nodes is the main cause for the morbidity 13 . Current practices for colon cancer treatments encompass combination therapies including fluoropyrimidines, irinotecan or oxaliplatin with side effects depending on the application regimen.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2014

IJPSR

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ABSTRACT:The field of cancer research has been emerged in recent years for the development of specific drugs to cancer treatment. New agents with the ability to provide efficient treatment by reducing side effects has led to new opportunities for improving agents for cytotoxic therapies. While there are several drugs for colon cancer treatment, researchers are trying to evaluate new agents or combinations of existing ones which can be used efficiently. Schiff bases with a wide range of variety and biological properties including anticancer activity might be used for colon cancer treatment. In the current study, a novel schiff base derivative synthesized by our group was tested in vivo for colon cancer. In a model of azoxymethane (AOM) induced colorectal cancer, chemopreventive properties of schiff base was also analyzed in rats. While AOM induced de novo crypt formation, adenocarcinoma and dysplasia development, schiff base application reduced the number of aberrant crypt foci (ACF), dysplasia or adenocarcinoma. Analysis of the intestinal mucosa showed that peritoneal administration of SB complex not only decreased the protein expression of COX-2, Bcl-2 and NF-κB but also enhanced the Bax expression suggesting the apoptotic and anti-proliferative effects for this compound. Our findings showed that SB complex might be used for the colorectal cancer treatment. Further studies are highly warranted to obtain additional insights and identify mode of action for the schiff base.

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Section: Discussionmentioning

confidence: 99%

Untitled

2014

IJPSR

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“…Twist enhances EMT, Snail promotes lymph node metastasis in CRC [134]. Both are upregulated by hypoxia in a HIF dependent manner [135][136][137].…”

Section: Colorectal Cancermentioning

confidence: 99%

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

D'Ignazio¹,

Batie²,

Rocha³

2017

Preprint

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Cancer is often characterised by the presence of hypoxia and inflammation.Paramount to the mechanisms controlling cellular responses under such stress stimuli, are the transcription factor families of Hypoxia Inducible Factor (HIF) and NuclearFactor of kappa-light-chain-enhancer of activated B cells (NF-κB). Although, a detailed understating of how these transcription factors respond to their cognate stimulus is well established, it is now appreciated that HIF and NF-κB undergo extensive crosstalk, in particular in pathological situations such as cancer. Here, we focus on the current knowledge on how HIF is activated by inflammation and how NF-κB is modulated by hypoxia. We summarise the evidence for the possible mechanism behind this activation and how HIF and NF-κB function impacts cancer, focusing on colorectal, breast and lung cancer. We discuss possible new points of therapeutic intervention aiming to harness the current understanding of the HIF-NF-κB crosstalk.

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“…Of these, four that measured protein (23,(30)(31)(32) and one that measured RNA (33) failed to provide information on the number of tumors considered marker positive. Among the other 15 studies, a wide range of definitions of marker-positive status were used (17,19,20,25,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). Percentage of subjects with positive expression varied but mainly fell between 30% and 70%.…”

Section: E-cadherinmentioning

confidence: 99%

“…Four studies looked at survival by E-cadherin status, with three finding poorer survival associated with reduced E-cadherin expression (34,37,42) and one finding no difference by E-cadherin status (39). Three studies looked at effect estimates, with two finding no effect of E-cadherin levels on outcomes (20,36) and one finding that E-cadherin levels do affect patient outcomes (42).…”

Section: E-cadherinmentioning

confidence: 99%

“…Three found 40% to 55% of subjects with positive expression (19,20,36) and two in the range of 75% to 80% (39,49), though the studies used a variety of definitions of Snailpositive status. Of the three studies that looked at survival, two found worse survival in Snail-positive subjects than Snail-negative subjects (19,49), and the other study found no difference by Snail expression status (39).…”

Section: Snailmentioning

confidence: 99%

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The Potential for Markers of Epithelial–Mesenchymal Transition to Improve Colorectal Cancer Outcomes: A Systematic Review

Busch¹,

McGraw

Sandler³

2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epithelial-mesenchymal transition (EMT) is thought to be an important mechanism of cancer cell metastasis. Clinical measurement of EMT markers in primary tumors could improve risk stratification and treatment decisions by identifying patients who potentially have metastatic disease. To evaluate the potential of EMT markers that could be used for risk stratification for patients with colorectal cancer, we conducted a systematic review of studies (N ¼ 30) that measured at least one of a selection of EMT markers in primary tumors and patient outcomes. Fifteen of 30 studies (50%) reported at least one statistically significant result supporting a role for one of the selected EMT markers in identifying patients at risk for worse outcomes. Importantly, however, we identified design inconsistencies that limited inferences and prevented meta-analysis of data. We offer a number of recommendations to make future studies more informative and standardized, including consistent sampling of different parts of the primary tumor, larger sample sizes, and measurement of both protein and RNA expression of a given EMT marker in the same tumors. Strengthening the literature per our recommendations could facilitate translating EMT markers to clinical use. Cancer Epidemiol Biomarkers Prev; 23(7); 1164-75. Ó2014 AACR.

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Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer

Cited by 70 publications

References 31 publications

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Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

The Potential for Markers of Epithelial–Mesenchymal Transition to Improve Colorectal Cancer Outcomes: A Systematic Review

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