Snakebite envenomation in the Brazilian Amazon: a descriptive study

Magalhães, Samara Freire Valente; Peixoto, Henry Maia; Moura, Noely Fabiana Oliveira de; Monteiro, Wuelton Marcelo; Oliveira, Maria Regina Fernandes de

doi:10.1093/trstmh/try121

Cited by 54 publications

(48 citation statements)

References 34 publications

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“…Most of the registered accidents were attributed to Bothrops (76.36%), which corroborates information in the literature which states that this type of envenomation is the most frequent in the Amazon 6,18,19 . As expected, envenomation by Micrurus and Lachesis were uncommon (less than 2% each), and corroborates findings by other authors for the same region 5,6,19,20 . There was no record of an envenomation involving Crotalus in this study.…”

Section: Discussionsupporting

confidence: 89%

“…The fact that the higher frequency of victims were male and bitten on the lower limbs corresponded to the epidemiological profile observed for the Brazilian Amazon 5,6,8,19 , as well as for the other regions of Brazil 28 .…”

Section: Discussionsupporting

confidence: 69%

“…In regard to the locations of the accidents, it is noted that, in general, the rural areas showed slightly more than half of the cases (53.94%), and when analyzing only the municipality of Rio Branco, there was a greater predominance in the urban area (60.17%), contrary to what was observed in other studies, in which there is a greater predominance of snakebites in rural areas (more than 85% of the cases) 5,6,11,19 . This urbanization of snakebites was also observed for Belém do Pará in the eastern Amazon 29 , where 66% of cases were recorded in the urban area.…”

Section: Discussioncontrasting

confidence: 55%

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Snakebites in Rio Branco and surrounding region, Acre, Western Brazilian Amazon

Oliveira

Moreira

Sachett³

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Snakebites are considered a neglected tropical disease in many countries in Latin America, including Brazil. As few studies have assessed snakebites in the Amazon region and especially in the state of Acre, epidemiological studies are of great importance. The present study aimed to describe the epidemiological characteristics of snakebites in the Rio Branco region, observing their characteristics in rural and urban areas and their correlation with rainfall and river outflow. Methods: This retrospective, descriptive study analyzed epidemiological information obtained from snakebite notifications registered on the Information System for Notifiable Diseases that occurred from March, 2018 to February, 2019. The cases of snakebite were correlated with rainfall and flow. Results: A total of 165 cases of snakebite were registered in the period. Most cases were caused by Bothrops and affected mainly individuals of the male sex who were between 21 and 30 years old. Most of the snakebites occurred in Rio Branco (71.52%; 29 cases per 100,000 inhabitants). Of these, 60.2% occurred in the urban area and 39.8% in the rural area and the majority occurred during the rainy season. Conclusions: Although studies have shown that a majority of cases occur in rural areas, in this study, urbanization of snakebites was observed. The Bothrops genus was responsible for the highest number of snakebites and, during the rainy season, bites occurred more frequently. Educational prevention campaigns, population advice, and first aid in case of snakebites for the population are thus suggested.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 69%

Section: Discussioncontrasting

confidence: 55%

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Snakebites in Rio Branco and surrounding region, Acre, Western Brazilian Amazon

Oliveira

Moreira

Sachett³

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…Envenoming by Bothrops causes local tissue damage (haemorrhage, necrosis, blistering, and oedema) and systemic alterations associated with bleeding, coagulopathy, haemodynamic alterations, and nephrotoxicity. The clinical effects caused by envenomation are closely related to the venoms’ composition and biochemistry …”

Section: Introductionmentioning

confidence: 99%

“…The clinical effects caused by envenomation are closely related to the venoms' composition and biochemistry. [1][2][3] The entry of snake venom components into tissues affects cells in various ways. Direct cytotoxicity, leading to necrosis, represents one outcome of envenomation.…”

Section: Introductionmentioning

confidence: 99%

Lectin isolated from Bothrops jararacussu venom induces IL-10 release by TCD4+ cells and TNF-α release by monocytes and natural killer cells

Pires

Kayano

Castro

et al. 2019

Journal of Leukocyte Biology

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BjcuL is a C‐type lectin isolated from Bothrops jararacussu snake venom with specificity for binding β‐d‐galactose units. BjcuL is not toxic to human peripheral blood mononuclear cells (PBMCs), but it inhibits PBMC proliferation and stimulates these cells to produce superoxide anions and hydrogen peroxide primarily via lymphocyte stimulation; it does not stimulate the production of nitric oxide and PGE2. The purpose of this study was to investigate the effect of BjcuL on PBMC activation with a focus on cytokine release modulating PBMC proliferation. The results showed for the first time that BjcuL coupled to FITC interacted with monocytes, B cells, natural killer (NK) cells, and with subpopulations of T cells. These cell‐cell interactions can lead to cell activation and inflammatory cytokines release, such as IL‐6 and TNF‐α, as well as the anti‐inflammatory cytokine IL‐10. In addition, TNF‐α release was attributed to NK cells and monocytes, whereas IL‐10 was attributed to TCD4+ and Treg cells when stimulated by BjcuL. The temporal cytokines profile produced by cells when stimulated with this lectin allows us to assert that BjcuL has immunomodulatory activity in this context.

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Coral Snake Envenomations in Central and South America

Greene¹

2020

Curr Trop Med Rep

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Snakebite envenomation in the Brazilian Amazon: a descriptive study

Cited by 54 publications

References 34 publications

Snakebites in Rio Branco and surrounding region, Acre, Western Brazilian Amazon

Snakebites in Rio Branco and surrounding region, Acre, Western Brazilian Amazon

Lectin isolated from Bothrops jararacussu venom induces IL-10 release by TCD4+ cells and TNF-α release by monocytes and natural killer cells

Coral Snake Envenomations in Central and South America

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