Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing

Yan, Jinxin; Wang, Yu; Zhang, Xuan; Zhao, Xiaoliang; Ma, Jianzhong; Pu, Ximing; Wang, Yonggang; Ran, Fen; Wang, Yanling; Leng, Feifan; Zhang, Weijie

doi:10.1016/j.ijbiomac.2018.10.008

Cited by 43 publications

(23 citation statements)

References 29 publications

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“…In this sense, hydrogels are postulated as one of the most suitable classes of ink materials for 3D printing, acquiring an important role in the development of biomedical devices [ 61 ]. They have the ability to be fabricated in customized shapes and offer many advantages for cell culture [ 62 ] and pharmaceutical formulations [ 34 , 35 ]. Other natural products such as gelatin or sodium hyaluronate are employed, due to their ability to adjust the viscosity of the slurry at body temperature by PAM 3D printing, which is very important in the case of the use of cells in tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

“…As well as in FDM, the drug is incorporated before extrusion [ 30 ]. In the last three years, the PAM technique has been employed in 8 studies with natural products to obtain drug delivery systems [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. These studies have been classified according to the nature of the natural product in 3D printed systems employing polysaccharides, proteins and lipids.…”

Section: Nozzle-based Deposition Systemsmentioning

confidence: 99%

“…Other polysaccharides less commonly employed in the manufacture of drug delivery systems, such as Snakegourd root and Astragalus root , derived from the Chinese traditional medicine, have also been employed by the PAM 3D printing technique. These products show properties such as anti-tumor, immunoregulation and hypoglycemic activity, and were employed by Yan et al [ 35 ], crosslinked with carboxymethyl chitosan (CMC) to prepare hydrogels with different shapes (square, circle rectangle (see Figure 3 )) intended to treat diabetic ulcers.…”

Section: Nozzle-based Deposition Systemsmentioning

confidence: 99%

“… Three different shapes of polysaccharide hydrogel tablets for 3D printing (from Yang et al [ 35 ], with permission). …”

Section: Figurementioning

confidence: 99%

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3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

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In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.

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Section: Discussionmentioning

confidence: 99%

Section: Nozzle-based Deposition Systemsmentioning

confidence: 99%

Section: Nozzle-based Deposition Systemsmentioning

confidence: 99%

“… Three different shapes of polysaccharide hydrogel tablets for 3D printing (from Yang et al [ 35 ], with permission). …”

Section: Figurementioning

confidence: 99%

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3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

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“…The new layer is bonded with the old layer already formed, and the layers are continuously sintered and formed (Beaulieu et al, 2019; Grillo et al, 2018). DIW (Bahcecioglu, Hasirci, Bilgen, & Hasirci, 2019; Wu & Hong, 2019; Xu et al, 2019; Yan et al, 2019) uses materials with rheological properties (such as conductive adhesives, elastomers, and hydrogels) as “inks.” The “inks” flow out of the nozzle according to the layering of the 3D computer‐aided design models. It can be deposited into a specific shape as the nozzle moves.…”

Section: Overview Of 3d Printing Technologiesmentioning

confidence: 99%

Three‐dimensional printing: The potential technology widely used in medical fields

Fan

Zhu

2020

J Biomedical Materials Res

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Three‐dimensional (3D) printing technology is one of the hottest research fields nowadays, which has influenced the treatment methods in the medical industry. In order to explore the progress of 3D printing technology in medical applications, the authors conducted English retrieval with the keywords “three‐dimensionalprinting,” “bioprinting,” and “3D printing” in PubMed, and extracted information related to this exploration. This review firstly introduces the 3D printing materials, types of technology, and printing procedures in medical fields, then elaborates the current applications of 3D printing in medical devices, in vitro anatomical models, organ printing, implants, tissue engineering scaffolds, and the leap from 3D medical printing to four‐dimensional (4D) medical printing, finally put forward the shortage of the medical 3D/4D printing and possible solutions of them.

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Engineering multifunctional adhesive hydrogel patches for biomedical applications

Chakraborty,

Alexander,

Luo

et al. 2023

Interdisciplinary Medicine

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Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged as an efficient bioactive multifunctional alternative. Hydrogels are three‐dimensional, water‐swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties of hydrogels can be modified easily, allowing them to be suitable for various biomedical applications. Moreover, adhesive properties can be imparted to hydrogels through physicochemical manipulations, making them ideal candidates for supplementing or replacing traditional sticking plaster. As a result, sticky hydrogel patches are widely used for transdermal drug delivery and have even found commercial purposes. Beyond transdermal delivery, such hydrogel patches have also found applications in cardiac therapy, cancer research, and biosensing, among other applications. In this mini‐review, we critically discuss the challenges of fabricating multifunctional adhesive hydrogel patches. Furthermore, we introduce some of the chemical strategies involved with fabricating the patches. We also review their emerging biomedical applications. Finally, we explore their potential future in the flourishing field of tissue engineering and drug delivery.

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Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing

Cited by 43 publications

References 29 publications

3D Printed Drug Delivery Systems Based on Natural Products

3D Printed Drug Delivery Systems Based on Natural Products

Three‐dimensional printing: The potential technology widely used in medical fields

Engineering multifunctional adhesive hydrogel patches for biomedical applications

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