SNAREs: Cogs and Coordinators in Signaling and Development

Bassham, Diane C.; Blatt, Michael R.

doi:10.1104/pp.108.121129

Cited by 96 publications

(110 citation statements)

References 142 publications

(175 reference statements)

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“…The Arabidopsis Qa-SNAREs SYP121 (=SYR1/PEN1) and SYP122 exhibit high sequence homology and overlapping functions, and both are present at the plasma membrane of cells throughout the plant (Lipka et al, 2007;Bassham and Blatt, 2008). Along with the Qa-SNARE SYP132, which is constitutively expressed and present at low levels (Enami et al, 2009), these proteins mediate secretory vesicle traffic, contributing to cellular homeostasis, expansion, and growth (Blatt, 2000;Shope et al, 2003;Campanoni and Blatt, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The Qa-SNAREs of the plasma membrane are a case in point. In Arabidopsis thaliana, two of these SNAREs, SYP121 (=SYR1/PEN1) and SYP122, show a high degree of structural homology and overlap in function (Assaad et al, 2004;Tyrrell et al, 2007;Bassham and Blatt, 2008;Rehman et al, 2008). Single mutations of these Qa-SNAREs have little effect on plant growth under many conditions, and reduced growth is normally evident only in the syp121/syp122 double mutant (Assaad et al, 2004;Zhang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Plants display the widest spatiotemporal and developmental distribution of SNAREs among eukaryotes (Sanderfoot et al, 2000;Pratelli et al, 2004), reflecting the need for specialized functions throughout the life cycle of the plant (Bassham and Blatt, 2008;Grefen and Blatt, 2008). The Qa-SNAREs of the plasma membrane are a case in point.…”

Section: Introductionmentioning

confidence: 99%

“…SNAREs drive the fusion of vesicle and target membranes and enable the transfer of soluble and membrane-associated cargos in a highly regulated manner (Pratelli et al, 2004;Jahn and Scheller, 2006;Lipka et al, 2007;Bassham and Blatt, 2008). In plant cells, SNARE-mediated vesicle traffic delivers wall materials and membrane to the cell surface, making essential contributions to homeostasis, cell expansion, and growth (Blatt, 2000;Shope et al, 2003;Campanoni and Blatt, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Binding of SEC11 Indicates Its Role in SNARE Recycling after Vesicle Fusion and Identifies Two Pathways for Vesicular Traffic to the Plasma Membrane

et al. 2015

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SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins drive vesicle fusion in all eukaryotes and contribute to homeostasis, pathogen defense, cell expansion, and growth in plants. Two homologous SNAREs, SYP121 (=SYR1/PEN1) and SYP122, dominate secretory traffic to the Arabidopsis thaliana plasma membrane. Although these proteins overlap functionally, differences between SYP121 and SYP122 have surfaced, suggesting that they mark two discrete pathways for vesicular traffic. The SNAREs share primary cognate partners, which has made separating their respective control mechanisms difficult. Here, we show that the regulatory protein SEC11 (=KEULE) binds selectively with SYP121 to affect secretory traffic mediated by this SNARE. SEC11 rescued traffic block by dominant-negative (inhibitory) fragments of both SNAREs, but only in plants expressing the native SYP121. Traffic and its rescue were sensitive to mutations affecting SEC11 interaction with the N terminus of SYP121. Furthermore, the domain of SEC11 that bound the SYP121 N terminus was itself able to block secretory traffic in the wild type and syp122 but not in syp121 mutant Arabidopsis. Thus, SEC11 binds and selectively regulates secretory traffic mediated by SYP121 and is important for recycling of the SNARE and its cognate partners.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Binding of SEC11 Indicates Its Role in SNARE Recycling after Vesicle Fusion and Identifies Two Pathways for Vesicular Traffic to the Plasma Membrane

et al. 2015

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“…The involvement of a large number of regulatory molecules is discussed in the Updates on the small regulatory RAB and ARF GTPases by Nielsen et al (2008), on SNAREs by Bassham and Blatt (2008), and on Rho GTPases by Yalovsky et al (2008). Studies in these areas have advanced so much in the last few years that these Updates have gone far beyond a catalog of molecules and their potential functions and include vigorous discussions on the cellular, physiological, and developmental events that these molecules regulate, how they themselves are regulated, and how these regulatory pathways may integrate in the control of vesicular transport.…”

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confidence: 99%