SNF472: a novel therapeutic agent for vascular calcification and calciphylaxis

Can ethylene diamine tetra‐acetic acid improve calcium fracture when combined with intravascular lithotripsy?

“…Recent clinical studies have confirmed its efficacy and safety to target coronary artery calcification (phase 2 clinical trial) and calciphylaxis (phase 3 clinical trials) in end-stage renal disease patient on hemodialysis. 4 The concept of "DCB-only" therapy, in conjunction with a high-pressure balloon, also warrants exploration as a potentially less expensive complementary approach in treating calcified lesions. EDTA or SNF472 could be applied to a calcified lesion via a perfusion balloon, to initiate dissolving the hydroxyapatite.…”