SNP dependent modulation of circulating miRNAs from the miR25/93/106 cluster in patients undergoing weight loss

Müller, Stephanie; Wallner, Stefan; Schmitz, Gerd; Loew, Thomas; Stempfl, Thomas; Möhle, Christoph; Strack, Christina; Sag, Sabine; Baessler, Andrea; Fischer, Marcus

doi:10.1016/j.gene.2020.144787

Cited by 4 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The studies were analyzed for differences between their study populations. The majority of the studies included both sexes [12,15,16,19,20,22,[24][25][26][30][31][32][35][36][37][38], although six articles only investigated the effect of weight loss in women [17,21,23,27,29,34] and four investigated the effects in male subject groups [7,18,33,39]. Only two articles specified the ethnicity of the included participants: African-American women [34] and Caucasian males [7].…”

Section: Patient Populations In the Included Studiesmentioning

confidence: 99%

“…Any other definition of ethnicity would be made by the authors based on the last names of any author or co-author as well as the research location. Moreover, there are differences in their intervention approaches; ten studies investigated the effects of dietary changes alone [12,16,21,22,27,29,33,36,39], nine articles investigated the effect of surgeryinduced weight loss [15,19,20,[30][31][32]34,35,38], and one article investigated the effect of the combination of surgery and diet [7]. Furthermore, two studies investigated the effects of exercise [17,26], whilst four combined the effects of diet and exercise [18,23,25,28], and lastly, one article investigated the effects of a fasting regimen [37].…”

Section: Patient Populations In the Included Studiesmentioning

confidence: 99%

“…The majority of studies investigated miRNAs in plasma [7,17,20,21,[23][24][25][26][27][28]30,[34][35][36]; the rest were distributed as (41%) investigating serum [12,15,16,18,19,29,31,32,[37][38][39] or whole blood (7%) [22,33]. Moreover, 18.5% of the studies used a single-step centrifugation process for plasma or serum separation [16,22,28,35,37], while 15% used a two-step centrifugation [7,17,24,31].…”

Section: Evaluation Of Pre-analytical Factorsmentioning

confidence: 99%

“…Furthermore, 7.5% used immunoprecipitation [19,39], while 59% of the studies did not provide information about the separation process [12,15,18,20,21,23,[25][26][27]29,30,[32][33][34][35]38] (Figure 3, Supplementary Materials File S3). For RNA extraction, the studies used different commercially branded reagents s as Trizol (11%) [12,22,27] or kits such as as miRVANA (18.5%) [7,30,32,34,35] or miRNe (41%) [15,16,[19][20][21]23,24,31,36,38,39]. Twenty-two percent used other For RNA extraction, the studies used different commercially branded reagents such as Trizol (11%) [12,22,27] or kits such as as miRVANA (18.5%) [7,30,32,34,35] or miRNeasy (41%)…”

Section: Evaluation Of Pre-analytical Factorsmentioning

confidence: 99%

See 3 more Smart Citations

Extracellular microRNAs in Relation to Weight Loss—A Systematic Review and Meta-Analysis

Veie,

Nielsen,

Frisk

et al. 2023

ncRNA

View full text Add to dashboard Cite

Obesity is an important risk factor for cardiovascular disease and type 2 diabetes mellitus. Even a modest weight loss of 5–15% improves metabolic health, but circulating markers to indicate weight loss efficiency are lacking. MicroRNAs, small non-coding post-transcriptional regulators of gene expression, are secreted from tissues into the circulation and may be potential biomarkers for metabolic health. However, it is not known which specific microRNA species are reproducibly changed in levels by weight loss. In this study, we performed a systematic review and meta-analysis to investigate the microRNAs associated with weight loss by comparing baseline to follow-up levels following intervention-driven weight loss. This systematic review was performed according to the PRISMA guidelines with searches in PubMed and SCOPUS. The primary search resulted in a total of 697 articles, which were screened according to the prior established inclusion and exclusion criteria. Following the screening of articles, the review was based on the inclusion of 27 full-text articles, which were evaluated for quality and the risk of bias. We performed systematic data extraction, whereafter the relative values for miRNAs were calculated. A meta-analysis was performed for the miRNA species investigated in three or more studies: miR-26a, miR-126, and miR-223 were overall significantly increased following weight loss, while miR-142 was significantly decreased after weight loss. miR-221, miR-140, miR-122, and miR-146 were not significantly changed by intervention-driven weight loss. These results indicate that few miRNAs are significantly changed during weight loss.

show abstract

Section: Patient Populations In the Included Studiesmentioning

confidence: 99%

Section: Patient Populations In the Included Studiesmentioning

confidence: 99%

Section: Evaluation Of Pre-analytical Factorsmentioning

confidence: 99%

Section: Evaluation Of Pre-analytical Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Extracellular microRNAs in Relation to Weight Loss—A Systematic Review and Meta-Analysis

Veie,

Nielsen,

Frisk

et al. 2023

ncRNA

View full text Add to dashboard Cite

show abstract

“…However, an integrative model using microbiota and genetic information was proposed to prescribe two hypocaloric diets with different micronutrient distribution for a successful weight loss in individuals with excess of body weight [ 30 ]. Moreover, diet induced weight loss led to polymorphism-dependent modulation of miRNAs from the miR 25/93/106 gene cluster in humans [ 31 ].…”

Section: Genomics In Combination Epigenomics Metagenomics Transcripto...mentioning

confidence: 99%

Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease

2022

View full text Add to dashboard Cite

The combination of multiple omics approaches has emerged as an innovative holistic scope to provide a more comprehensive view of the molecular and physiological events underlying human diseases (including obesity, dyslipidemias, fatty liver, insulin resistance, and inflammation), as well as for elucidating unique and specific metabolic phenotypes. These omics technologies include genomics (polymorphisms and other structural genetic variants), epigenomics (DNA methylation, histone modifications, long non-coding RNA, telomere length), metagenomics (gut microbiota composition, enterotypes), transcriptomics (RNA expression patterns), proteomics (protein quantities), and metabolomics (metabolite profiles), as well as interactions with dietary/nutritional factors. Although more evidence is still necessary, it is expected that the incorporation of integrative omics could be useful not only for risk prediction and early diagnosis but also for guiding tailored dietary treatments and prognosis schemes. Some challenges include ethical and regulatory issues, the lack of robust and reproducible results due to methodological aspects, the high cost of omics methodologies, and high-dimensional data analyses and interpretation. In this review, we provide examples of system biology studies using multi-omics methodologies to unravel novel insights into the mechanisms and pathways connecting the genotype to clinically relevant traits and therapy outcomes for precision nutrition applications in health and disease.

show abstract

A Higher-Protein, Energy Restriction Diet Containing 4 Servings of Fresh, Lean Beef per Day Does Not Negatively Influence Circulating miRNAs Associated with Cardiometabolic Disease Risk in Women with Overweight

Piacquadio,

Gwin,

Leidy

2024

Current Developments in Nutrition

View full text Add to dashboard Cite

SNP dependent modulation of circulating miRNAs from the miR25/93/106 cluster in patients undergoing weight loss

Cited by 4 publications

References 45 publications

Extracellular microRNAs in Relation to Weight Loss—A Systematic Review and Meta-Analysis

Extracellular microRNAs in Relation to Weight Loss—A Systematic Review and Meta-Analysis

Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease

A Higher-Protein, Energy Restriction Diet Containing 4 Servings of Fresh, Lean Beef per Day Does Not Negatively Influence Circulating miRNAs Associated with Cardiometabolic Disease Risk in Women with Overweight

Contact Info

Product

Resources

About